diisopropyl-maleic acid anhydride | 35068-24-7

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: diisopropyl-maleic acid anhydride
• 英文别名: 2,3-diisopropylmaleic anhydride；Diisopropylmaleinsaeureanhydrid；3,4-Diisopropylfuran-2,5-dione；3,4-di(propan-2-yl)furan-2,5-dione
• CAS: 35068-24-7
• 化学式: C₁₀H₁₄O₃
• 分子量: 182.219
• InChiKey: CDKIJDCCEJTBLH-UHFFFAOYSA-N

物化性质

• 沸点：
  266.1±9.0 °C(Predicted)
• 密度：
  1.096±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  diisopropyl-maleic acid anhydride 在 水 作用下， 生成 Diisopropylmaleinsaeure
  参考文献：
  名称：

  Cyclic anhydrides. III. Equilibrium constants for the acid-anhydride equilibrium in aqueous solutions of certain vicinal diacids

  摘要：

  DOI：

  10.1021/ja00751a040
• 作为产物：
  描述：

  2,3-diisopropylsuccinic acid 生成 diisopropyl-maleic acid anhydride
  参考文献：
  名称：

  Cyclic anhydrides. III. Equilibrium constants for the acid-anhydride equilibrium in aqueous solutions of certain vicinal diacids

  摘要：

  DOI：

  10.1021/ja00751a040

文献信息

• Metallo-beta-lactamase inhibitors
  申请人：Chikauchi Ken

  公开号：US20080090825A1

  公开（公告）日：2008-04-17

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  一种新的金属β-内酰胺酶抑制剂，作为一种药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-BETA-LACTAMASE INHIBITORS
  申请人：Chikauchi Ken

  公开号：US20120071457A1

  公开（公告）日：2012-03-22

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明揭示了一种新型金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。将通式（I）化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-B-LACTAMASE INHIBITORS
  申请人：MEIJI SEIKA KAISHA, LTD.

  公开号：US20160151322A1

  公开（公告）日：2016-06-02

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式(I)的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式(I)的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• Terminal-modified imide oligomer and solution composition of the same
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0304913A2

  公开（公告）日：1989-03-01

  A terminal-modified imide oligomer having an unsatu­rated group as a terminal group and an imide bond inside of the oligomer which is produced by reacting 2,3,3′,4′-­or 3,3′,4,4′-biphenyltetracarboxylic acid or its deriva­tive, a diamine compound, and an unsaturated dicarboxylic acid or its derivative and/or an unsaturated monoamine in an organic solvent is disclosed. This oligomer has a logarithmic viscosity of not more than 1.0. This logari­thmic viscosity is measured under the conditions of con­centration of 0.5 g/100 mℓ-solvent (N-methyl-2-pyrroli­done) and a temperature of 30°C, and has a melting point of 50 to 300°C.

  本发明公开了一种末端改性的酰亚胺低聚物，它具有一个不饱和基团作为末端基团，低聚物内部有一个酰亚胺键，该低聚物是由 2,3,3′,4′ 或 3,3′,4,4′- 联苯四羧酸或其衍生物、二胺化合物和不饱和二羧酸或其衍生物和/或不饱和单胺在有机溶剂中反应生成的。这种低聚物的对数粘度不超过 1.0。该对数粘度是在浓度为 0.5 g/100 mℓ 溶剂（N-甲基-2-吡咯烷酮）和温度为 30°C 的条件下测得的，熔点为 50 至 300°C。
• Terminal-modified imide oligomer composition
  申请人：UBE INDUSTRIES, LTD.

  公开号：EP0395020A2

  公开（公告）日：1990-10-31

  A composition of terminal-modified imide oligomers is disclosed. The composition comprises a flexible terminal-­modified imide oligomer (A) and a rigid terminal-modified imide oligomer (B). The flexible terminal-modified imide oligomer (A) is selected from specific oligomers (I) and (II). The rigid terminal-modified imide oligomer (B) is selected from specific oligomers (III) and (IV). The oligomer (I) is formed from biphenyltetracarboxylic acid or its derivative, an aromatic diamine compound (a) and an un­saturated monoamine compound or an unsaturated carboxylic acid or its derivative. The oligomer (II) is formed from biphenyltetracarboxylic acid or its derivative and an un­saturated monoamine compound. The oligomer (III) is formed from biphenyltetracarboxylic acid or its derivative, an aromatic diamine compound (b) and an unsaturated monoamine compound or an unsaturated carboxylic acid or its deriva­tive. The oligomer (IV) is formed from pyromellitic acid or its derivative, an aromatic diamine compound (c) and an unsaturated monoamine compound or an unsaturated carboxylic acid or its derivative. The aromatic diamine compound (a) has two or more aromatic rings which are combined with each other directly or by a divalent group consisting of one, two or three atoms. The aromatic diamine compound (b) has only one aromatic ring or condensed ring. The aromatic di­amine compound (c) may have two or more aromatic rings as is defined in the compound (a), or may have only one aro­matic ring or condensed ring as is defined in the compound (b).

  本发明公开了一种端基改性亚胺低聚物组合物。该组合物包括柔性末端改性亚胺低聚物（A）和刚性末端改性亚胺低聚物（B）。柔性末端改性亚胺低聚物（A）选自特定的低聚物（I）和（II）。刚性末端改性亚胺低聚物（B）选自特定低聚物（III）和（IV）。低聚物(I)由联苯四羧酸或其衍生物、芳香族二胺化合物(a)和不饱和一元胺化合物或不饱和羧酸或其衍生物形成。低聚物（II）由联苯四羧酸或其衍生物和不饱和一元胺化合物形成。低聚物（III）由联苯四羧酸或其衍生物、芳香族二胺化合物（b）和不饱和一元胺化合物或不饱和羧酸或其衍生物形成。低聚物(IV)由吡咯烷酮酸或其衍生物、芳香族二胺化合物(c)和不饱和一元胺化合物或不饱和羧酸或其衍生物形成。芳香族二胺化合物（a）具有两个或两个以上的芳香环，这些芳香环直接或通过由一个、 两个或三个原子组成的二价基团相互结合。芳香族二胺化合物（b）只有一个芳香环或缩合环。芳香族二胺化合物（c）可以有两个或两个以上的芳香环，如化合物（a）中所定义的，也可以只有一个芳香环或缩合环，如化合物（b）中所定义的。