3-(4-乙酰氨基苯基)丙-2-炔酸 | 103974-04-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(4-乙酰氨基苯基)丙-2-炔酸
• 英文名称: 3-(4-acetamidophenyl)propiolic acid
• 英文别名: 3-(4-Acetamidophenyl)prop-2-ynoic acid
• CAS: 103974-04-5
• 化学式: C₁₁H₉NO₃
• 分子量: 203.197
• InChiKey: OOKDVIRNOUPNFD-UHFFFAOYSA-N

物化性质

• 沸点：
  477.7±37.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-乙酰氨基苯基)丙-2-炔酸 生成 silver;3-(4-acetamidophenyl)prop-2-ynoate
  参考文献：
  名称：

  XIRAI, XIROYUKI;XARA, XIROSI;KAVADA, KEHN

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(4-Acetylaminophenyl)-2-pyrazolin-5-one 生成 3-(4-乙酰氨基苯基)丙-2-炔酸
  参考文献：
  名称：

  HIRAI, HIROYUKI;HARA, HIROSHI;KAWATA, KEN

  摘要：

  DOI：

文献信息

• Stereoselective Photoredox-Catalyzed Chlorotrifluoromethylation of Alkynes: Synthesis of Tetrasubstituted Alkenes
  作者：Hong Sik Han、Young Jin Lee、Young-Sik Jung、Soo Bong Han

  DOI：10.1021/acs.orglett.7b00470

  日期：2017.4.21

  CF3 and Cl source. In the mechanistic pathway for this process, generation of the CF3 radical and chloride ion occurs by Ir(ppy)3-photocatalyzed reductive decomposition of CF3SO2Cl. The synthetically important trifluoromethyl-substituted vinyl chlorides produced in this process can be readily transformed to 1,1-bis-arylalkenes by using Suzuki coupling.

  开发了一种新的光氧化还原催化的内部芳基炔烃在温和条件下使用可见光的氯三氟甲基化反应。反应以高水平的区域选择性和立体选择性进行，并利用可商购的CF 3 SO 2 Cl作为CF 3和Cl源。在该过程的机械途径中，通过Ir（ppy）3-光催化还原CF 3 SO 2 Cl发生CF 3自由基和氯离子的产生。通过使用铃木偶合，可以很容易地将在此过程中生产的具有重要合成意义的三氟甲基取代的氯乙烯转化为1,1-双-芳基烯烃。
• Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones
  作者：Yashwardhan R. Malpani、Bishyajit Kumar Biswas、Hong Sik Han、Young-Sik Jung、Soo Bong Han

  DOI：10.1021/acs.orglett.8b00410

  日期：2018.4.6

  oxidative addition of CF3 and H2O to alkynes was achieved with photoredox catalysis to obtain α-trifluoromethyl ketones via rapid enol-keto tautomerization. The reaction exhibits high functional group tolerance and regioselectivity. Heterocycles of various sizes containing CF3 were synthesized from the α-CF3-substituted diketones obtained through the protocol, thereby demonstrating the versatile applicability

  将CF 3和H 2 O直接氧化成炔烃是通过光氧化还原催化，通过快速的烯醇-酮互变异构反应获得α-三氟甲基酮。该反应表现出高的官能团耐受性和区域选择性。含CF各种尺寸的杂环3是从α-CF合成3个通过协议获得的，从而证实了该方法的适用性多功能-取代的二酮。与同位素反应的机理研究提供了对反应途径的深入了解。
• Heat-developable light-sensitive material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0177033A2

  公开（公告）日：1986-04-09

  A heat-developable light-sensitive material is described, containing a compound represented by formula (1) wherein R, represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted alkylene group, a substituted or unsubstituted cycloalkylene group, a substituted or unsubstituted alkenylene group, a substituted or uasubstituted alkynylene group, a substituted or unsubstituted aralkylene group, a substituted or unsubstituted arylene group, or a substituted or unsubstituted divalent heterocyclic group; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group; R3 represents an alkyl group, an alkoxyl group, a halogen atom, an acylamino group, a sulfonylamino group, an alkylamino group, a dialkylamino group, an alkylsulfonyl group, an arylsulfonyl group, a cyano group, a substituted or unsubstituted carbamoyl group, a substituted or unsubstituted sulfamoyl group or an alkoxycarbonyl group; X represents a divalent group selected from (wherein R4 represents a hydrogen atom, a substituted or unsubstituted alkyl group), (wherein R5 represents a substituted or unsubstituted alkyl group), and M represents an alkali metal, an alkaline earth metal, a quaternary ammonium group, or an ammonium group represented by BH (wherein B represents an organic base); is an integer of 0 to 3; and m and n are each an integer of 1 or 2, such that the electric charge of carboxylate anion is equivalent to that of M. This material is improved in activity and storage stability. That is, the material providing an image of high density and decreased fog, and which even when stored under high temperature high humidity conditions, maintained good photographic performance.

  所述的一种热显影光敏材料含有由式(1)代表的化合物 其中 R 代表氢原子、取代或未取代的烷基、取代或未取代的环烷基、取代或未取代的烯基、取代或未取代的炔基、取代或未取代的芳基、取代或未取代的芳基、取代或未取代的杂环基、取代或未取代的亚烷基、取代或未取代的环亚烷基、取代或未取代的烯基、取代或未 取代的炔基、取代或未取代的芳基、取代或未取代的二价杂环基；R2 代表氢原子、取代或未取代的烷基； R3 代表烷基、烷氧基、卤素原子、酰氨基、磺酰氨基、烷基氨基、二烷基氨基、烷基磺酰基、芳基磺酰基、氰基、取代或未取代的氨基甲酰基、取代或未取代的氨基磺酰基或烷氧羰基； X 代表选自以下各项的二价基团： 1. (其中 R4 代表氢原子、取代或未取代的烷基）、 (其中 R5 代表取代或未取代的烷基），以及 M 代表碱金属、碱土金属、季铵基团或由 BH 代表的铵基团（其中 B 代表有机碱）；是 0 至 3 的整数；m 和 n 分别是 1 或 2 的整数，从而使羧酸阴离子的电荷与 M 的电荷相等。 这种材料在活性和储存稳定性方面都有所改进。也就是说，这种材料能提供高密度图像，减少雾气，即使在高温高湿条件下储存，也能保持良好的照相性能。
• Heat developable light-sensitive material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0198356A1

  公开（公告）日：1986-10-22

  A heat developable light-sensitive material is disclosed. The material comprises a support having provided thereon at least a light-sensitive silver halide, a reducing agent, a binder and an organic silver salt of the formula: wherein R, represents a hydrogen atom or a substituted or unsubstituted alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, aryl or heterocyclic group; R2 represents a hydrogen atom or a substituted or unsubstituted alkyl group; R, represents a halogen atom, a substituted or unsubstituted alkyl, alkoxy, amino, alkylsulfonyl, arylsulfonyl, carbamoyl, sulfamoyl or alkoxycarbonyl group or a cyano group; X represents , wherein R4 represents a hydrogen atom or a substituted or unsubstituted alkyl group, , wherein R5 represents a substituted or unsubstituted alkyl group, and : and t represents 0 or an integer of from 1 to 3; and when ℓ is 2 or 3, the groups R3 may be the same or different. The material provides an image of high density with less fog in a short time even using a reduced amount of a base precursor.

  本发明公开了一种热显影光敏材料。该材料包括一种支撑物，支撑物上至少有一种光敏卤化银、一种还原剂、一种粘合剂和一种式中的有机银盐： 其中 R 代表氢原子或取代或未取代的烷基、环烷基、烯基、炔基、芳烷基、芳基或杂环基团； R2 代表氢原子或取代或未取代的烷基； R 代表卤素原子、取代或未取代的烷基、烷氧基、氨基、烷基磺酰基、芳基磺酰基、氨基甲酰基、氨基磺酰基或烷氧羰基或氰基； X 代表 其中 R4 代表氢原子或取代或未取代的烷基、 其中 R5 代表取代或未取代的烷基，和 当 ℓ 为 2 或 3 时，基团 R3 可以相同或不同。即使使用较少量的碱前体，该材料也能在短时间内提供高密度、雾少的图像。
• Silver halide color photographic material
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0394943A2

  公开（公告）日：1990-10-31

  A silver halide color photographic material comprising a support having thereon at least one silver halide emulsion layer, wherein the silver halide color photographic material contains an image forming compound represented by the following general formula (I): (Dye-X)q-Y      (I) wherein Dye represents a cyan dye group represented by the general formula (II) described below or a precursor thereof; X represents a chemical bond or a linking group; Y represents a group having a property of releasing Dye in correspondence or counter-corres­pondence to development of a light-sensitive silver salt having a latent image distributed imagewise and making a difference in diffusibility between the dye thus-­released and the compound represented by (Dye-X)q-Y; Dye and X are connected with each other by C or E in the general formula (II); and q represents an integer of 1 or 2, and when q is 2, the two groups (Dye-X) may be the same or different: wherein A represents a halogen atom, -OR¹ or -SR¹ (wherein R¹ represents an alkyl group, an aryl group or a heterocyclic group); B represents an electron withdrawing group having a Hammett's σp value of not less than 0.3; C represents a chemical bond, a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, a halogen atom, -OR⁴, -CONR⁴R⁵, -SO₂NR⁴R⁵, -N(R³)-COR₄ or -N(R³) -SO₂R₄ (wherein R³, R⁴ and R⁵ each represents a hydrogen atom or a group selected from those defined for R¹, or R⁴ and R⁵ may combine with each other to form a 5-­membered or 6-membered ring); E represents a chemical bond, a hydrogen atom, an alkyl group, a halogen atom, -OR⁴, -CONR⁴R⁵, -SO₂NR⁴R⁵, -N(R⁵)-COR⁴ or -N(R⁵)-SO₂R⁴ (wherein R⁴ and R⁵ have the same meaning as defined above); and G represents a hydroxy group or a salt thereof, or a group selected from those represented by the formula (T), (U) or (V): wherein R²¹ and R²², which may be the same or different, each represents an alkyl group, a cycloalkyl group, an alkenyl group, an aralkyl group, an aryl group, a heterocyclic group, an alkylthio group, an arylthio group, an alkoxy group, an aryloxy group or an amino group, or R²¹ and R²² may combine with each other to form a 5-membered or 6-membered ring.

  一种卤化银彩色感光材料，包括一个支撑体，支撑体上至少有一层卤化银乳剂层，其中卤化银彩色感光材料含有由下式通式(I)表示的图像形成化合物： (Dye-X)q-Y (I) 其中，染料代表由下述通式（II）表示的青色染料基团或其前体；X 代表化学键或连接基团；Y 代表一种基团，该基团具有在显影时相应或反相应地释放染料的特性，该银盐具有按图像方向分布的潜像，并使由此释放的染料与（Dye-X）q-Y 所代表的化合物之间的扩散性不同；染料和 X 在通式(II)中通过 C 或 E 相互连接；q 代表 1 或 2 的整数，当 q 为 2 时，两个基团 (Dye-X) 可以相同或不同： 其中 A 代表卤素原子、-OR¹ 或 -SR¹（其中 R¹ 代表烷基、芳基或杂环基）； B 代表具有不小于 0.3;C 代表化学键、氢原子、烷基、环烷基、芳基、卤素原子、-OR⁴、-CONR⁴R⁵、-SO₂NR⁴R⁵、-N(R³)-COR₄或 -N(R³)-SO₂R₄（其中 R³、和 R⁵ 各代表一个氢原子或一个选自 R¹ 所定义的基团，或 R⁴ 和 R⁵ 可相互结合形成一个 5 元环或 6 元环）；E 代表化学键、氢原子、烷基、卤素原子、-OR⁴、-CONR⁴R⁵、-SO₂NR⁴R⁵、-N(R⁵)-COR⁴ 或 -N(R⁵)-SO₂R⁴（其中 R⁴ 和 R⁵ 的含义与上述定义相同）；G 代表羟基或其盐，或选自式 (T)、(U) 或 (V) 所代表的基团： 其中 R²¹ 和 R²²（可以相同或不同）各自代表烷基、环烷基、烯基、芳烷基、芳基、杂环基、烷硫基、芳硫基、烷氧基、芳氧基或氨基，或 R²¹ 和 R²² 可相互结合形成 5 元环或 6 元环。