3-(2-甲氧基萘-1-基)吡啶 | 922511-80-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 3-(2-甲氧基萘-1-基)吡啶
• 英文名称: 3-(2-methoxynaphthalen-1-yl)pyridine
• 英文别名: 3-(2-Methoxynaphthalen-1-yl)pyridine
• CAS: 922511-80-6
• 化学式: C₁₆H₁₃NO
• 分子量: 235.285
• InChiKey: GWWYVHNKSGDDHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-溴-2-甲氧基萘 在 cyclopalladated [1-(p-tolylimino)ethyl]ferrocene catalyst 盐酸 、 magnesium 、 cesium fluoride 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 11.0h， 生成 3-(2-甲氧基萘-1-基)吡啶
  参考文献：
  名称：

  通过铃木交叉偶联合成邻位取代的联芳基的有效催化剂：环钯化的二茂铁基亚胺的三苯基膦加合物

  摘要：

  环钯化的二茂铁基亚胺2的空气和湿气稳定的三苯基膦加合物已成功用于钯催化的Suzuki交叉偶联中，以在空气中合成邻位取代的联芳基。在100°C下在二恶烷中0.05摩尔％的2作为催化剂和3当量的CsF作为碱存在下，在2-甲氧基-1-萘基硼酸与芳基的反应中以中等至高的产率合成邻位取代的联芳基得到卤化物和14个新的邻位取代的联芳基并进行了表征。

  DOI：

  10.1016/j.jorganchem.2006.09.023

文献信息

• Synthesis of a class of binaphthyl monophosphine ligands with a naphthofuran skeleton and their applications in Suzuki–Miyaura coupling reactions
  作者：Zihong Zhou、Hao Liang、Wang Xia、Huixuan Chen、Yaqi Zhang、Xuefeng He、Sifan Yu、Rihui Cao、Liqin Qiu

  DOI：10.1039/c8nj00412a

  日期：——

  L6–Pd₂(dba)₃ showed excellent activity in the Suzuki–Miyaura reaction of sterically hindered and electron-rich aryl halides with aryl boronic acids.

  L6-Pd₂(dba)₃在苯基卤代物与苯基硼酸的Suzuki-Miyaura反应中表现出优异的活性。
• 一类含萘并呋喃结构的联芳基单膦配体及其 制备方法和应用
  申请人：中山大学

  公开号：CN105968137B

  公开（公告）日：2018-04-06

  本发明公开了一类含萘并呋喃结构的联芳基单膦配体及其制备方法和应用，该联芳基单膦配体是具有式（Ⅷ）所示化学结构式的化合物或它的对映体或消旋体。本发明的联芳基单膦配体通过引入呋喃环，与所属联萘形成共轭结构，增加了膦配体包括其对映体或消旋体的空间位阻及其芳香环的电子云密度，提高了配合物的稳定性，并调节配体的空间位阻，配体结构新颖，制备过程经过Sonogashira反应、分子内关环、C‑P偶联反应等，合成方法简单，所得配体应用于Suzuki‑Miyuara反应时具有活性高、选择性好等优点。
• URAT1 INHIBITOR
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：US20170290795A1

  公开（公告）日：2017-10-12

  Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia. (In the Formula (III), R 1a , R 2a , R 6a , and R 7a represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or a cyano group, R 3a and R 8a form a benzene ring or a 5-membered heteroaryl ring containing 1 to 3 heteroatoms, as a ring constituent element, selected from nitrogen atoms, oxygen atoms, and sulfur atoms together with two carbon atoms to which R 3a and R 8a are bonded, R 4a and R 5a form a benzene ring together with two carbon atoms to which R 4a and R 5a are bonded or represent any of the groups represented by R 1a described above, W a represents CR 10a or N, and where, R 10a represents any of the groups represented by R 1a , X a represents an oxygen atom or a sulfur atom, Y a represents an alkylene chain having 1 to 8 carbon atoms, and where, the alkylene chain may be substituted with an alkyl group having 1 to 8 carbon atoms and the alkylene chain may be a linear or branched alkylene chain, the branched alkylene chain may have a 3- to 7-membered ring formed by side chains bonded to carbon atoms which are the same as or different from each other, together with the carbon atoms to which the side chains are bonded and may have a double bond in the middle thereof, and Z a represents CO 2 H.)

  提供的是以下公式（III）所代表的化合物，该化合物的互变异构体或立体异构体，或者是作为痛风或高尿酸血症治疗剂的药用可接受盐或溶剂。（在公式（III）中，R1a、R2a、R6a和R7a代表氢原子、具有1至8个碳原子的烷基、具有1至8个碳原子的烷氧基或氰基，R3a和R8a形成苯环或含有1至3个杂原子（从氮原子、氧原子和硫原子中选择）的5元杂环，作为环构成元素，与R3a和R8a结合的两个碳原子一起，R4a和R5a与R4a和R5a结合的两个碳原子一起形成苯环，或代表上述R1a描述的任何基团，W代表CR10a或N，其中R10a代表上述R1a描述的任何基团，X代表氧原子或硫原子，Y代表具有1至8个碳原子的烷基链，其中烷基链可能被具有1至8个碳原子的烷基取代，且烷基链可能是直链或支链烷基链，支链烷基链可能由连接到相同或不同的碳原子的侧链形成3至7个成员环，与侧链结合的碳原子以及可能在其中间具有双键，并且Z代表CO2H。）
• URAT1 inhibitor
  申请人：Nippon Chemiphar Co., Ltd.

  公开号：US10173990B2

  公开（公告）日：2019-01-08

  Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia. (In the Formula (III), R1a, R2a, R6a, and R7a represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, or a cyano group, R3a and R8a form a benzene ring or a 5-membered heteroaryl ring containing 1 to 3 heteroatoms, as a ring constituent element, selected from nitrogen atoms, oxygen atoms, and sulfur atoms together with two carbon atoms to which R3a and R8a are bonded, R4a and R5a form a benzene ring together with two carbon atoms to which R4a and R5a are bonded or represent any of the groups represented by R1a described above, Wa represents CR10a or N, and where, R10a represents any of the groups represented by R1a, Xa represents an oxygen atom or a sulfur atom, Ya represents an alkylene chain having 1 to 8 carbon atoms, and where, the alkylene chain may be substituted with an alkyl group having 1 to 8 carbon atoms and the alkylene chain may be a linear or branched alkylene chain, the branched alkylene chain may have a 3- to 7-membered ring formed by side chains bonded to carbon atoms which are the same as or different from each other, together with the carbon atoms to which the side chains are bonded and may have a double bond in the middle thereof, and Za represents CO2H).

  本发明提供了由下式（III）代表的化合物、该化合物的同分异构体或立体异构体或其药学上可接受的盐或溶液，用作痛风或高尿酸血症的治疗剂。(在式（III）中，R1a、R2a、R6a 和 R7a 代表氢原子、具有 1 至 8 个碳原子的烷基、具有 1 至 8 个碳原子的烷氧基或氰基，R3a 和 R8a 构成苯环或含有 1 至 3 个杂原子的 5 元杂芳基环，作为环组成元素、选自氮原子、氧原子和硫原子，与 R3a 和 R8a 键合的两个碳原子一起，R4a 和 R5a 与 R4a 和 R5a 键合的两个碳原子一起形成苯环，或代表上述 R1a 所代表的任何基团，Wa 代表 CR10a 或 N，其中、R10a 代表 R1a 所代表的任何基团，Xa 代表氧原子或硫原子，Ya 代表具有 1 至 8 个碳原子的亚烷基链，其中，亚烷基链可以被具有 1 至 8 个碳原子的烷基取代，亚烷基链可以是直链或支链亚烷基链、支链亚烷基链可具有一个 3 至 7 元环，该环由与彼此相同或不同的碳原子键合的侧链以及与侧链键合的碳原子形成，并可在其中间具有一个双键，Za 代表 CO2H）。
• An efficient catalyst for the synthesis of ortho-substituted biaryls by the Suzuki cross-coupling: Triphenylphosphine adduct of cyclopalladated ferrocenylimine
  作者：Hong Li、Yangjie Wu、Weibo Yan

  DOI：10.1016/j.jorganchem.2006.09.023

  日期：2006.12

  The air and moisture stable triphenylphosphine adduct of cyclopalladated ferrocenylimine 2 has been successfully used in palladium-catalyzed Suzuki cross-coupling for the synthesis of ortho-substituted biaryls in air. In the presence of 0.05 mol% of 2 as catalyst and 3 equivalent of CsF as base in dioxane at 100 °C, ortho-substituted biaryls were synthesized with moderate to high yields in the reactions

  环钯化的二茂铁基亚胺2的空气和湿气稳定的三苯基膦加合物已成功用于钯催化的Suzuki交叉偶联中，以在空气中合成邻位取代的联芳基。在100°C下在二恶烷中0.05摩尔％的2作为催化剂和3当量的CsF作为碱存在下，在2-甲氧基-1-萘基硼酸与芳基的反应中以中等至高的产率合成邻位取代的联芳基得到卤化物和14个新的邻位取代的联芳基并进行了表征。