1-(5-morpholinofur-2-yl)-1-phenylmethanol | 1144506-68-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(5-morpholinofur-2-yl)-1-phenylmethanol
• 英文别名: (5-Morpholin-4-ylfuran-2-yl)-phenylmethanol；(5-morpholin-4-ylfuran-2-yl)-phenylmethanol
• CAS: 1144506-68-2
• 化学式: C₁₅H₁₇NO₃
• 分子量: 259.305
• InChiKey: ZORWKJXVQYUVRD-UHFFFAOYSA-N

物化性质

• 沸点：
  422.3±45.0 °C(predicted)
• 密度：
  1.216±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(5-morpholinofur-2-yl)-1-phenylmethanol 、 马来酸二乙酯 以 甲苯 为溶剂， 以15%的产率得到1,3-dihydro-5-(4-morpholinyl)-3-oxo-1-phenyl-4-isobenzofurancarboxylic acid ethyl ester
  参考文献：
  名称：

  First Entry to [4+2] Cycloadditions Involving 5-Amino-2-furanmethanols

  摘要：

  The preparation of new 5-amino-2-furanmethanols bearing various amino and primary or secondary alcohol groups is described. The structures of 5-amino-2-furanmethanols as dienes are consistent with (1)H NMR data and cyloadditions of them allows the selective synthesis of tetrasubstituted aminobenzylic alcohols, amino phenols or lactones through Diels-Alder reactions.

  DOI：

  10.3987/com-08-11556
• 作为产物：
  描述：

  苯基溴化镁 、 5-吗啉-4-基-2-呋喃甲醛 以 四氢呋喃 为溶剂， 生成 1-(5-morpholinofur-2-yl)-1-phenylmethanol
  参考文献：
  名称：

  First Entry to [4+2] Cycloadditions Involving 5-Amino-2-furanmethanols

  摘要：

  The preparation of new 5-amino-2-furanmethanols bearing various amino and primary or secondary alcohol groups is described. The structures of 5-amino-2-furanmethanols as dienes are consistent with (1)H NMR data and cyloadditions of them allows the selective synthesis of tetrasubstituted aminobenzylic alcohols, amino phenols or lactones through Diels-Alder reactions.

  DOI：

  10.3987/com-08-11556

文献信息

• First Entry to [4+2] Cycloadditions Involving 5-Amino-2-furanmethanols
  作者：Sylvain Marque、Damien Prim、Raouf Medimagh、Saber Chatti

  DOI：10.3987/com-08-11556

  日期：——

  The preparation of new 5-amino-2-furanmethanols bearing various amino and primary or secondary alcohol groups is described. The structures of 5-amino-2-furanmethanols as dienes are consistent with (1)H NMR data and cyloadditions of them allows the selective synthesis of tetrasubstituted aminobenzylic alcohols, amino phenols or lactones through Diels-Alder reactions.