1-amino-1-(4-methoxy-phenyl)-propan-2-ol | 212394-48-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-amino-1-(4-methoxy-phenyl)-propan-2-ol
• 英文别名: 1-Amino-1-(4-methoxyphenyl)propan-2-OL；1-amino-1-(4-methoxyphenyl)propan-2-ol
• CAS: 212394-48-4
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: ZBXPOHJSNYWSOE-UHFFFAOYSA-N

物化性质

• 熔点：
  84 °C
• 沸点：
  329.7±32.0 °C(Predicted)
• 密度：
  1.097±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-amino-1-(4-methoxy-phenyl)-propan-2-ol 在 氢碘酸 作用下， 生成 β-oxy-α-(4-oxy-phenyl)-propylamine
  参考文献：
  名称：

  Takeda; Kuroda, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1921, # 467, p. 4

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 作用下， 生成 1-amino-1-(4-methoxy-phenyl)-propan-2-ol
  参考文献：
  名称：

  Takeda; Kuroda, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1921, # 467, p. 4

  摘要：

  DOI：

文献信息

• Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines
  作者：Martin H. Bolli、Steven V. Ley

  DOI：10.1039/a803612h

  日期：——

  An efficient combinatorial access to β-hydroxyamines suitable for automation is achieved by the mild oxidation of alcohols to aldehydes by polymer supported perruthenate (PSP), the subsequent clean olefination of the obtained aldehydes by polymer supported Wittig reagents followed by the epoxidation of the olefins by dimethyldioxirane (DMDO), and the final aminolysis of the epoxides with various amines is described.

  通过聚合物负载高铼酸盐（PSP）将醇温和氧化为醛，随后使用聚合物负载的Wittig试剂对所得醛进行清洁的烯化反应，接着用二甲基二氧杂环丙烷（DMDO）对烯烃进行环氧化，最后用各种胺对环氧化物进行胺解反应，实现了一种适用于自动化的β-羟基胺的高效组合合成方法。
• Takeda; Kuroda, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1919, # 449, p. 561
  作者：Takeda、Kuroda

  DOI：——

  日期：——
• SUBSTITUTED PYRIMDINONE DERIVATIVES AND METHODS OF USE
  申请人：AMGEN INC.

  公开号：EP1656366A1

  公开（公告）日：2006-05-17
• [EN] SUBSTITUTED PYRIMDINONE DERIVATIVES AND METHODS OF USE<br/>[FR] DERIVES DE PYRIMDINONE SUBSTITUES ET LEURS PROCEDES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2005019202A1

  公开（公告）日：2005-03-03

  The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, 0 and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R1 is additionally substituted; and R2 is a substituted C1-6alkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
• Read; Reid, Journal of the Chemical Society, 1928, p. 1489
  作者：Read、Reid

  DOI：——

  日期：——