(2R)-2-methoxypyrrolidine | 186393-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2R)-2-methoxypyrrolidine
• CAS: 186393-30-6
• 化学式: C₅H₁₁NO
• 分子量: 101.148
• InChiKey: MUWAEBAXEVXDRT-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氯-5-乙酰基吡啶 、 (2R)-2-methoxypyrrolidine 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Pyridopyrimidine analogues as novel adenosine kinase inhibitors

  摘要：

  A novel series of pyridopyrimidine analogues 9 was identified as potent adenosine kinase inhibitors based on the SAR and computational studies. Substitution of the C7 position of the pyridopyrimidino core with C2 ' substituted pyridino moiety increased the in vivo potency and enhanced oral bioavailability of these adenosine kinase inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00375-4

文献信息

• Pyridopyrimidine analogues as novel adenosine kinase inhibitors
  作者：Guo Zhu Zheng、Chih-Hung Lee、John K Pratt、Richard J Perner、Mei Qun Jiang、Arthur Gomtsyan、Mark A Matulenko、Yui Mao、John R Koenig、Ki H Kim、Steve Muchmore、Haixia Yu、Kathy Kohlhaas、Karen M Alexander、Steve McGaraughty、Katharine L Chu、Carol T Wismer、Joseph Mikusa、Michael F Jarvis、Kennan Marsh、Elizabeth A Kowaluk、Shripad S Bhagwat、Andrew O Stewart

  DOI：10.1016/s0960-894x(01)00375-4

  日期：2001.8

  A novel series of pyridopyrimidine analogues 9 was identified as potent adenosine kinase inhibitors based on the SAR and computational studies. Substitution of the C7 position of the pyridopyrimidino core with C2 ' substituted pyridino moiety increased the in vivo potency and enhanced oral bioavailability of these adenosine kinase inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.