2,2'-methanediyl-bis-benz[d][1,3]oxazin-4-one | 101646-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 2,2'-methanediyl-bis-benz[d][1,3]oxazin-4-one
• 英文别名: 2,2'-Methandiyl-bis-benz[d][1,3]oxazin-4-on；2,2'-Methylenebis(3,1-benzoxazine-4-one)；2-[(4-oxo-3,1-benzoxazin-2-yl)methyl]-3,1-benzoxazin-4-one
• CAS: 101646-19-9
• 化学式: C₁₇H₁₀N₂O₄
• 分子量: 306.277
• InChiKey: RFLLHIZFIWJOIH-UHFFFAOYSA-N

物化性质

• 沸点：
  519.0±60.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2'-methanediyl-bis-benz[d][1,3]oxazin-4-one 、 furan-2,3,5(4H)-trione pyridine (1:1) 生成 N,N'-di-2-carboxyanilide of malonic acid
  参考文献：
  名称：

  Heller, Chemische Berichte, 1915, vol. 48, p. 1191

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N'-di-2-carboxyanilide of malonic acid 在 乙酸酐 作用下， 生成 2,2'-methanediyl-bis-benz[d][1,3]oxazin-4-one
  参考文献：
  名称：

  Heller, Chemische Berichte, 1915, vol. 48, p. 1191

  摘要：

  DOI：

文献信息

• Pharmaceutical compositions of
  申请人：Sawai Pharmaceutical Co., Ltd.

  公开号：US04755506A1

  公开（公告）日：1988-07-05

  Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond, R.sup.2 and R.sup.2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, and R.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R.sup.2 and R.sup.2 ' cannot be both hydrogen, and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.2 ' are both hydrogen, then R.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative other than methyl ester, are novel.

  一般式为：##STR1## 其中A和B均为氢，或者A和B中的一个是式为：##STR2## 的基团（G），另一个是R.sup.5基团，其中R.sup.1是取代的芳基或杂环基团，R.sup.4和R.sup.5均为氢或者一起形成单一的化学键，R.sup.2和R.sup.2'独立地为氢、卤素、硝基、低级烷基或低级烷氧基，R.sup.3和R.sup.3'独立地为羧基或其官能衍生物，但是当A和B均为氢时，R.sup.2和R.sup.2'不能同时为氢。其中，化合物（I'）中，当A和B中的一个是基团（G），另一个是R.sup.5基团，其中R.sup.4和R.sup.5一起形成单一的化学键，R.sup.1为非取代芳基，R.sup.2和R.sup.2'均为氢时，R.sup.3和R.sup.3'独立地为羧基或其官能衍生物（甲酯除外），是新的。该化合物及其药学上可接受的盐是透明质酸酶抑制剂，可用作抗过敏剂和抗溃疡剂。
• Pharmaceutical compositions of-2,2-1,1-[bis-2,2'-(3,1-benzoxazin-4-one)9
  申请人：Sawai Pharmaceutical Co., Ltd.

  公开号：US04822791A1

  公开（公告）日：1989-04-18

  This invention relates to pharmaceutical compositions of compounds of the general formula: ##STR1## wherein R.sup.1 is an aryl group or a substituted aryl group wherein the substituent is halogen, hydroxy, C.sub.(1-6) lower alkoxy, C.sub.(1-6) lower alkylenedioxy, halo C.sub.(1-6) lower alkyl, cyano, nitro, mono- or di-C.sub.(1-6) alkylamino or C.sub.(1-6) lower alkanoylamino; or a 5-membered or 6-membered C.sub.(1-6) alkyl substituted or unsubstituted heterocyclic group containing a heteroatom selected from oxygen, nitrogen, and sulfur, or a condensed heterocyclic group consisting of a heterocycle as defined above and a benzene nucleus, and R.sup.2 and R.sup.2' are, independently, hydrogen, halogen, nitro, C.sub.(1-6) lower alkyl or C.sub.(1-6) lower alkoxy. These compounds have been found to exhibit hyaluronidase inhibiting activity, anti-allergic activity and anti-ulcerous activity. The present invention further contemplates processes for the preparation of said compounds and their pharmaceutical compositions.

  本发明涉及一般式化合物的制药组合物：##STR1##其中R.sup.1是芳基或取代芳基，其中取代基是卤素，羟基，C.sub.(1-6)低烷氧基，C.sub.(1-6)低烷二氧基，卤代C.sub.(1-6)低烷基，氰基，硝基，单或双C.sub.(1-6)烷基氨基或C.sub.(1-6)低烷酰胺基；或含有氧，氮和硫的5-或6-成员C.sub.(1-6)烷基取代或未取代的杂环基，或由上述异环和苯环组成的紧缩杂环基，R.sup.2和R.sup.2'独立地是氢，卤素，硝基，C.sub.(1-6)低烷基或C.sub.(1-6)低烷氧基。已发现这些化合物表现出透明质酸酶抑制活性，抗过敏活性和抗溃疡活性。本发明还涉及制备所述化合物及其制药组合物的过程。
• [(1,3-dioxo-1,3-propanediyl)diimino)]bisbenzoic acid derivatives
  申请人：Sawai Pharmaceutical Co., Ltd.

  公开号：US04634777A1

  公开（公告）日：1987-01-06

  Compounds of the general formula: ##STR1## wherein A and B are both hydrogen, or one of A and B is a group (G) of the formula: ##STR2## and the other is a group R.sup.5 wherein R.sup.1 is an aryl group or a heterocyclic group, both of them being optionally substituted, and R.sup.4 and R.sup.5 are both hydrogen or together form a single chemical bond, R.sup.2 and R.sup.2 ' are independently hydrogen, halogen, nitro, lower alkyl or lower alkoxy, and R.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative, with the proviso that (a) when A and B are both hydrogen, then R.sup.2 and R.sup.2 ' cannot be both hydrogen, and, where applicable, pharmaceuticably acceptable salts thereof are hyaluronidase inhibitors, and useful as anti-allergic agent and anti-ulcerous agent. Among the compound (I'), those wherein when one of A and B is the group (G) and the other is the group R.sup.5 wherein R.sup.4 and R.sup.5 together form a single chemical bond, R.sup.1 is unsubstituted aryl and R.sup.2 and R.sup.2 ' are both hydrogen, then R.sup.3 and R.sup.3 ' are independently carboxy or its functional derivative other than methyl ester, are novel.

  通式为：##STR1## 其中A和B都是氢，或者A和B中的一个是公式（G）的基团：##STR2## 另一个是基团R.sup.5，其中R.sup.1是芳基或杂环基团，两者都可以选择性地取代，而R.sup.4和R.sup.5都是氢或者一起形成单一化学键，R.sup.2和R.sup.2'分别是氢、卤素、硝基、低烷基或低烷氧基，而R.sup.3和R.sup.3'分别是羧基或其功能衍生物，但有以下规定：（a）当A和B都是氢时，R.sup.2和R.sup.2'不能同时为氢，其中适用的药学上可接受的盐是透明质酸酶抑制剂，可用作抗过敏剂和抗溃疡剂。在化合物（I'）中，当A和B中的一个是基团（G）而另一个是基团R.sup.5，其中R.sup.4和R.sup.5一起形成单一化学键，R.sup.1是未取代的芳基，而R.sup.2和R.sup.2'都是氢时，R.sup.3和R.sup.3'分别是羧基或其功能衍生物，但不包括甲酯时，是新颖的。
• Process for producing aromatic polyesters having increased degrees of polymerization and moulded articles composed of these polyesters
  申请人：TEIJIN LIMITED

  公开号：EP0019061A1

  公开（公告）日：1980-11-26

  A process for producing an aromatic polyester having an increased degree of polymerization. The process comprises reacting a hydroxyl-terminated, substantially linear, fiber-forming aromatic polyester having an aromatic dicarboxylic acid as a main acid component at an elevated temperature with a bi-cyclic imino ester compound of formula (I) or formula (II). According to the process, the molecularchains of the aromatic polyester are bonded to each other by the terminal hydroxyl groups thereof to form rapidly the aromatic polyester having an increased degree of polymerization. I Bis-oxazolones 11 Bis-oxazinones e.g.

  一种生产聚合度提高的芳香族聚酯的工艺。该工艺包括在高温下使以芳香族二羧酸为主要酸组分的羟基封端、基本线性的芳香族聚酯与式 (I) 或式 (II) 的双环亚氨基酯化合物反应。根据该工艺，芳香族聚酯的分子链通过其末端羟基相互键合，从而快速形成聚合度提高的芳香族聚酯。 I 双噁唑酮 11 双噁唑酮，例如
• Flame-retardant resin composition and electric wire
  申请人：POLYPLASTICS CO. LTD.

  公开号：EP0320159A1

  公开（公告）日：1989-06-14

  The invention provides a flame-retardant resin composition characterised in that it comprises (A) an aromatic polyester prepared by condensation polymerization between (a) a component substantially comprising an aromatic dicarboxylic acid or an ester-­forming derivative thereof and (b) a component substantially comprising an aliphatic diol or an ester-­forming derivative thereof, (B) 0.1 to 30% by weight based on the total amount of the composition of a compound represented by the general formula (1) or (2) wherein X represents a halogen atom; Y₁ and Y₂ each represent a group selected from hydroxyl, carboxyl, glycidyl ester and glycidyl ether groups; Z is a monovalent or divalent organic group and n is an integer of 1 or more and (C) 0.1 to 30% by weight based on the total amount of the composition of a compound represented by the general formula (3): L₁-M-L₂      (3) wherein M is a divalent organic group L₁ and L₂ may be the same or different from each other and each represent a 3- to 8-membered cyclic reactive group selected from those having the general formulae (4) to (7): in which each of R₁, R₂ and R₃ represent a divalent organic group wherein a hydrogen atom directly bonded to the ring may be substituted with an alkyl and/or aryl group. The invention also includes electric wires coated therewith.

  本发明提供了一种阻燃树脂组合物，其特征在于该组合物包括 (A) 由以下组分缩合聚合制备的芳香族聚酯：(a) 主要由芳香族二羧酸或其酯类衍生物组成的组分；(b) 主要由脂肪族二元醇或其酯类衍生物组成的组分、 (B) 以组合物总重量为基准，0.1%至 30%由通式(1)或(2)代表的化合物 其中 X 代表卤素原子；Y₁ 和 Y₂ 各自代表选自羟基、羧基、缩水甘油酯和缩水甘油醚基团的基团；Z 是一价或二价有机基团，n 是 1 或 1 以上的整数，且 (C) 通式（3）所代表的化合物占组合物总量的 0.1%至 30%（以重量计）： L₁-M-L₂ (3) 其中 M 是二价有机基团 L₁ 和 L₂ 可以彼此相同或不同，各自代表从通式（4）至（7）中选出的 3 至 8 元环状活性基团： 其中 R₁、R₂ 和 R₃ 各自代表二价有机基团，其中与环直接结合的氢原子可被烷基和/或芳基取代。 本发明还包括涂有该物质的电线。