1-(4,5-dihydrothiazol-2-yl)-amino-1-(2,3-dichlorophenyl)-2-(3,5-dimethyl-phenyl)-ethane | 1050433-40-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(4,5-dihydrothiazol-2-yl)-amino-1-(2,3-dichlorophenyl)-2-(3,5-dimethyl-phenyl)-ethane
• 英文别名: 1-(4,5-Dihydrothiazol-2-yl)amino-1-(2,3-dichlorophenyl)-2-(3,5-dimethylphenyl)-ethane；N-[1-(2,3-dichlorophenyl)-2-(3,5-dimethylphenyl)ethyl]-4,5-dihydro-1,3-thiazol-2-amine
• CAS: 1050433-40-3
• 化学式: C₁₉H₂₀Cl₂N₂S
• 分子量: 379.353
• InChiKey: WYFRLQWMGCUEPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(3-溴丙氧基)四氢-2H-吡喃 、 1-(4,5-dihydrothiazol-2-yl)-amino-1-(2,3-dichlorophenyl)-2-(3,5-dimethyl-phenyl)-ethane 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 生成 1-{3-[3-(tetrahydropyran-2-yloxy)propyl]thiazolidin-2-ylidene}amino-1-(2,3-dichlorophenyl)-2-(3,5-dimethylphenyl)-ethane
  参考文献：
  名称：

  [EN] 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS
  [FR] COMPOSÉS 1-(AZOLIN-2-YL)AMINO-1,2-DIPHÉNYLÉTHANE POUR LUTTER CONTRE LES ANIMAUX NUISIBLES

  摘要：

  本发明涉及公式I的1-(咪唑啉-2-基)氨基-1,2-二苯乙烷化合物及其盐，用于防治动物害虫。本发明还涉及使用这些化合物控制动物害虫的方法，种子以及包含所述化合物的农业和兽医组合物，其中A是公式A.1或A.2的基团，其中#表示与公式I的其余化合物的键合，X从O、S和NRx中选择，R1从由-ORA、-NRB1RB2、-C（=O）-RC、-C（=O）-ORD、-C（=O）-SRE、-C（=O）-NRB1RB2'、-C（=S）-RC'、-C（=S）-ORD'、-C（=S）-SRE'、-C（=S）-NRB1RB2、-C（=NR1a）-RC'、-C（=NR1b）-ORD'、-C（=NR1c）-SRE'、-C（=NR1d）-NRB1RB2、-S（=O）-RF、-S（=O）2-RG、-S（=O）2-NRB1RB2'、-P（=O）RH1RH2、-P（=S）RH1RH2、-B-C（=O）-RI、-B-O-C（=O）-RI、-B-S-C（=O）-RI、-B-N（RJ）-C（=O）-RK、-B-C（=S）-RK、-B-O-C（=S）-RK、-B-S-C（=S）-RK、-B-N（RJ）-C（=S）-RK、C1-C8-烯丙基、C1-C8-炔基、C3-C8-环烷基，未取代或可携带1至4个取代基R1e，萘基，未取代或可携带1至4个取代基R1f，饱和或部分不饱和的杂环，未取代或可携带1至4个取代基R1g，杂芳基，未取代或可携带1至4个取代基R1h，以及C1-C6-烷基，携带从由-NR1iR1j、C1-C4-烷氧羰基、C3-C8-环烷基、芳基、芳氧基、芳硫基、杂环基、杂环氧基和杂环硫基选择的基团，R2、R3、R4、R5、R6和R7各自独立地为氢、卤素、OH、SH、NH2、SO3H、COOH、氰基、硝基、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基等。

  公开号：

  WO2009004032A1

文献信息

• Pesticidal Active Mixtures Comprising Aminothiazoline Compounds
  申请人：Langewald Jürgen

  公开号：US20100056469A1

  公开（公告）日：2010-03-04

  Pesticidal mixtures comprising aminothiazoline compounds The present invention relates to pesticidal mixtures comprising as active compounds 1) at least one aminothiazoline compound I of the Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are defined in the description; and 2) at least one active compound II selected from a group A comprising acetylcholine esterase inhibitors, GABA-gated chloride channel antagonists, sodium channel modulators, nicotinic acetylcholine receptor agonists/antagonists, chloride channel activators, juvenile hormone mimics, compounds affecting the oxidative phosphorylation, inhibitors of the chitin biosynthesis, moulting disruptors, inhibitors of the MET, voltage-dependent sodium channelblockers, inhibitors of the lipidsynthesis and other compounds as defined in the description, in synergistically effective amounts. The invention relates further to methods and use of these mixtures for combating insects, arachnids or nematodes in and on plants, and for protecting such plants being infested with pests, especially also for protecting seeds.

  本发明涉及一种杀虫混合物，其包括以下活性化合物：1）至少一种公式（I）中的氨基噻唑化合物I，其中R1、R2、R3、R4、R5和R6在说明书中定义；以及2）至少一种来自A组的活性化合物II，该组包括乙酰胆碱酯酶抑制剂、GABA门控氯离子通道拮抗剂、钠通道调节剂、烟碱型乙酰胆碱受体激动剂/拮抗剂、氯离子通道激活剂、幼虫激素类似物、影响氧化磷酸化的化合物、几丁质生物合成抑制剂、蜕皮干扰剂、MET抑制剂、电压依赖性钠通道阻滞剂、脂质合成抑制剂和根据说明书定义的其他化合物，其在协同有效量下。本发明还涉及使用这些混合物对植物上的昆虫、蜘蛛或线虫进行防治，并保护被害虫侵害的这些植物，尤其是保护种子的方法和用途。
• 1-(Azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests
  申请人：Kordes Markus

  公开号：US20100280078A1

  公开（公告）日：2010-11-04

  The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and to their salts which are useful for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds. wherein A is a radical of formulae A.1 or A.2 wherein # denotes the bond to the remaining compound of formula I, X is selected from O, S and NR X , R 1 is selected from the group consisting of —OR A , —NR B1 R B2 , C(═O)—R C , —C(═O)—OR D , —C(═O)—SR E , —C(═O)—NR B1 R B2 ′, —C(═S)—R C ′, —C(═S)—OR D ′, —C(═S)—SR E ′, —C(═S)—NR B1 R B2 , —C(═NR 1a )—R C ′, —C(═NR 1b )—OR D ′, —C(═NR 1c )—SR E ′, —C(═NR 1d )—NR B1 R B2 , —S(═O)—R F , —S(═O) 2 —R G , —S(═O) 2 —NR B1 R B2 ′, —P(═O)R H1 R H2 , —P(═S)R H1 R H2 , —B—C(═O)—R I , —B—O—C(═O)—R I , —B—S—C(═O)—R I , —B—N(R J )—C(═O)—R K , —B—C(═S)—R K , —B—O—C(═S)—R K , —B—S—C(═S)—R K , —B—N(R J )—C(═S)—R K , C 1 -C 8 -alkenyl, C 1 -C 8 -alkynyl, C 3 -C 8 -cycloalkyl, which is unsubstituted or may carry 1 to 4 substituents R 1e , naphthyl, which is unsubstituted or may carry 1 to 4 substituents R 1f , a saturated or partially unsaturated heterocycle, which is unsubstituted or may carry 1 to 4 substituents R 1g , hetaryl, which is unsubstituted or may carry 1 to 4 substituents R 1h , and C 1 -C 6 -alkyl, which carries a radical selected from the group consisting of —NR 1i R 1j , C 1 -C 4 -alkoxycarbonyl, C 3 -C 8 -cycloalkyl, aryl, aryloxy, arylthio, heterocyclyl, heterocyclyloxy and heterocyclylthio, R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are each independently hydrogen, halogen, OH, SH, NH 2 , SO 3 H, COOH, cyano, nitro, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino etc.

  本发明涉及公式I的1-(噁唑-2-基)氨基-1,2-二苯乙烷化合物及其盐，用于对抗动物害虫。本发明还涉及使用这些化合物控制动物害虫的方法，种子以及包括所述化合物的农业和兽医组合物。其中A是公式A.1或A.2的基团，#表示与公式I的其余化合物的键，X从O、S和NRX中选择，R1从—ORA、—NRB1RB2、C(═O)—RC、—C(═O)—ORD、—C(═O)—SRE、—C(═O)—NRB1RB2′、—C(═S)—RC′、—C(═S)—ORD′、—C(═S)—SRE′、—C(═S)—NRB1RB2、—C(═NR1a)—RC′、—C(═NR1b)—ORD′、—C(═NR1c)—SRE′、—C(═NR1d)—NRB1RB2、—S(═O)—RF、—S(═O)2—RG、—S(═O)2—NRB1RB2′、—P(═O)RH1RH2、—P(═S)RH1RH2、—B—C(═O)—RI、—B—O—C(═O)—RI、—B—S—C(═O)—RI、—B—N(RJ)—C(═O)—RK、—B—C(═S)—RK、—B—O—C(═S)—RK、—B—S—C(═S)—RK、—B—N(RJ)—C(═S)—RK、C1-C8-烯丙基、C1-C8-炔基、C3-C8-环烷基，未取代或可携带1至4个取代基R1e，萘基，未取代或可携带1至4个取代基R1f，饱和或部分不饱和的杂环，未取代或可携带1至4个取代基R1g，杂芳基，未取代或可携带1至4个取代基R1h，以及携带从—NR1iR1j、C1-C4-烷氧羰基、C3-C8-环烷基、芳基、芳氧基、芳硫基、杂环基、杂环氧基和杂环硫基中选择的基团的C1-C6-烷基，R2、R3、R4、R5、R6和R7各自独立地为氢、卤素、OH、SH、NH2、SO3H、COOH、氰基、硝基、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基等。
• 1-(azolin-2-yl)amino-1,2-diphenylethane compounds for combating animal pests
  申请人：BASF SE

  公开号：US08211924B2

  公开（公告）日：2012-07-03

  The present invention relates to 1-(azolin-2-yl)amino-1,2-diphenylethane compounds of the formula I and to their salts which are useful for combating animal pests. The invention also relates to a method for controlling animal pests by using these compounds, to seed and to an agricultural and veterinary composition comprising said compounds. wherein A is a radical of formulae A.1 or A.2 wherein # denotes the bond to the remaining compound of formula I, X is selected from O, S and NRX, R1 is selected from the group consisting of —ORA, —NRB1RB2, —C(═O)—RC, —C(═O)—ORD, —C(═O)—SRE, —C(═O)—NRB1RB2′, —C(═S)—RC′, —C(═S)—ORD′, —C(═S)—SRE′, —C(═S)—NRB1RB2, —C(═NR1a)—RC′, —C(═NR1b)—ORD′, —C(═NR1c)—SRE′, —C(═NR1d)—NRB1RB2, —S(═O)—RF, —S(═O)2—RG, —S(═O)2—NRB1RB2′, —P(═O)RH1RH2, —P(═S)RH1RH2, —B—C(═O)—RI, —B—O—C(═O)—RI, —B—S—C(═O)—RI, —B—N(RJ)—C(═O)—RK, —B—C(═S)—RK, —B—O—C(═S)—RK, —B—S—C(═S)—RK, —B—N(RJ)—C(═S)—RK, C1-C8-alkenyl, C1-C8-alkynyl, C3-C8-cycloalkyl, which is unsubstituted or may carry 1 to 4 substituents R1e, naphthyl, which is unsubstituted or may carry 1 to 4 substituents R1f, a saturated or partially unsaturated heterocycle, which is unsubstituted or may carry 1 to 4 substituents R1g, hetaryl, which is unsubstituted or may carry 1 to 4 substituents R1h, and C1-C6-alkyl, which carries a radical selected from the group consisting of —NR1iR1j, C1-C4-alkoxycarbonyl, C3-C8-cycloalkyl, aryl, aryloxy, arylthio, heterocyclyl, heterocyclyloxy and heterocyclylthio, R2, R3, R4, R5, R6 and R7 are each independently hydrogen, halogen, OH, SH, NH2, SO3H, COOH, cyano, nitro, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino etc.

  本发明涉及公式I的1-(咪唑啉-2-基)氨基-1,2-二苯乙烷化合物及其盐，用于对抗动物害虫。本发明还涉及使用这些化合物控制动物害虫的方法，种子以及包含上述化合物的农业和兽医组合物。其中A是公式A.1或A.2的基团，#表示与公式I的其余化合物的键，X选自O、S和NRX，R1选自—ORA、—NRB1RB2、—C(═O)—RC、—C(═O)—ORD、—C(═O)—SRE、—C(═O)—NRB1RB2'、—C(═S)—RC'、—C(═S)—ORD'、—C(═S)—SRE'、—C(═S)—NRB1RB2、—C(═NR1a)—RC'、—C(═NR1b)—ORD'、—C(═NR1c)—SRE'、—C(═NR1d)—NRB1RB2、—S(═O)—RF、—S(═O)2—RG、—S(═O)2—NRB1RB2'、—P(═O)RH1RH2、—P(═S)RH1RH2、—B—C(═O)—RI、—B—O—C(═O)—RI、—B—S—C(═O)—RI、—B—N(RJ)—C(═O)—RK、—B—C(═S)—RK、—B—O—C(═S)—RK、—B—S—C(═S)—RK、—B—N(RJ)—C(═S)—RK、C1-C8-烯丙基、C1-C8-炔基、未取代或可携带1至4个R1e取代基的C3-C8-环烷基、未取代或可携带1至4个R1f取代基的萘基、未取代或可携带1至4个R1g取代基的饱和或部分不饱和的杂环、未取代或可携带1至4个R1h取代基的杂芳基以及携带从群组- NR1iR1j、C1-C4-烷氧羰基、C3-C8-环烷基、芳基、芳氧基、芳硫基、杂环基、杂环氧基和杂环硫基中选择的基团的C1-C6-烷基，其中R2、R3、R4、R5、R6和R7各自独立地为氢、卤素、OH、SH、NH2、SO3H、COOH、氰基、硝基、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基等。
• PESTICIDAL ACTIVE MIXTURES COMPRISING AMINOTHIAZOLINE COMPOUNDS
  申请人：BASF SE

  公开号：EP2063711A1

  公开（公告）日：2009-06-03
• 1-(AZOLIN-2-YL)AMINO-1,2-DIPHENYLETHANE COMPOUNDS FOR COMBATING ANIMAL PESTS
  申请人：BASF SE

  公开号：EP2176232A1

  公开（公告）日：2010-04-21