2-[(2-Aminoethyl)sulfanyl]-4-methyl-1,3-thiazole | 446829-74-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[(2-Aminoethyl)sulfanyl]-4-methyl-1,3-thiazole
• 英文别名: 2-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]ethanamine
• CAS: 446829-74-9
• 化学式: C₆H₁₀N₂S₂
• mdl: MFCD03011576
• 分子量: 174.3
• InChiKey: FCUGWJFFEZQETO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-acylsulfonamide apoptosis promoters
  申请人：Abbott Laboratories

  公开号：EP2308812A2

  公开（公告）日：2011-04-13

  Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.

  本发明公开了抑制抗细胞凋亡蛋白家族成员活性的 N-酰基磺酰胺化合物、含有该化合物的组合物以及该化合物用于制备治疗一种或多种抗细胞凋亡蛋白家族成员表达的疾病的药物的用途。
• Apoptosis promoters
  申请人：Bruncko Milan

  公开号：US20060128706A1

  公开（公告）日：2006-06-15

  Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

  本发明公开了抑制抗凋亡蛋白家族成员活性的化合物、含有这些化合物的组合物以及这些化合物用于制备治疗疾病的药物的用途，在这些疾病中，一种或一种以上的抗凋亡蛋白家族成员发生表达。
• N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS
  申请人：AbbVie Bahamas Ltd.

  公开号：EP1685119B1

  公开（公告）日：2016-03-09
• APOPTOSIS PROMOTERS
  申请人：Bruncko Milan

  公开号：US20100022773A1

  公开（公告）日：2010-01-28

  Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
• ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
  申请人：Baell Jonathan Bayldon

  公开号：US20110098305A1

  公开（公告）日：2011-04-28

  Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.