2-[2-Methylindol-4-yl]malononitrile | 458530-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-Methylindol-4-yl]malononitrile
• 英文别名: 2-[2-Methyl-1-(4-methylphenyl)sulfonylindol-4-yl]propanedinitrile
• CAS: 458530-61-5
• 化学式: C₁₉H₁₅N₃O₂S
• 分子量: 349.413
• InChiKey: GBMUFIGGFQQGSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  95
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[2-Methylindol-4-yl]malononitrile 在 氢氧化钾 作用下， 以 乙醇 、 水 为溶剂， 反应 23.0h， 以83.8%的产率得到2-[2-Methylindol-4-yl]malononitrile
  参考文献：
  名称：

  EP1367050

  摘要：

  公开号：

文献信息

• 2-methylindole-4-acetic acid, process for producing the same, and process for producing intermediate therefor
  申请人：——

  公开号：US20040092750A1

  公开（公告）日：2004-05-13

  2-Methylindole-4-acetic acid, which is represented by the formula (I) and is an intermediate for an important indole derivative as medicines; and a process for producing the compound and the synthetic intermediates. The process for producing 2-methylindole-4-acetic acid and synthetic intermediates is described in this invention. As shown in formula (I), 2-methylindole-4-acetic acid is an intermediate of important indole derivative which is useful tools for medicine. 1 According to the process described in this invention, 2-methylindole-4-acetic acid, which is an intermediate of important indole derivative as medicines, can be produced in high yield using inexpensive reagents under mild conditions which are suitable for industrial production.

  2-甲基吲哚-4-乙酸，化学式表示为（I），是一种重要的吲哚衍生物药物中间体；本发明提供了一种制备该化合物和合成中间体的方法。本发明描述了制备2-甲基吲哚-4-乙酸和合成中间体的方法。如化学式（I）所示，2-甲基吲哚-4-乙酸是重要的吲哚衍生物的中间体，是药物研究中有用的工具。根据本发明所述的方法，可以在适宜于工业生产的温和条件下，使用廉价试剂高产地制备2-甲基吲哚-4-乙酸，该化合物是重要的吲哚衍生物药物中间体。
• 2-METHYLINDOLE-4-ACETIC ACID, PROCESS FOR PRODUCING THE SAME, AND PROCESS FOR PRODUCING INTERMEDIATE THEREFOR
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1367050A1

  公开（公告）日：2003-12-03

  2-Methylindole-4-acetic acid, which is represented by the formula (I) and is an intermediate for an important indole derivative as medicines; and a process for producing the compound and the synthetic intermediates. The process for producing 2-methylindole-4-acetic acid and synthetic intermediates is described in this invention. As shown in formula (I), 2-methylindole-4-acetic acid is an intermediate of important indole derivative which is useful tools for medicine. According to the process described in this invention, 2-methylindole-4-acetic acid, which is an intermediate of important indole derivative as medicines, can be produced in high yield using inexpensive reagents under mild conditions which are suitable for industrial production.

  2-甲基吲哚-4-乙酸，由式（I）表示，是一种重要的药物吲哚衍生物的中间体；以及生产该化合物和合成中间体的工艺。 本发明描述了生产 2-甲基吲哚-4-乙酸和合成中间体的工艺。如式（I）所示，2-甲基吲哚-4-乙酸是重要吲哚衍生物的中间体，是有用的医药工具。 根据本发明所述工艺，可在温和的条件下使用廉价试剂高产制得 2-甲基吲哚-4-乙酸，而 2-甲基吲哚-4-乙酸是重要的吲哚衍生物中间体，适合工业化生产。
• EP1367050
  申请人：——

  公开号：——

  公开（公告）日：——