N-[(propylamino)carbonyl]-4-(6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl) benzenesulfonamide | 1217886-36-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(propylamino)carbonyl]-4-(6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl) benzenesulfonamide
• 英文别名: 1-[4-(6-Oxo-3-phenyl-4,5-dihydropyridazin-1-yl)phenyl]sulfonyl-3-propylurea
• CAS: 1217886-36-6
• 化学式: C₂₀H₂₂N₄O₄S
• 分子量: 414.485
• InChiKey: YUVIPXSNAGMBAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  正丙胺 、 ethyl {[4-(6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl)phenyl]sulfonyl}carbamate 以 甲苯 为溶剂， 反应 3.0h， 以49%的产率得到N-[(propylamino)carbonyl]-4-(6-oxo-3-phenyl-5,6-dihydropyridazin-1(4H)-yl) benzenesulfonamide
  参考文献：
  名称：

  Synthesis and Blood Glucose Lowering Activity of Novel Benzenesulfonyl-Urea Derivatives

  摘要：

  Treatment of the pyridazinone derivatives (1a, 1b) with ethyl chloroformate afforded novel carbamates (2a, 2b). Subsequent treatment of 2a, 2b with appropriate amines gave novel benzenesulfonylurea derivatives (3a-i). All these compounds were characterized on the basis of (1)H NMR, IR, Mass spectral data and elemental analysis results. Preliminary biological testing of urea derivatives revealed that some compounds possess significant blood sugar lowering activity. Four compounds (3c, 3f, 3g, and 3h) were found to have promising blood glucose lowering activity and may be used as lead compounds for developing new antidiabetic drugs.

  DOI：

  10.1080/10426500802467187

文献信息

• Synthesis and Blood Glucose Lowering Activity of Novel Benzenesulfonyl-Urea Derivatives
  作者：Shamim Ahmad、Kalim Javed、I. G. Rathish、Sameena Bano、M. S. Alam

  DOI：10.1080/10426500802467187

  日期：2009.10.13

  Treatment of the pyridazinone derivatives (1a, 1b) with ethyl chloroformate afforded novel carbamates (2a, 2b). Subsequent treatment of 2a, 2b with appropriate amines gave novel benzenesulfonylurea derivatives (3a-i). All these compounds were characterized on the basis of (1)H NMR, IR, Mass spectral data and elemental analysis results. Preliminary biological testing of urea derivatives revealed that some compounds possess significant blood sugar lowering activity. Four compounds (3c, 3f, 3g, and 3h) were found to have promising blood glucose lowering activity and may be used as lead compounds for developing new antidiabetic drugs.