(E)-4-[2-(2,4-dichlorophenyl)ethenyl]morpholine | 431948-25-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-4-[2-(2,4-dichlorophenyl)ethenyl]morpholine
• 英文别名: 4-[(E)-2-(2,4-dichlorophenyl)ethenyl]morpholine
• CAS: 431948-25-3
• 化学式: C₁₂H₁₃Cl₂NO
• 分子量: 258.147
• InChiKey: GMNDRJWUOCPWJJ-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.47
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (E)-4-[2-(2,4-dichlorophenyl)ethenyl]morpholine 以 丙醇 、 苯 为溶剂， 反应 6.0h， 生成 2-[5-(2,4-dichlorophenyl)-4-methyl-6-morpholinopyridin-2-yl]-1-(4-methylpiperazin-1-yl)ethanone
  参考文献：
  名称：

  An effective contribution to functionalized pyridines synthesis by way of an unusual rearrangement of amidines

  摘要：

  A new synthesis of 2-pyridineacetamides was developed starting from pyran-2-one N-functionalized amidines 4. Secondary amines reacted in a sealed tube with amidines 4 and, by nucleophilic attack on pyran-2-one nucleus and thermal rearrangement, afforded exclusively the 2-pyridineacetamide derivatives 6 or a mixture of amide compounds 6 and 7 depending on the substituents linked to C-alpha of the starting amidine 4. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01197-8
• 作为产物：
  描述：

  吗啉 、 (2,4-二氯苯基)乙醛 以 甲苯 为溶剂， 生成 (E)-4-[2-(2,4-dichlorophenyl)ethenyl]morpholine
  参考文献：
  名称：

  An effective contribution to functionalized pyridines synthesis by way of an unusual rearrangement of amidines

  摘要：

  A new synthesis of 2-pyridineacetamides was developed starting from pyran-2-one N-functionalized amidines 4. Secondary amines reacted in a sealed tube with amidines 4 and, by nucleophilic attack on pyran-2-one nucleus and thermal rearrangement, afforded exclusively the 2-pyridineacetamide derivatives 6 or a mixture of amide compounds 6 and 7 depending on the substituents linked to C-alpha of the starting amidine 4. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01197-8

文献信息

• An effective contribution to functionalized pyridines synthesis by way of an unusual rearrangement of amidines
  作者：Egle M Beccalli、Alessandro Contini、Pasqualina Trimarco

  DOI：10.1016/s0040-4020(01)01197-8

  日期：2002.2

  A new synthesis of 2-pyridineacetamides was developed starting from pyran-2-one N-functionalized amidines 4. Secondary amines reacted in a sealed tube with amidines 4 and, by nucleophilic attack on pyran-2-one nucleus and thermal rearrangement, afforded exclusively the 2-pyridineacetamide derivatives 6 or a mixture of amide compounds 6 and 7 depending on the substituents linked to C-alpha of the starting amidine 4. (C) 2002 Elsevier Science Ltd. All rights reserved.