neopentylhydrazine | 66557-70-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: neopentylhydrazine
• 英文别名: 2,2-dimethylpropylhydrazine；Neopentylhydrazin
• CAS: 66557-70-8
• 化学式: C₅H₁₄N₂
• 分子量: 102.18
• InChiKey: ADMTUGZFHLWYAU-UHFFFAOYSA-N

物化性质

• 沸点：
  158.4±9.0 °C(Predicted)
• 密度：
  0.826±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  neopentylhydrazine 在 lithium hydroxide monohydrate 、 叠氮磷酸二苯酯 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 水 、 甲苯 为溶剂， 反应 17.0h， 生成 tert-butyl N-[1-(2,2-dimethylpropyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl]carbamate
  参考文献：
  名称：

  [EN] MALT1 MODULATORS AND USES THEREOF
  [FR] MODULATEURS DE MALT1 ET LEURS UTILISATIONS

  摘要：

  Provided herein are compounds, compositions, and methods useful for modulating MALT1 and for treating related diseases, disorders, and conditions.

  公开号：

  WO2023192506A1
• 作为产物：
  描述：

  Azoxy-2,2-dimethylpropan 在 盐酸 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 neopentylhydrazine
  参考文献：
  名称：

  Biela,R. et al., Journal fur praktische Chemie (Leipzig 1954), 1967, vol. 36, p. 197 - 201

  摘要：

  DOI：

文献信息

• Pyridazinone compounds
  申请人：Taniguchi Takahiko

  公开号：US20100197651A1

  公开（公告）日：2010-08-05

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ): wherein R 1 represents a substituent, R 2 represents a hydrogen atom, or a substituent, R 3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供了一种具有PDE抑制作用并且用作预防或治疗精神分裂症等病症的药物的化合物。该化合物的公式为(I0)：其中，R1代表一个取代基，R2代表一个氢原子或一个取代基，R3代表一个氢原子或一个取代基，环A代表一个可被取代的芳香环，而环B代表一个可被取代的5元杂芳环，或其盐。
• PYRIDAZINONE COMPOUNDS
  申请人：TANIGUCHI Takahiko

  公开号：US20120277204A1

  公开（公告）日：2012-11-01

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供了一种具有PDE抑制作用的化合物，可用作预防或治疗精神分裂症等药物。化合物的式子为(I0)，其中R1代表取代基；R2代表氢原子或取代基；R3代表氢原子或取代基；环A代表可取代的芳香环，环B代表可取代的五元杂环芳基环或其盐。
• 1-phenyl-3-pyrazolylpyridazin-4(1H)-one compound
  申请人：Taniguchi Takahiko

  公开号：US08354411B2

  公开（公告）日：2013-01-15

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0), wherein R1 represents a substituent; R2 represents a hydrogen atom, or a substituent; R3 represents a hydrogen atom, or a substituent; Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供了一种具有PDE抑制作用的化合物，可用作预防或治疗精神分裂症等药物。该化合物的化学式为（I0），其中R1代表取代基；R2代表氢原子或取代基；R3代表氢原子或取代基；环A代表可以被取代的芳香环，环B代表可以被取代的五元杂环芳香环，或其盐。
• Pyridazinone compounds as phosphodiesterase inhibitors and methods of treating disorders
  申请人：Taniguchi Takahiko

  公开号：US08916566B2

  公开（公告）日：2014-12-23

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0): wherein R1 represents a substituent, R2 represents a hydrogen atom, or a substituent, R3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供一种具有PDE抑制作用的化合物，可用作预防或治疗精神分裂症等药物。化合物的化学式（I0）如下： 其中，R1代表取代基，R2代表氢原子或取代基，R3代表氢原子或取代基，环A代表可被取代的芳香环，环B代表可被取代的五元杂环芳香环，或其盐。
• PYRIDAZINONE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS AND METHODS OF TREATING DISORDERS
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20150099757A1

  公开（公告）日：2015-04-09

  The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I 0 ): wherein R 1 represents a substituent, R 2 represents a hydrogen atom, or a substituent, R 3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.

  本发明提供了一种具有PDE抑制作用的化合物，可用作预防或治疗精神分裂症等药物。该化合物的化学式为（I0），其中R1代表取代基，R2代表氢原子或取代基，R3代表氢原子或取代基，环A代表可被取代的芳香环，环B代表可被取代的五元杂环芳香环，或其盐。