fluoren-1-ylmethyl-methyl ether | 139552-06-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: fluoren-1-ylmethyl-methyl ether
• 英文别名: Fluoren-1-ylmethyl-methyl-aether；1-Methoxymethyl-fluoren；1-methoxymethylfluorene；1-(methoxymethyl)-9H-fluorene
• CAS: 139552-06-0
• 化学式: C₁₅H₁₄O
• 分子量: 210.276
• InChiKey: XZKPFRIEWDWYDH-UHFFFAOYSA-N

物化性质

• 熔点：
  58 °C
• 沸点：
  327.9±11.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  fluoren-1-ylmethyl-methyl ether 在 正丁基锂 、 CO₂ 作用下， 以 四氢呋喃 为溶剂， 以33.1%的产率得到9H-芴-9-羧酸,1-(甲氧基甲基)-
  参考文献：
  名称：

  Method for treating inflammation and compounds and compositions suitable

  摘要：

  本发明涉及一种治疗炎症病症的方法，以及适用于该方法的化合物和组合物，这些化合物具有以下结构式：##STR1##其中：X为亚甲基，乙烯基，乙烯氧基或氧原子；Q为##STR2##其中C'是脂溶性氨基酸的残基，Y为--CO₂H，--CH₂OH，--CONR₁R₂或--CO₂R₁，其中R₁和R₂为氢、烷基或芳基；R₃和R₄独立地为氢、烷基或芳基；A和B独立地为氢、融合苯环、烷基、芳基、烷基芳基、芳基烷基、烷氧基、烷氧基烷基、卤素或硝基；或其药学上可接受的盐。

  公开号：

  US05079260A1
• 作为产物：
  描述：

  1-甲基巯基甲基芴 在 盐酸 作用下， 生成 fluoren-1-ylmethyl-methyl ether
  参考文献：
  名称：

  Molecular Rearrangement of Fluorylidene Dimethyl Sulfide to Fluorene-1-dimethyl Sulfide¹

  摘要：

  DOI：

  10.1021/ja01209a011

文献信息

• [EN] PROCESS FOR THE DI-O-ALKYLATION OF 1,3-DIOLS TO 1,3-DIETHERS<br/>[FR] PROCÉDÉ DE DI-O-ALKYLATION DE 1,3-DIOLS EN 1,3-DIÉTHERS
  申请人：SABIC GLOBAL TECHNOLOGIES BV

  公开号：WO2021004760A1

  公开（公告）日：2021-01-14

  The present invention relates to a process for the di-O-alkylation of a 1,3-diol according to Formula I (I), said process comprising reacting said 1,3-diol with dioxane, an aliphatic or aromatic hydrocarbon solvent, an alkali metal hydroxide, and dimethyl sulphate, in order to obtain a 1,3-diether according to Formula II (II), wherein R1 and R2 are each independently a hydrogen atom or a hydrocarbyl group selected from alkyl, alkenyl, aryl, aralkyl, or alkylaryl groups, and one or more combinations thereof. The process according to the invention is an improved process for preparing 1,3-diether, such as 9,9-bis(methoxymethyl)fluorene, in a high yield and/or having a high purity. 9,9-bis(methoxymethyl)fluorene is a compound that is used as an electron donor for Ziegler-Natta catalysts.

  本发明涉及一种根据式I（I）进行1,3-二醇的二-O-烷基化的方法，所述方法包括将所述1,3-二醇与二噁烷、脂肪族或芳香烃溶剂、碱金属氢氧化物和硫酸二甲酯反应，以获得根据式II（II）的1,3-二醚，其中R1和R2分别独立地是氢原子或从烷基、烯基、芳基、芳基烷基或烷基芳基组中选择的烃基团，以及一个或多个组合。根据本发明的方法是一种改进的制备1,3-二醚的方法，例如9,9-双（甲氧甲基）芴，其产率高和/或纯度高。9,9-双（甲氧甲基）芴是一种用作Ziegler-Natta催化剂的电子给体的化合物。
• [EN] PROCESS FOR THE RESOLUTION OF (R,S)-DIAZEPANE AND DIAZEPANONE DERIVATIVES<br/>[FR] PROCÉDÉ POUR LA RÉSOLUTION DE DÉRIVÉS (R,S)-DIAZÉPANE ET DIAZÉPANONE
  申请人：SANDOZ AG

  公开号：WO2016020404A1

  公开（公告）日：2016-02-11

  The present invention relates to a process for the preparation of an acid salt (T) of a compound of formula (A) (A) as well as to the acid salt (T) and the compound (A) as such,wherein R1 is selected from the group consisting of H, PG1 and RA, with RA being or and wherein PG1 is a suitable protecting group, and wherein n is 0 or 1, wherein the acid salt (T) is the salt of one stereoisomer of a chiral acid, preferably wherein the chiral acid salt is a tartaric acid derivative salt, preferably wherein the tartaric acid derivative salt is selected from the group consisting of 2,3-ditoluoyl tartaric acid salt, 2,3-dibenzoyl tartaric acid salt, 2,3-dianisoyl tartaric acid salt, 2,3-dibenzoyl tartaric acid mono(dimethylamide) salt and a mixture of two or more thereof. Further the present invention relates to use of (T) and/or (A) for the preparation of suvorexant.

  本发明涉及一种用于制备化合物(A)的酸盐(T)的过程，化合物(A)的化学式如下，其中R1选择自H、PG1和RA组成的群，RA为或，PG1为适当的保护基，n为0或1，其中酸盐(T)是手性酸的立体异构体的盐，优选的是手性酸盐是酒石酸衍生物盐，优选的是酒石酸衍生物盐选择自2,3-二甲苯基酰基酒石酸盐，2,3-二苯甲酰基酒石酸盐，2,3-二苯甲酰基酒石酸盐，2,3-二苯甲酰基酒石酸单(二甲酰胺)盐以及两者或两者以上的混合物。此外，本发明还涉及(T)和/或(A)用于制备苏沃瑞昔。
• [EN] CATALYST SYSTEM FOR POLYMERISATION OF AN OLEFIN<br/>[FR] SYSTÈME CATALYSEUR POUR LA POLYMÉRISATION D'UNE OLÉFINE
  申请人：SAUDI BASIC IND CORP

  公开号：WO2015022298A1

  公开（公告）日：2015-02-19

  The present invention relates to a catalyst system comprising a procatalyst, a co-catalyst and an external electron donor, wherein the external electron donor comprises a compound having the structure according to Formula I: Si (L)n (OR11)4-n (Formula I), wherein, Si is a silicon atom with valency 4+; O is an oxygen atom with valency 2- and O is bonded to Si via the silicon-oxygen bond; n is 1, 2, 3 or 4; R11 is a selected from the group consisting of linear, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms; L is a group represented by (Formula II), wherein, L is bonded to the silicon atom via the nitrogen-silicon bond; L has a single substituent on the nitrogen atom, where this single substituent is an imine carbon atom; and X and Y are independently selected from the group consisting of a hydrogen atom; a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements; a linear, branched and cyclic alkyl having at most 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements and an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 7 of the IUPAC Periodic Table of the Elements.

  本发明涉及一种催化剂体系，包括原催化剂、协同催化剂和外部电子供体，其中外部电子供体包括具有以下结构的化合物：Si（L）n（OR11）4-n（式I），其中，Si是具有4价的硅原子；O是具有2价的氧原子，通过硅氧键与Si相连；n为1、2、3或4；R11选自具有最多20个碳原子的线性、支链和环烷基以及具有6至20个碳原子的芳香族取代和未取代的烃基；L是由（式II）表示的一组，其中，L通过氮硅键与硅原子相连；L在氮原子上具有单个取代基，该单个取代基为亚胺碳原子；X和Y分别选自IUPAC元素周期表的13、14、15、16或17族的杂原子、最多含有20个碳原子的线性、支链和环烷基，可以包含来自IUPAC元素周期表的13、14、15、16或17族的杂原子，以及具有6至20个碳原子的芳香族取代和未取代的烃基，可以包含来自IUPAC元素周期表的13、14、15、16或17族的杂原子。
• CATALYST SYSTEM FOR POLYMERISATION OF AN OLEFIN
  申请人：ZUIDEVELD Martin Alexander

  公开号：US20160176998A1

  公开（公告）日：2016-06-23

  The present invention relates to a catalyst system comprising a procatalyst, a co-catalyst and an external electron donor, wherein the external electron donor comprises a compound having the structure according to Formula I: Si(L) n (OR 11 ) 4-n (Formula I), wherein, Si is a silicon atom with valency 4+; O is an oxygen atom with valency 2− and O is bonded to Si via the silicon-oxygen bond; n is 1, 2, 3 or 4; R 11 is a selected from the group consisting of linear, branched and cyclic alkyl having at most 20 carbon atoms and aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms; L is a group represented by (Formula II), wherein, L is bonded to the silicon atom via the nitrogen-silicon bond; L has a single substituent on the nitrogen atom, where this single substituent is an imine carbon atom; and X and Y are independently selected from the group consisting of a hydrogen atom; a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements; a linear, branched and cyclic alkyl having at most 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 17 of the IUPAC Periodic Table of the Elements and an aromatic substituted and unsubstituted hydrocarbyl having 6 to 20 carbon atoms, optionally containing a heteroatom selected from group 13, 14, 15, 16 or 7 of the IUPAC Periodic Table of the Elements.

  本发明涉及一种催化剂体系，包括原催化剂、协同催化剂和外部电子给体，其中，外部电子给体包括具有以下结构的化合物，即式I：Si（L）n（OR11）4-n（式I），其中，Si是价态为4+的硅原子；O是价态为2-的氧原子，通过硅氧键与Si相连；n为1、2、3或4；R11是从线性、支链和环烷烃中选择的，其最多含有20个碳原子，并且是芳香取代和未取代的烃基，其碳原子数为6至20个；L是由式II表示的基团，其中，L通过氮硅键与硅原子连接；L在氮原子上有一个单取代基团，该单取代基团是亚胺碳原子；X和Y独立地选择自元素周期表中第13、14、15、16或17族的杂原子、最多含有20个碳原子的线性、支链和环烷烃，可选含有元素周期表中第13、14、15、16或17族的杂原子和含有6至20个碳原子的芳香取代和未取代的烃基，可选含有元素周期表中第13、14、15、16或17族的杂原子。
• Transparent elastomeric thermoplastic polyolefin compositions
  申请人：Basell Technology Company B.V.

  公开号：EP1176169A1

  公开（公告）日：2002-01-30

  An elastomeric thermoplastic polyolefin composition comprising (I) a crystalline propylene polymer containing at least 80% by weight of a fraction insoluble in xylene at room temperature, the intrinsic viscosity being higher than 0.5 dL/g; (II) an atactic or amorphous propylene polymer having intrinsic viscosity higher than 0.5 dL/g; and (III) an elastomeric olefin polymer consisting of copolymers of ethylene with a comonomer selected from a C3-C8 α-olefin, the intrinsic viscosity ranging from 1 to 4 dL/g. In said polyolefin composition the density of the elastomeric olefin polymer (deOP) satisfies the following relation:deOP±0.005=dcPP × [wcPP/(wcPP + waPP)] } + daPP × [waPP/(wcPP+ waPP)]} wherein wcPP and waPP are the weight percentage content of components (I) and (II) respectively and dcPP and daPP are the density at room temperature of components (I) and (II) respectively.

  一种弹性热塑性聚烯烃组合物，包括(I)一种结晶丙烯聚合物，其中含有至少80%（重量）在室温下不溶于二甲苯的部分，其固有粘度高于0.5 dL/g；(II) 无规或无定形丙烯聚合物，其固有粘度高于 0.5 dL/g；以及 (III) 弹性烯烃聚合物，由乙烯与选自 C3-C8 α-烯烃的共聚单体组成，其固有粘度为 1 至 4 dL/g。在所述聚烯烃组合物中，弹性烯烃聚合物的密度（deOP）满足以下关系式：deOP±0.005=dcPP × [wcPP/(wcPP + waPP)] } + daPP × [waPP/(wcPP + waPP)] }。+daPP×[waPP/(wcPP+waPP)]}，其中 wcPP 和 waPP 分别是成分 (I) 和 (II) 的重量百分比含量，dcPP 和 daPP 分别是成分 (I) 和 (II) 在室温下的密度。