2-hydroxynaphthaleneacetaldehyde | 848029-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-hydroxynaphthaleneacetaldehyde
• 英文别名: 2-(2-Hydroxynaphthalen-1-yl)acetaldehyde
• CAS: 848029-63-0
• 化学式: C₁₂H₁₀O₂
• 分子量: 186.21
• InChiKey: IOABJCTUNLORSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxynaphthaleneacetaldehyde 在 氢氧化钾 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 甲醇 、 水 、 苯 为溶剂， 反应 17.0h， 生成 (+/-) (7aRS,10aRS)-7a,8,9,10a-tetrahydrofuro[3,2-b]naphtho[1,2-d]furan-9-one
  参考文献：
  名称：

  DDQ induced oxidative cyclisations of 1,2-dihydronaptho[2,1-b]furans

  摘要：

  The DDQ mediated oxidative cyclisation reactions of a series of dihydronaptho[2,1-b]furans were examined. In the presence of an acid catalyst, the reaction yielded polycyclic ethers and lactones in good to excellent yields. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.12.010
• 作为产物：
  描述：

  2,4a-dihydronaphtho[2,1-c][1,2]dioxine 在 三乙烯二胺 作用下， 以95%的产率得到2-hydroxynaphthaleneacetaldehyde
  参考文献：
  名称：

  DDQ induced oxidative cyclisations of 1,2-dihydronaptho[2,1-b]furans

  摘要：

  The DDQ mediated oxidative cyclisation reactions of a series of dihydronaptho[2,1-b]furans were examined. In the presence of an acid catalyst, the reaction yielded polycyclic ethers and lactones in good to excellent yields. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.12.010

文献信息

• [EN] ALANINE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE<br/>[FR] MODULATEURS DE PROTÉOLYSE À BASE D'ALANINE ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：ARVINAS INC

  公开号：WO2017011590A1

  公开（公告）日：2017-01-19

  The description relates to inhibitors of Apoptosis Proteins (TAPs) binding compounds, including Afunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the IAP E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.

  描述涉及抑制凋亡蛋白（TAPs）结合化合物，包括包含相同的A功能化合物，这些化合物作为靶向泛素化的调节剂发挥作用，特别是根据本发明的双功能化合物抑制各种多肽和其他蛋白质的化合物。具体而言，描述提供了一端含有结合到IAP E3泛素连接酶的配体，另一端含有结合到靶蛋白的基团的化合物，使得靶蛋白靠近泛素连接酶以促使该蛋白的降解（和抑制）。可以合成化合物，表现出与几乎任何类型的靶向多肽的降解/抑制一致的广泛药理活性。
• [EN] TRPM8 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DES RÉCEPTEURS TRPM8
  申请人：DOMPE SPA

  公开号：WO2012101244A1

  公开（公告）日：2012-08-02

  Compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (hereinafter referred to as TRPM8), having formula (I), wherein R is selected from: - H, Br, CN, NO2, SO2NH2, SO2NHR' and SO2NR'2, where R' is selected from linear or branched C1-C4 alkyl; X is selected from: - F, C1, C1-C3 alkyl, NH2 and OH Y is selected from: - O, CH2, NH and SO2 R1 and R2, independently one from the other, are selected from - H, F and linear or branched C1-C4 alkyl; R3 and R4, independently one from the other, are selected from - H and linear or branched C1-C4 alkyl; Z is selected from: - NR6 and R6R7N+, where R6 and R7 independently one from the other, are selected from: • H and linear or branched C1-C4 alkyl R5 is a residue selected from: - H and linear or branched C1-C4 alkyl Het is a heteroaryl group selected from - a substituted or not substituted pyrrolyl, a substituted or not substituted N- methylpyrrolyl, a substituted or not substituted thiophenyl, a substituted or not substituted furyl and a substituted or not substituted pyridinyl. Said compounds are useful in the prevention and treatment of pathologies depending on TRPM8 activity such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, inflammatory conditions and urological disorders.

  作为Transient Receptor Potential阳离子通道亚家族M成员8（以下简称为TRPM8）的选择性拮抗剂的化合物，具有以下式（I），其中R选自：- H、Br、CN、NO2、SO2NH2、SO2NHR'和SO2NR'2，其中R'选自线性或支链的C1-C4烷基；X选自：- F、C1、C1-C3烷基、NH2和OH；Y选自：- O、CH2、NH和SO2；R1和R2，彼此独立地选自- H、F和线性或支链的C1-C4烷基；R3和R4，彼此独立地选自- H和线性或支链的C1-C4烷基；Z选自：- NR6和R6R7N+，其中R6和R7彼此独立地选自：• H和线性或支链的C1-C4烷基；R5是从- H和线性或支链的C1-C4烷基中选出的残基；Het是从- 取代或未取代的吡咯基、取代或未取代的N-甲基吡咯基、取代或未取代的噻吩基、取代或未取代的呋喃基和取代或未取代的吡啶基中选出的杂环芳基团。所述化合物在预防和治疗依赖于TRPM8活性的病理病变中具有用途，如疼痛、炎症、缺血、神经退行性、中风、精神障碍、炎症性疾病和泌尿系统疾病。
• 一种氧硫杂环戊烷-苯并香豆素化合物及其制备方法和作为荧光探针的用途
  申请人：天水师范学院

  公开号：CN114736195A

  公开（公告）日：2022-07-12

  本发明涉及荧光探针技术领域，公开了一种氧硫杂环戊烷‑苯并香豆素化合物及其制备方法和作为荧光探针的用途。本发明的氧硫杂环戊烷‑苯并香豆素化合物以苯并香豆素为荧光团，该化合物作为荧光探针，具有良好的光学性质、能专一识别HClO，并且响应时间快、pH应用范围广、检出限低，水溶性好。此外，本发明的探针BMH能作为固体探针被应用于对HClO的快速检测，也可用于检测实际水样中的HClO，以获得满意的回收率，且具有良好的生物相容性，可成功应用于精确监测天然HClO以及活RAW 264.7细胞内内源性和外源性HClO水平的变化。
• 2-OXAZOLAMINES AND THEIR USE AS 5-HT2B RECEPTOR ANTAGONISTS
  申请人：Pharmagene Laboratories Ltd

  公开号：EP1474140A1

  公开（公告）日：2004-11-10
• THIOCHROMENE DERIVATIVES AS HIP HYDROXYLASE INHIBITORS
  申请人：Fibrogen, Inc.

  公开号：EP2370422A1

  公开（公告）日：2011-10-05