4-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxaldehyde | 503058-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 香豆素
• 英文名称: 4-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxaldehyde
• 英文别名: 4-methoxy-2,2-dimethyl-3H-1-benzofuran-7-carbaldehyde
• CAS: 503058-06-8
• 化学式: C₁₂H₁₄O₃
• 分子量: 206.241
• InChiKey: WLHHFRFSYMMEDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxaldehyde 在 六甲基磷酰三胺 、 正丁基锂 、 叔十六硫醇 、 盐酸 、 sodium hydroxide 作用下， 以 正己烷 为溶剂， 反应 13.33h， 生成 4-hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxaldehyde
  参考文献：
  名称：

  FUSED BENZENE DERIVATIVE AND USE

  摘要：

  公开号：

  EP1553074B1
• 作为产物：
  描述：

  4-methoxy-2-(methoxymethoxy)-3-(2-methyl-2-propenyl)benzaldehyde 在 盐酸 作用下， 以 水 、 异丙醇 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 4-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxaldehyde
  参考文献：
  名称：

  FUSED BENZENE DERIVATIVE AND USE

  摘要：

  公开号：

  EP1553074B1

文献信息

• Oxygen-containing heterocyclic fused naphthopyrans
  申请人：Vision-Ease Lens, Inc.

  公开号：US20030092918A1

  公开（公告）日：2003-05-15

  Novel naphthopyrans having an oxygen-containing heterocyclic group F annelated on the f, i, j, or k side of the naphthopyran ring. These naphthopyrans may have the formula (I) presented below: 1 These compounds (I) have interesting photochromic properties. Various organic host materials that contain such compounds are described. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations are enabled.

  具有含氧杂环基团F的新型萘并吡喃化合物，该杂环基团F连接在萘并吡喃环的f、i、j或k侧。这些萘并吡喃化合物的化学式如下：1这些化合物(I)具有有趣的光致变色性质。本文还描述了含有这些化合物的各种有机宿主材料。可以制备包含这些新型萘并吡喃化合物或其组合物的眼镜镜片或其他塑料透明材料等物品。
• Transcutaneous immunostimulation
  申请人：Finlay Maurice Raymond Verschoyle

  公开号：US20080171743A1

  公开（公告）日：2008-07-17

  A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in disease mediated by an mTOR kinase and/or one or more PI3K enzyme.

  公式为（I）的化合物或其药学上可接受的盐，其制备过程，包含它们的制药组合物以及它们在治疗中的用途，例如在治疗增生性疾病如癌症和特别是由mTOR激酶和/或一个或多个PI3K酶介导的疾病中的用途。
• MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS
  申请人：AstraZeneca AB

  公开号：EP2057140B1

  公开（公告）日：2012-08-08
• Fused benzene derivative and use
  申请人：Shiraishi Mitsuru

  公开号：US20060106067A1

  公开（公告）日：2006-05-18

  The present invention provides a compound represented by the general formula: [wherein Ring A represents an optionally substituted 5- to 8-membered ring, Ring B represents a further optionally substituted 4- to 10-membered ring, Ring C represents a further optionally substituted benzene ring, X 1 represents carbon atom, X 2 represents a carbon atom, an oxygen atom, etc., W represents a nitrogen atom, etc., Y 11 represents a group represented by the formula CR 2 R 3′ (wherein R 2 represents a hydrogen atom, a cyano group, a nitro group, etc., and R 3′ represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), Y 21 represents a group represented by the formula CR 4 R 5′ (wherein R 4 represents a hydrogen atom, a cyano group, a nitro group, etc., and R 5′ represents a hydrogen atom, a cyano group, a nitro group, etc., respectively), etc., and R 1 represents an electron-withdrawing group, respectively. The formula represents a single bond or a double bond] or a salt thereof, which is useful as an androgen receptor modulator.
• US6608215B2
  申请人：——

  公开号：US6608215B2

  公开（公告）日：2003-08-19