MMV026020 | 890839-84-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: MMV026020
• 英文别名: 4-[5-[3-(Methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl]benzenepropanoic acid；3-[4-[5-(3-methylsulfonylphenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl]propanoic acid
• CAS: 890839-84-6
• 化学式: C₂₃H₂₀N₂O₄S
• 分子量: 420.489
• InChiKey: UXFYDSZRRLQYKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 1H-Pyrrolo[2,3-B]Pyridnes
  申请人：Frazee James S.

  公开号：US20090233955A1

  公开（公告）日：2009-09-17

  Derivatives of pyrrolo[2,3-b]pyridine which are useful as SGK-1 kinase inhibitors are described herein. The invention described herein also describes pharmaceutical compositions containing derivatives of pyrrolo[2,3-b]pyridine and methods of using pyrrolo[2,3-b]pyridine derivatives and pharmaceutical compositions thereof in the treatment of diseases mediated by SGK-1.

  本文描述了用作SGK-1激酶抑制剂的吡咯并[2,3-b]吡啶衍生物。本发明还描述了含有吡咯并[2,3-b]吡啶衍生物的制药组合物以及使用吡咯并[2,3-b]吡啶衍生物和其制药组合物治疗由SGK-1介导的疾病的方法。
• 1H-Pyrrolo[2,3-B]Pyridines
  申请人：Frazee James S.

  公开号：US20120238588A1

  公开（公告）日：2012-09-20

  Derivatives of pyrrolo[2,3-b]pyridine which are useful as SGK-1 kinase inhibitors are described herein. The invention described herein also describes pharmaceutical compositions containing derivatives of pyrrolo[2,3-b]pyridine and methods of using pyrrolo[2,3-b]pyridine derivatives and pharmaceutical compositions thereof in the treatment of diseases mediated by SGK-1.

  本文描述了作为SGK-1激酶抑制剂有用的吡咯[2,3-b]吡啶衍生物。本发明还描述了含有吡咯[2,3-b]吡啶衍生物的制药组合物以及使用吡咯[2,3-b]吡啶衍生物和制药组合物治疗由SGK-1介导的疾病的方法。
• [EN] USE OF INHIBITORS OF HOST KINASES FOR THE TREATMENT OF INFECTIOUS DISEASES<br/>[FR] UTILISATION D'INHIBITEURS DE KINASES HÔTES POUR TRAITER LES MALADIES INFECTIEUSES
  申请人：CENIX BIOSCIENCE GMBH

  公开号：WO2010049173A1

  公开（公告）日：2010-05-06

  The present invention relates to the use of inhibitors of host kinases for the production of a medicament for therapy of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular malaria.
• [EN] USE OF SGK1 INHIBITOR AS THERAPEUTIC AGENT FOR INFLAMMATORY NEUROLOGICAL DISEASES<br/>[FR] UTILISATION DE L'INHIBITEUR DE SGK1 EN TANT QU'AGENT THÉRAPEUTIQUE POUR MALADIES NEUROLOGIQUES INFLAMMATOIRES<br/>[KO] 염증성 신경 질환의 치료제로서 SGK1 저해제의 용도
  申请人：UNIV HANYANG IND UNIV COOP FOUND

  公开号：WO2021006707A1

  公开（公告）日：2021-01-14

  본 발명은 Sgk1 저해제를 유효성분으로 포함하는 염증성 신경 질환의 예방 또는 치료용 약학 조성물 및 이를 이용한 염증성 신경 질환의 치료 방법에 관한 것으로, Sgk1의 발현 저해를 통해 신경세포의 노화 감소, 신경염증의 감소, 글루타메이트의 흡수 증가, 신경세포의 기능성 및 생존성 증진, 및 α-synuclein의 응집 방지 효과를 나타낼 수 있으므로, Sgk1 저해제를 염증성 신경 질환의 치료제로서 유용하게 활용할 수 있다.