ethyl 2,3,5,9b-tetrahydro-3,3-dimethyl-7-morpholino-5-oxooxazolo[2,3-a]isoindole-6-carboxylate | 1146445-74-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: ethyl 2,3,5,9b-tetrahydro-3,3-dimethyl-7-morpholino-5-oxooxazolo[2,3-a]isoindole-6-carboxylate
• 英文别名: Ethyl 3,3-dimethyl-7-morpholin-4-yl-5-oxo-2,9b-dihydro-[1,3]oxazolo[2,3-a]isoindole-6-carboxylate；ethyl 3,3-dimethyl-7-morpholin-4-yl-5-oxo-2,9b-dihydro-[1,3]oxazolo[2,3-a]isoindole-6-carboxylate
• CAS: 1146445-74-0
• 化学式: C₁₉H₂₄N₂O₅
• 分子量: 360.41
• InChiKey: XBUKLWBUUDREHG-UHFFFAOYSA-N

物化性质

• 熔点：
  92.5-94 °C
• 沸点：
  570.5±50.0 °C(predicted)
• 密度：
  1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-2-甲基-1-丙醇 、 马来酸二乙酯 、 5-吗啉-4-基-2-呋喃甲醛 以 甲苯 为溶剂， 反应 96.0h， 以35%的产率得到ethyl 2,3,5,9b-tetrahydro-3,3-dimethyl-7-morpholino-5-oxooxazolo[2,3-a]isoindole-6-carboxylate
  参考文献：
  名称：

  Concise Synthesis of Tricyclic Isoindolinones via One-Pot Cascade Multicomponent Sequences

  摘要：

  A series of enantiopure tricyclic isoindolinones has been successfully synthesized through a one-pot selective cascade process from furan derivatives. The synthesis is straightforward and gave good overall yields taking into account the concomitant formation of five C-C, C-O, and C-N bonds. The strategy was extended to the preparation of a thiazolidine analogue.

  DOI：

  10.1021/ol9003965

文献信息

• Concise Synthesis of Tricyclic Isoindolinones via One-Pot Cascade Multicomponent Sequences
  作者：Raouf Medimagh、Sylvain Marque、Damien Prim、Jérôme Marrot、Saber Chatti

  DOI：10.1021/ol9003965

  日期：2009.4.16

  A series of enantiopure tricyclic isoindolinones has been successfully synthesized through a one-pot selective cascade process from furan derivatives. The synthesis is straightforward and gave good overall yields taking into account the concomitant formation of five C-C, C-O, and C-N bonds. The strategy was extended to the preparation of a thiazolidine analogue.