4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid | 890840-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)-benzoic acid
• 英文别名: 4-[5-(3-Pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]benzoic acid；4-(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
• CAS: 890840-30-9
• 化学式: C₁₉H₁₃N₃O₂
• 分子量: 315.331
• InChiKey: MVOZJKZFTAQTMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 1H-Pyrrolo[2,3-B]Pyridnes
  申请人：Frazee James S.

  公开号：US20090233955A1

  公开（公告）日：2009-09-17

  Derivatives of pyrrolo[2,3-b]pyridine which are useful as SGK-1 kinase inhibitors are described herein. The invention described herein also describes pharmaceutical compositions containing derivatives of pyrrolo[2,3-b]pyridine and methods of using pyrrolo[2,3-b]pyridine derivatives and pharmaceutical compositions thereof in the treatment of diseases mediated by SGK-1.

  本文描述了用作SGK-1激酶抑制剂的吡咯并[2,3-b]吡啶衍生物。本发明还描述了含有吡咯并[2,3-b]吡啶衍生物的制药组合物以及使用吡咯并[2,3-b]吡啶衍生物和其制药组合物治疗由SGK-1介导的疾病的方法。
• 1H-Pyrrolo[2,3-B]Pyridines
  申请人：Frazee James S.

  公开号：US20120238588A1

  公开（公告）日：2012-09-20

  Derivatives of pyrrolo[2,3-b]pyridine which are useful as SGK-1 kinase inhibitors are described herein. The invention described herein also describes pharmaceutical compositions containing derivatives of pyrrolo[2,3-b]pyridine and methods of using pyrrolo[2,3-b]pyridine derivatives and pharmaceutical compositions thereof in the treatment of diseases mediated by SGK-1.

  本文描述了作为SGK-1激酶抑制剂有用的吡咯[2,3-b]吡啶衍生物。本发明还描述了含有吡咯[2,3-b]吡啶衍生物的制药组合物以及使用吡咯[2,3-b]吡啶衍生物和制药组合物治疗由SGK-1介导的疾病的方法。
• 1H-PYRROLO[2,3-BETA]PYRIDINES
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1828180A1

  公开（公告）日：2007-09-05
• [EN] 1H-PYRROLO[2,3-B]PYRIDINES<br/>[FR] 1H -PYRROLO[2,3-B]PYRIDINES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2006063167A1

  公开（公告）日：2006-06-15

  [EN] Derivatives of pyrrolo[2,3-b]pyridine which are useful as SGK-1 kinase inhibitors are described herein. The invention described herein also describes pharmaceutical compositions containing derivatives of pyrrolo[2,3-b]pyridine and methods of using pyrrolo[2,3-b]pyridine derivatives and pharmaceutical compositions thereof in the treatment of diseases mediated by SGK-1.
  [FR] L'invention concerne des dérivés de pyrrolo[2,3-b]pyridine utiles comme inhibiteurs de kinase SGK-1. Cette invention concerne également des compositions pharmaceutiques renfermant des dérivés de pyrrolo[2,3-b]pyridine et des méthodes d'utilisation de dérivés de pyrrolo[2,3-b]pyridine et de leurs compositions dans le traitement de maladies induites par SGK-1.
• [EN] USE OF INHIBITORS OF HOST KINASES FOR THE TREATMENT OF INFECTIOUS DISEASES<br/>[FR] UTILISATION D'INHIBITEURS DE KINASES HÔTES POUR TRAITER LES MALADIES INFECTIEUSES
  申请人：CENIX BIOSCIENCE GMBH

  公开号：WO2010049173A1

  公开（公告）日：2010-05-06

  The present invention relates to the use of inhibitors of host kinases for the production of a medicament for therapy of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.