(R)-2-benzyloxycarbonylmethyl-4-hydroxy-2-cyclopenten-1-one | 943924-68-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-benzyloxycarbonylmethyl-4-hydroxy-2-cyclopenten-1-one
• 英文别名: (R)-2-benzoxycarbonylmethyl-4-hydroxy-2-cyclopenten-1-one；benzyl 2-[(3R)-3-hydroxy-5-oxocyclopenten-1-yl]acetate
• CAS: 943924-68-3
• 化学式: C₁₄H₁₄O₄
• 分子量: 246.263
• InChiKey: PVPBOPSWOJIXGQ-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-2-benzyloxycarbonylmethyl-4-acetyloxy-2-cyclopenten-1-one 、 苯甲醇 、 (R)-2-ethoxycarbonylmethyl-4-acetyloxy-2-cyclopenten-1-one 以 乙醇 为溶剂， 以The titled compound was obtained with high optical purity (3.4 g, 99% e.e.)的产率得到(R)-2-benzyloxycarbonylmethyl-4-hydroxy-2-cyclopenten-1-one
  参考文献：
  名称：

  Processes for the preparations of optically active cyclopentenones and cyclopentenones prepared therefrom

  摘要：

  本发明涉及一种制备(R)-1式光学活性环戊酮的新工艺，其可用于制备前列腺素及其类似物。该发明还涉及从该工艺中制备的新型环戊酮。

  公开号：

  US20070166809A1

文献信息

• Processes for the preparations of optically active cyclopentenones and cyclopentenones prepared therefrom
  申请人：Yeh Yu-Chih

  公开号：US20070166809A1

  公开（公告）日：2007-07-19

  The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.

  本发明涉及一种制备(R)-1式光学活性环戊酮的新工艺，其可用于制备前列腺素及其类似物。该发明还涉及从该工艺中制备的新型环戊酮。
• Process for the preparation of optically active cyclopentenones
  申请人：Chirogate International Inc.

  公开号：EP1811037A1

  公开（公告）日：2007-07-25

  The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.

  本发明涉及制备具有光学活性的式(R)-1环戊烯酮的新工艺，该工艺可用于制备前列腺素及其类似物。 本发明还涉及由该工艺制备的新型环戊烯酮。
• Optically active cyclopentenones for use in the peparation of prostaglandins
  申请人：Wei, Shih-Yi

  公开号：EP1811037B1

  公开（公告）日：2011-02-23
• US8546114B2
  申请人：——

  公开号：US8546114B2

  公开（公告）日：2013-10-01
• Processes for the preparation of optically active cyclopentenones and cyclopentenones prepared therefrom
  申请人：Yeh Yu-Chih

  公开号：US08546114B2

  公开（公告）日：2013-10-01

  The present invention relates to novel processes for preparing optically active Cyclopentenones of Formula (R)-1, which are useful for the preparation of Prostaglandins and analogs thereof. The invention also relates to novel Cyclopentenones prepared from the processes.

  本发明涉及制备式(R)-1的新型光学活性环戊酮的方法，该方法对于前列腺素及其类似物的制备是有用的。该发明还涉及从这些方法中制备的新型环戊酮。