1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2,2-difluoroethyl)pyrimidin-2,4(3H)-one | 561320-48-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2,2-difluoroethyl)pyrimidin-2,4(3H)-one
• 英文别名: 5-(2,2-difluoroethyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 561320-48-7
• 化学式: C₁₁H₁₄F₂N₂O₅
• 分子量: 292.239
• InChiKey: DJCMHRMTKYUCCJ-LKEWCRSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-(3,5-di-O-(p-toluoyl)-2-deoxy-β-D-erythro-pentofuranosyl)-5-(2,2-difluoroethyl)-4-methoxypyrimidin-2-one 在 三甲基氯硅烷 、 sodium iodide 、 sodium hydroxide 作用下， 以 乙腈 、 甲醇 为溶剂， 反应 2.08h， 以87%的产率得到1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-(2,2-difluoroethyl)pyrimidin-2,4(3H)-one
  参考文献：
  名称：

  Synthesis of a Novel Aldehyde: 4-O-Methyl-5-formylmethyl- 2′-deoxyuridine

  摘要：

  The synthesis of the blocked nucleoside 3',5'-di-O-p-toluoyl-4-O-methyl-5-formyl-methyl-2'-deoxyuridine (19) was accomplishied in eleven steps from gamma-butyrolactone. This aldehyde, which should facilitate the synthesis of nucleosides containing F-18, was converted to the corresponding blocked dithianyl nucleoside (21), and also to 5-(2,2-difluoroethyl)-substituted derivatives of 2'-deoxyuridine and 2-deoxycytidine.

  DOI：

  10.1081/ncn-120018624

文献信息

• Synthesis of a Novel Aldehyde: 4-O-Methyl-5-formylmethyl- 2′-deoxyuridine
  作者：Chung-Shan Yu、Franz Oberdorfer

  DOI：10.1081/ncn-120018624

  日期：2003.4

  The synthesis of the blocked nucleoside 3',5'-di-O-p-toluoyl-4-O-methyl-5-formyl-methyl-2'-deoxyuridine (19) was accomplishied in eleven steps from gamma-butyrolactone. This aldehyde, which should facilitate the synthesis of nucleosides containing F-18, was converted to the corresponding blocked dithianyl nucleoside (21), and also to 5-(2,2-difluoroethyl)-substituted derivatives of 2'-deoxyuridine and 2-deoxycytidine.