1-(6'-Phenylhexyl)-4-(10'-cis-nonadecenyl) pyridinium Bromide | 474379-90-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(6'-Phenylhexyl)-4-(10'-cis-nonadecenyl) pyridinium Bromide
• 英文别名: 4-[(Z)-nonadec-10-enyl]-1-(6-phenylhexyl)pyridin-1-ium;bromide
• CAS: 474379-90-3
• 化学式: Br*C₃₆H₅₈N
• 分子量: 584.767
• InChiKey: HBGSRRBOWAMYLV-KVVVOXFISA-M

计算性质

• 辛醇/水分配系数(LogP)：
  7.75
• 重原子数：
  38
• 可旋转键数：
  24
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-(10'-cis)-nonadecenyl pyridine 、 1-溴-6-苯基己烷 以 甲醇 、 乙醚 、 氯仿 为溶剂， 生成 1-(6'-Phenylhexyl)-4-(10'-cis-nonadecenyl) pyridinium Bromide
  参考文献：
  名称：

  Cationic amphiphiles, preparation and method for transfection

  摘要：

  本发明涉及一种具有芳环并含有至少一个氮原子的新型阳离子两性分子。这种阳离子两性分子特别适用于将生物活性化合物如DNA、RNA、蛋白质等引入真核细胞中。该阳离子两性分子由以下基本公式表示：其特点是R1和R2为单一的C6-C24碳链。对于其作用方式，假定R1向后折叠到芳环上并朝向R2。

  公开号：

  EP1254896A1

文献信息

• Delivery of a substance to a pre-determinated site
  申请人：Applied NanoSystems B.V.

  公开号：EP1350507A1

  公开（公告）日：2003-10-08

  The invention is concerned with delivery vehicles for delivering a substance of interest to a predetermined site, said vehicle comprising said substance and a means for inducing availability of at least one compartment of said vehicle toward the exterior, thereby allowing access of said substance to the exterior of said vehicle at said predetermined site. The invention is further concerned with uses of said vehicle and methods for preparing it.

  该发明涉及用于将感兴趣的物质传递到预定地点的运输车辆，该车辆包括该物质和一种用于诱导至少一个车辆隔间朝向外部可用的手段，从而允许在该预定地点将该物质访问到车辆外部。该发明还涉及使用该车辆的方法和制备方法。
• Delivery of a substance to a pre-determined site
  申请人：Friesen Heinz Edward Robert

  公开号：US20050272677A1

  公开（公告）日：2005-12-08

  The invention is directed to delivery vehicles for delivering a substance of interest to a predetermined site. The delivery vehicle includes a substance and means for inducing availability of at least one compartment of the delivery vehicle toward the exterior, thus, allowing access of the substance to the exterior of the delivery vehicle at the predetermined site. The invention is further directed to uses of the delivery vehicle and methods for preparing the delivery vehicle.

  本发明涉及用于将所需物质传递至预定地点的传递车辆。该传递车辆包括物质和诱导至少一个传递车辆隔室向外部可用的手段，从而允许在预定地点将物质访问到传递车辆的外部。本发明还涉及传递车辆的用途和制备传递车辆的方法。
• Cationic amphiphiles as transfection vehicles
  申请人：——

  公开号：US20040259823A1

  公开（公告）日：2004-12-23

  The invention relates to novel cationic amphiphiles having an aromatic ring comprising at least one nitrogen atom. The cationic amphiphiles are particularly useful for the introduction of biologically compounds such as DNA, RNA, proteins and the like into eukaryotic cells. The cationic amphiphiles are represented by the following basic formula:(I). Characteristic is that R 1 and R 2 ?are single C6-C24 carbon chains. For the mode of action it is assumed that R 1 folds back over the aromatic ring towards R 2 . 1

  本发明涉及新型阳离子两亲化合物，其芳香环至少包含一个氮原子。这种阳离子两亲化合物特别适用于将 DNA、RNA、蛋白质等生物化合物引入真核细胞。阳离子双亲化合物由以下基本式表示：(I)。其特点是 R 1 和 R 2 是单个 C6-C24 碳链。关于作用方式，假定 R 1 在芳香环上向 R 2 . 1
• CATIONIC AMPHIPHILES AS TRANSFECTION VEHICLES
  申请人：Applied NanoSystems B.V.

  公开号：EP1383745A1

  公开（公告）日：2004-01-28
• DELIVERY OF A SUBSTANCE TO A PRE-DETERMINED SITE
  申请人：Applied NanoSystems B.V.

  公开号：EP1490028A1

  公开（公告）日：2004-12-29