3-(4-甲基苯基)吡咯烷盐酸盐 | 899425-95-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 3-(4-甲基苯基)吡咯烷盐酸盐
• 中文别名: 3-(4-甲苯基)吡咯烷
• 英文名称: 3-(4-Methylphenyl)pyrrolidine
• CAS: 899425-95-7
• 化学式: C₁₁H₁₅N
• mdl: MFCD11047386
• 分子量: 161.24
• InChiKey: ZHJRWNCIVYOGSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] COMPOSITION AND METHODS OF USE OF SMALL MOLECULES AS BINDING LIGANDS FOR THE MODULATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9(PCSK9) PROTEIN ACTIVITY<br/>[FR] COMPOSITION ET PROCÉDÉS D'UTILISATION DE PETITES MOLÉCULES EN TANT QUE LIGANDS DE LIAISON POUR LA MODULATION DE L'ACTIVITÉ PROPROTÉINE CONVERTASE SUBTILISINE/PROTÉINE KEXINE DE TYPE 9 (PCSK9)
  申请人：SRX CARDIO LLC

  公开号：WO2016029037A1

  公开（公告）日：2016-02-25

  This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small molecule compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small molecule ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small molecule ligands that can raise LDL levels.

  这项发明涉及PCSK9生物学领域，以及用于调节PCSK9生物活性的小分子配体的组成和使用方法。具体而言，该发明提供了调节低密度脂蛋白循环水平的小分子化合物组合物，通过改变蛋白质PCSK9的构象来实现。将这些小分子配体与PCSK9结合会改变蛋白质的构象，修改PCSK9与内源性低密度脂蛋白受体之间的相互作用，并可能导致循环LDL胆固醇水平降低或增加。高LDL胆固醇水平与心脏疾病风险增加相关。低LDL胆固醇水平在其他情况下可能会有问题，比如肝功能障碍；因此，开发能够提高LDL水平的小分子配体也具有实用性。
• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：PAKINAX PTY LTD

  公开号：WO2022000031A1

  公开（公告）日：2022-01-06

  Described herein are compounds that are inhibitors of p21-activated kinases (PAKS). In particular, the compounds described herein are demonstrated to be selective PAK4 inhibitors. The compounds described herein are also demonstrated to reduce the expression of key immune checkpoint molecules, such as PD-1 and CHEK2. Also described herein are pharmaceutical compositions containing such compounds, methods for using such compounds in the treatment of cancers, more specifically, the treatment of pancreatic and lung cancers, and to related uses.

  本文描述了一些抑制p21激活激酶（PAKS）的化合物。特别地，本文描述的化合物被证明是选择性PAK4抑制剂。本文描述的化合物还被证明可以减少关键的免疫检查点分子的表达，例如PD-1和CHEK2。本文还描述了含有这些化合物的药物组合物，使用这些化合物治疗癌症的方法，更具体地说，治疗胰腺和肺癌，以及相关用途。
• Methods and compositions for the treatment of neuropathies and related disorders
  申请人：Lippa S. Arnold

  公开号：US20070082939A1

  公开（公告）日：2007-04-12

  The present invention provides novel compositions and methods for treating symptoms associated with neuropathic disorders such as hyperalgesia, allodynia, and parasthesias, using a 1-aryl-3-azabicyclo[3.1.0] hexane. The invention further relates to the use of 1-aryl-3-azabicyclo[3.1.0] hexanes in pharmaceutical compositions and methods for treating neuropathic disorders and related symptoms in mammals. Patients amenable to treatment according to the invention include those suffering from diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia, chronic lower back pain, sciatica, idiopathic and post-traumatic neuropathies, HIV-associated neuropathic pain, among many other neuropathic disorders and related symptoms.

  本发明提供了一种新型组合物和方法，用于治疗与神经病理性疾病相关的症状，如过度疼痛、触痛和感觉异常，使用1-芳基-3-氮杂双环[3.1.0]己烷。本发明还涉及在制药组合物中使用1-芳基-3-氮杂双环[3.1.0]己烷以及治疗哺乳动物神经病理性疾病和相关症状的方法。根据本发明可治疗的患者包括患有糖尿病神经病变、带状疱疹后遗神经痛、三叉神经痛、慢性腰痛、坐骨神经痛、特发性和创伤后神经病变、HIV相关神经病理性疼痛等许多神经病理性疾病和相关症状的患者。
• Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(PCSK9) protein activity
  申请人：SRX CARDIO, LLC

  公开号：US10034892B2

  公开（公告）日：2018-07-31

  This invention is related to the field of PCSK9 biology and the composition and methods of use of small molecule ligands for modulation of PCSK9 biological activity. In particular, the invention provides compositions of small molecule compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9. Binding these small molecule ligands to PCSK9 alters the conformation of the protein, modifying the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for small molecule ligands that can raise LDL levels.

  本发明涉及 PCSK9 生物学领域以及用于调节 PCSK9 生物活性的小分子配体的组成和使用方法。特别是，本发明提供了通过改变蛋白质 PCSK9 的构象来调节循环中低密度脂蛋白水平的小分子化合物组合物。将这些小分子配体与 PCSK9 结合可改变该蛋白的构象，改变 PCSK9 与内源性低密度脂蛋白受体之间的相互作用，并可导致循环中低密度脂蛋白胆固醇水平的降低或升高。低密度脂蛋白胆固醇水平高与心脏病风险增加有关。低密度脂蛋白胆固醇水平过低可能会对肝功能障碍等其他疾病造成困扰；因此，能提高低密度脂蛋白水平的小分子配体也很有用。
• Thermoplastic resin composition
  申请人：NIPPON NYUKAZAI CO., LTD.

  公开号：US10113049B2

  公开（公告）日：2018-10-30

  [Problem] Provided is a thermoplastic resin composition excellent in weather resistance. [Solution] A thermoplastic resin composition containing (a) a thermoplastic resin and (b) an ionically bonded salt represented by the following Chemical Formula (1) or (2): in the Chemical Formulae (1) and (2) above, R1 and R2 each independently represent a substituted or unsubstituted linear, branched, or cyclic alkyl group having from 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having from 6 to 30 carbon atoms, or a substituted or unsubstituted arylalkyl group having from 7 to 31 carbon atoms, A is a linear or branched alkylene group having from 2 to 4 carbon atoms, n represents an integer of 0 to 50, Q1 and Q2 each independently represent at least one kind selected from the group consisting of an ammonium ion, an imidazolium ion, a pyridinium ion, a pyrrolidinium ion, a pyrrolinium ion, a piperidinium ion, a pyrazinium ion, a pyrimidinium ion, a triazolium ion, a triazinium ion, a quinolinium ion, an isoquinolinium ion, an indolinium ion, a quinoxalinium ion, a piperazinium ion, an oxazolinium ion, a thiazolinium ion, and a morpholinium ion.

  [问题]提供一种耐候性优异的热塑性树脂组合物。 [解决方案] 一种热塑性树脂组合物，含有 (a) 热塑性树脂和 (b) 由以下化学式（1）或（2）表示的离子键盐： 在上述化学式（1）和（2）中，R1 和 R2 各自独立地代表具有 1 至 30 个碳原子的取代或 未取代的直链、支链或环状烷基、具有 6 至 30 个碳原子的取代或未取代的芳基或具有 7 至 31 个碳原子的取代或未取代的芳烷基，A 是具有 2 至 4 个碳原子的直链或支链亚烷基，n 代表 0 至 50 的整数、Q1 和 Q2 各自独立地代表至少一种选自以下组成的组的物质：铵离子、咪唑鎓离子、吡啶鎓离子、吡咯烷鎓离子、吡咯烷鎓离子、哌啶鎓离子、吡嗪鎓离子嘧啶鎓离子、三唑鎓离子、三嗪鎓离子、喹啉鎓离子、异喹啉鎓离子、吲哚鎓离子、喹喔啉鎓离子、哌嗪鎓离子、噁唑啉鎓离子、噻唑啉鎓离子和吗啉鎓离子。