2H-1-benzopyran-6-ol | 96549-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2H-1-benzopyran-6-ol
• 英文别名: 6-hydroxybenzo(1,2-b)pyran；2H-chromen-6-ol；6-hydroxybenzopyran；chromene-6-ol
• CAS: 96549-65-4
• 化学式: C₉H₈O₂
• mdl: MFCD18450935
• 分子量: 148.161
• InChiKey: NAHHIXKSGGSPOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2H-1-benzopyran-6-ol 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 8.0h， 生成 benzo(1,2-b;4,3-b)dipyran
  参考文献：
  名称：

  Venugopalan, Bindumadhavan; Balasubramanian,Kalpattu Kuppuswamy, Heterocycles, 1985, vol. 23, # 1, p. 81 - 92

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(prop-2-yn-1-yloxy)phenol 在 Ph₃PAuNTf₂ 作用下， 以 二氯甲烷 为溶剂， 反应 0.67h， 以73%的产率得到2H-1-benzopyran-6-ol
  参考文献：
  名称：

  [EN] NOVEL USE OF SUBSTITUTED 2H-CHROMENS AND THEIR DERIVATIVES
  [FR] NOUVELLE UTILISATION DES 2H-CHROMÈNES SUBSTITUÉS ET DE LEURS DÉRIVÉS

  摘要：

  本发明涉及使用2H-香豆素及其衍生物的公式(I)和/或公式(II)，其中R1和R2分别独立于H或C1-11-烷基或(CH2)n— OH，其中n为1至6之间的整数，或者R1和R2一起代表一个酮基，且其中R3、R4、R5和R6分别独立于H或C1-6-烷基或C1-6-烷氧基，R7为H或C1-6-烷基，作为抗氧化剂，特别是在饲料中，如宠物食品和饲料成分，如鱼粉、昆虫粉和禽畜粉，以及PUFA含量较高的油，如海洋油、微生物油、真菌油、藻类油和富含PUFA的植物油。本发明还涉及含有这些2H-香豆素及其衍生物的公式(I)和/或公式(II)的饲料成分和饲料，用于昆虫、水生动物和陆生动物。

  公开号：

  WO2019185898A1

文献信息

• Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as
  申请人：Merck & Co., Inc.

  公开号：US04537903A1

  公开（公告）日：1985-08-27

  Substituted cinnamyl-2,3-dihydrobenzofurans and analogs were prepared from the nucleophilic substitution of a cinnamylhalide with a 2,3-dihydrobenzofuran anion or an analog thereof. These compounds were found to be potent topical anti-inflammatory agents.

  将亚苄基-2,3-二氢苯并呋喃及类似物制备自亚苄卤代物与2,3-二氢苯并呋喃阴离子或其类似物的亲核取代反应。这些化合物被发现是有效的局部抗炎药物。
• Dendrimers as molecular translocators
  申请人：Goodman Murray

  公开号：US20060216265A1

  公开（公告）日：2006-09-28

  Transport molecules include a dendrimer and a biologically active molecule. The dendrimer of such transport molecules includes at least one guanidine group, at least one protonated guanidine group, at least one protected guanidine group, at least one amidine group, at least one protonated amidine group, at least one protected amidine group, at least one ureido group, at least one protonated ureido group, at least one protected ureido group, at least one thioureido group, at least one protonated thioureido group, or at least one protected thioureido group. The biologically active molecule is bonded to the dendrimer. A method of increasing the bioavailability of a drug includes bonding the drug to a dendrimer of the invention.

  转运分子包括一种树枝状聚合物和一种生物活性分子。这些转运分子的树枝状聚合物包括至少一个胍基团、至少一个质子化的胍基团、至少一个保护的胍基团、至少一个酰胺基团、至少一个质子化的酰胺基团、至少一个保护的酰胺基团、至少一个脲基团、至少一个质子化的脲基团、至少一个保护的脲基团、至少一个硫脲基团、至少一个质子化的硫脲基团，或至少一个保护的硫脲基团。生物活性分子与树枝状聚合物结合。一种增加药物生物利用度的方法包括将药物与本发明的树枝状聚合物结合。
• [EN] NOVEL USE OF SUBSTITUTED 2H-CHROMENS AND THEIR DERIVATIVES<br/>[FR] NOUVELLE UTILISATION DES 2H-CHROMÈNES SUBSTITUÉS ET DE LEURS DÉRIVÉS
  申请人：DSM IP ASSETS BV

  公开号：WO2019185898A1

  公开（公告）日：2019-10-03

  The present invention is directed towards the use of 2H-chromens and their derivatives of formula (I) and/or of formula (II) wherein R1 and R2 are independently from each other H or C1-11-alkyl or (CH2)n— OH with n being an integer from 1 to 6 or R1 and R2 together represent a keto group, and wherein R3, R4, R5, and R6 are independently from each other H or C1-6-alkyl or C1-6-alkoxy, and R7 is H or C1-6-alkyl, as antioxidants, especially in feed such as pet food and feed ingredients such as fish meal, insect meal and poultry meal, as well as PUFA-containing oil such as marine oil, microbial oil, fungal oil, algal oil and PUFA-containing plant oil. The present invention is further directed towards feed ingredients and feed for insects, aquatic and terrestrial animals comprising such 2H- chromens and their derivatives of formula (I) and/or of formula (II).

  本发明涉及使用2H-香豆素及其衍生物的公式(I)和/或公式(II)，其中R1和R2分别独立于H或C1-11-烷基或(CH2)n— OH，其中n为1至6之间的整数，或者R1和R2一起代表一个酮基，且其中R3、R4、R5和R6分别独立于H或C1-6-烷基或C1-6-烷氧基，R7为H或C1-6-烷基，作为抗氧化剂，特别是在饲料中，如宠物食品和饲料成分，如鱼粉、昆虫粉和禽畜粉，以及PUFA含量较高的油，如海洋油、微生物油、真菌油、藻类油和富含PUFA的植物油。本发明还涉及含有这些2H-香豆素及其衍生物的公式(I)和/或公式(II)的饲料成分和饲料，用于昆虫、水生动物和陆生动物。
• Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
  申请人：Medinox, Inc.

  公开号：US20030181495A1

  公开（公告）日：2003-09-25

  The present invention provides novel combinations of dithiocarbamate disulfide dimers with other active agents. In one method, the disulfide derivative of a dithiocarbamate is coadministered with a thiazolidinedione for the treatment of diabetes. In another embodiment, In another embodiment, invention combinations further comprise additional active agents such as, for example, metformin, insulin, sulfonylureas, and the like. In another embodiment, the present invention relates to compositions and formulations useful in such therapeutic methods.

  本发明提供了二硫代氨基甲酸盐二硫化二聚体与其他活性药剂的新组合。在一种方法中，二硫代氨基甲酸盐的二硫化衍生物与噻唑烷二酮联合用于治疗糖尿病。在另一实施例中，该发明的组合进一步包括额外的活性药剂，例如二甲双胍、胰岛素、磺酰脲类药物等。在另一实施例中，本发明涉及用于这种治疗方法的组合物和配方。
• 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles
  申请人：Tsubouchi Hidetsugu

  公开号：US20060094767A1

  公开（公告）日：2006-05-04

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group —OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and —(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis , multi-drug-resistant Mycobacterium tuberculosis , and atypical acid-fast bacteria.

  本发明提供了一种2,3-二氢-6-硝基咪唑并[2,1-b]噁唑化合物，其通式如下：其中，R1代表氢原子或C1-C6烷基，n代表0到6的整数，R2代表—OR3或类似的基团，R3代表氢原子、C1-C6烷基或类似的基团，或者R1和—(CH2)nR2可以通过相邻的碳原子通过氮原子结合在一起形成一个螺环，其通式为（H）：其中，R41为氢、C1-C6烷基或类似的基团。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型酸性快速细菌具有优异的杀菌作用。