5-morpholinofur-2-ylmethanol | 869942-23-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-morpholinofur-2-ylmethanol
• 英文别名: (5-Morpholinofuran-2-yl)methanol；(5-morpholin-4-ylfuran-2-yl)methanol
• CAS: 869942-23-4
• 化学式: C₉H₁₃NO₃
• mdl: MFCD09754762
• 分子量: 183.207
• InChiKey: GQAXCIQPIXHMNQ-UHFFFAOYSA-N

物化性质

• 沸点：
  360.1±42.0 °C(Predicted)
• 密度：
  1.226±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-morpholinofur-2-ylmethanol 、 马来酸二乙酯 以 甲苯 为溶剂， 以25%的产率得到1,3-dihydro-5-(4-morpholinyl)-3-oxo-4-isobenzofurancarboxylic acid ethyl ester
  参考文献：
  名称：

  First Entry to [4+2] Cycloadditions Involving 5-Amino-2-furanmethanols

  摘要：

  The preparation of new 5-amino-2-furanmethanols bearing various amino and primary or secondary alcohol groups is described. The structures of 5-amino-2-furanmethanols as dienes are consistent with (1)H NMR data and cyloadditions of them allows the selective synthesis of tetrasubstituted aminobenzylic alcohols, amino phenols or lactones through Diels-Alder reactions.

  DOI：

  10.3987/com-08-11556
• 作为产物：
  描述：

  5-吗啉-4-基-2-呋喃甲醛 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以100%的产率得到5-morpholinofur-2-ylmethanol
  参考文献：
  名称：

  First Entry to [4+2] Cycloadditions Involving 5-Amino-2-furanmethanols

  摘要：

  The preparation of new 5-amino-2-furanmethanols bearing various amino and primary or secondary alcohol groups is described. The structures of 5-amino-2-furanmethanols as dienes are consistent with (1)H NMR data and cyloadditions of them allows the selective synthesis of tetrasubstituted aminobenzylic alcohols, amino phenols or lactones through Diels-Alder reactions.

  DOI：

  10.3987/com-08-11556

文献信息

• Dihydropyridine anti-ischaemic and antihypertensive agents
  申请人：Pfizer Limited

  公开号：EP0150939A1

  公开（公告）日：1985-08-07

  1,4-Dihydropyridines of the formula: wherein R is aryl or heteroaryl; R1 and R2 are each independently C1-C4 alkyl or 2-methoxyethyl; n is 1 or 2; m is 1, 2 or 3; X is a 5 or 6 membered aromatic heterocyclic group; Z is a group -NR3R4 or a 5 or 6 membered nitrogen containing heterocyclic group; wherein R3 is H or C1-C4 alkyl; R4 is H, C1-C4 alkyl, CO(C1-C4alkyl), COCF3, CONR5R6, SO2(C1-C4 alkyl) or a heterocyclic or S02-heterocyclic group, and R5 and R are each independently H or C1-C4 alkyl or taken together with the nitrogen atom to which they are attached, they form a pyrrolidinyl, piperidyl, morpholino, piperazinyl or N-(C1-C4 alkyl) piperazinyl group; are calcium channel blockers useful as anti- isachaemic and antihypertensive agents.

  式中的 1,4-二氢吡啶： 其中 R 是芳基或杂芳基；R1 和 R2 各自独立地是 C1-C4 烷基或 2-甲氧基乙基；n 是 1 或 2；m 是 1、2 或 3；X 是 5 或 6 位芳香杂环基团；Z 是基团 -NR3R4 或 5 或 6 位含氮杂环基团；其中 R3 是 H 或 C1-C4 烷基；R4是H、C1-C4烷基、CO(C1-C4烷基)、COCF3、CONR5R6、SO2(C1-C4烷基)或杂环基团或S02-杂环基团，R5和R各自独立地是H或C1-C4烷基，或与它们所连接的氮原子一起形成吡咯烷基、哌啶基、吗啉基、哌嗪基或N-(C1-C4烷基)哌嗪基；是可用作抗异血症和抗高血压药物的钙通道阻滞剂。
• US4548935A
  申请人：——

  公开号：US4548935A

  公开（公告）日：1985-10-22
• First Entry to [4+2] Cycloadditions Involving 5-Amino-2-furanmethanols
  作者：Sylvain Marque、Damien Prim、Raouf Medimagh、Saber Chatti

  DOI：10.3987/com-08-11556

  日期：——

  The preparation of new 5-amino-2-furanmethanols bearing various amino and primary or secondary alcohol groups is described. The structures of 5-amino-2-furanmethanols as dienes are consistent with (1)H NMR data and cyloadditions of them allows the selective synthesis of tetrasubstituted aminobenzylic alcohols, amino phenols or lactones through Diels-Alder reactions.