4-(4-methoxyphenyl)-2,6-dicoumarinylpyridine | 1062158-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(4-methoxyphenyl)-2,6-dicoumarinylpyridine
• 英文别名: 3,3'-(4-(4-methoxyphenyl)pyridine-2,6-diyl)bis(2H-chromen-2-one)；3-(4-(4-methoxyphenyl)-6-(2-oxo-2H-chromen-3-yl)pyridin-2-yl)-2H-chromen-2-one；4-(4-methoxyphenyl)-2,6-di(coumarin-3-yl)pyridine；3-[4-(4-Methoxyphenyl)-6-(2-oxochromen-3-yl)pyridin-2-yl]chromen-2-one
• CAS: 1062158-79-5
• 化学式: C₃₀H₁₉NO₅
• 分子量: 473.485
• InChiKey: MOBLQQBWWQAYCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  36
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  74.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-((2E)-3-(4-methoxyphenyl)prop-2-enoyl)-2H-chromen-2-one 在 bismuth(III) nitrate/zinc(II) chloride/alumina catalyst 尿素 作用下， 以75%的产率得到4-(4-methoxyphenyl)-2,6-dicoumarinylpyridine
  参考文献：
  名称：

  Bi(NO3)3 - Al2O3-Mediated Efficient Synthesis of 4-Aryl-2,6-dicoumarinylpyridines Under Solventless Conditions

  摘要：

  以 Bi(iii) nitrate-Al2O3 为催化剂，开发出了一种从香豆素基查耳酮和尿素合成 4-芳基-2,6-二香豆素基吡啶的高效、环保的新方法。在辅助催化剂氯化锌（Zn(ii)）的存在下，香豆素基查耳酮在 Bi(iii) nitrate-Al2O3 表面与醛发生串联反应，进而从水杨醛和乙酰乙酸乙酯制备香豆素基查耳酮。

  DOI：

  10.1071/ch07206

文献信息

• Design, synthesis, characterization, photophysical and pH chemosensor studies of novel 2,4,6-trisubstituted pyridines
  作者：Nirmala S. Naik、Navya S. Bhat、Arpana G. Hegde、Swati S. Bhat、Akshay Kirasur、Anilkumar Patil、Lokesh A. Shastri、Vinay Sunagar

  DOI：10.1080/00397911.2017.1410174

  日期：2018.3.4

  of substituted aromatic aldehydes and substituted 3-acetylcoumarin with ammonium acetate. The structures of all the new compounds were characterized by IR, NMR, and GC–MS analysis. The important photo physical prerequisites for organoelectronic such as optical absorption and thermal stability were determined for the synthesized molecules. Optical properties were studied by UV–visible absorption and

  摘要 为了在有机电子产品和 pH 计中的应用，通过取代芳香醛和取代 3-乙酰香豆素与乙酸铵反应合成了一系列新型 2,4,6-三取代吡啶。所有新化合物的结构均通过 IR、NMR 和 GC-MS 分析表征。确定了合成分子的重要光物理先决条件，例如光吸收和热稳定性。通过紫外可见吸收和荧光光谱研究了光学性质。发现 2,4,6-三取代吡啶的光学带隙约为 3.01-3.06 eV，根据它们的起始吸收边计算。荧光强度的 pH 依赖性变化表明 2,4, 6-三取代吡啶在细胞内pH计中是有用的申请人。图形概要
• A facile one-pot, three-component synthesis of 3,3′-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives under microwave irradiation
  作者：Jian-Feng Zhou、Xiao-Jun Sun、Feng-Wen Lou、Meng Lv、Lu-Lu Zhang

  DOI：10.1007/s11164-012-0696-5

  日期：2013.3

  A series of 3,3′-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives have been synthesized by the one-pot, three-component reaction of 3-acetylcoumarin, an aromatic aldehyde, and ammonium acetate in acetic acid under microwave irradiation. This procedure has the major advantages of short reaction time, good yields, low energy consumption, easy operation, and environmental friendliness. All of the products were characterized by IR and NMR spectroscopy, MS, and elemental analysis.

  以芳香族化合物3-乙酰香豆素为原料，通过一锅三组分反应合成了一系列3,3′-(4-芳基吡啶-2,6-二基)双(2H-苯并呋喃-2-酮)衍生物。微波照射下，在乙酸中生成醛和乙酸铵。该工艺具有反应时间短、收率好、能耗低、操作简便、环境友好等优点。所有产物均通过红外光谱、核磁共振光谱、质谱和元素分析进行​​表征。
• Synthesis, characterization and antimicrobial activity of some 4-aryl-2,6-di(coumarin-3-yl)pyridines
  作者：Dinker Ishwarbhai Brahmbhatt、Anil K. Patel、Niraj H. Patel、Mehul A. Patel

  DOI：10.3998/ark.5550190.0011.b03

  日期：——

  Some 4-aryl-2,6-di(coumarin-3-yl)pyridines 3a-r are synthesized by the reaction of 3coumarinoyl methyl pyridinium salts 1a-c with appropriate 1-[2H-1-benzopyran-2-on-3-yl]-3aryl-prop-2-en-1-ones 2a-f in the presence of ammonium acetate and acetic acid under the Krohnke reaction conditions. All the synthesized compounds are screened for antimicrobial activity.

  一些 4-芳基-2,6-二(香豆素-3-基)吡啶 3a-r 是通过 3-香豆素酰基甲基吡啶盐 1a-c 与适当的 1-[2H-1-苯并吡喃-2-on-3 反应合成的-yl]-3aryl-prop-2-en-1-ones 2a-f 在乙酸铵和乙酸的存在下，在 Krohnke 反应条件下。筛选所有合成的化合物的抗微生物活性。