3,3'-dichloro-4,4'-dimethoxy-biphenyl | 64578-16-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-dichloro-4,4'-dimethoxy-biphenyl
• 英文别名: 3,3'-Dichlor-4,4'-dimethoxy-biphenyl；3,3'-Dichlor-4,4'-dimethoxybiphenyl；2-Chloro-4-(3-chloro-4-methoxyphenyl)-1-methoxybenzene
• CAS: 64578-16-1
• 化学式: C₁₄H₁₂Cl₂O₂
• 分子量: 283.154
• InChiKey: DLYGUNPYROGYQJ-UHFFFAOYSA-N

物化性质

• 熔点：
  156-158 °C(Solv: ethanol (64-17-5))
• 沸点：
  392.3±42.0 °C(Predicted)
• 密度：
  1.249±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,4'-Dihydroxy-3,3'-dichlorobiphenyl 生成 3,3'-dichloro-4,4'-dimethoxy-biphenyl
  参考文献：
  名称：

  酚醚和苯甲酸酯的卤化。第十六部分。二苯甲醚和萘醚的氯化动力学

  摘要：

  DOI：

  10.1039/jr9540001775

文献信息

• Mucochloric Acid: A Useful Synthon for the Selective Synthesis of 4-Aryl-3-chloro-2(5H)-furanones, (Z)-4-Aryl-5-[1-(aryl)methylidene]-3-chloro-2(5H)-furanones and 3,4-Diaryl-2(5H)-furanones
  作者：Fabio Bellina、Chiara Anselmi、Francesca Martina、Renzo Rossi

  DOI：10.1002/ejoc.200300097

  日期：2003.6

  4-Dichloro-2(5H)-furanone, which has been prepared efficiently from mucochloric acid, has been transformed selectively into 4-aryl-3-chloro-2(5H)-furanones either by Suzuki- or Stille-type reactions. These monochloro derivatives have been used as precursors either to (Z)-4-aryl-5-[1-(aryl)methylidene]-3-chloro-2(5H)-furanones, including naturally occurring rubrolide M, or to unsymmetrical 3,4-diaryl-2(5H)-furanones

  由粘氯酸有效制备的3,4-二氯-2（5 H）-呋喃酮已通过Suzuki-或Stille-选择性地转化为4-芳基-3-氯-2（5 H）-呋喃酮类型反应。这些一氯衍生物已被用作（Z）-4-芳基-5- [1-（芳基）亚甲基] -3-氯-2（5 H）-呋喃酮的前体，包括天然存在的罗布洛尔M，或不对称的前体。 3，4-二芳基-2（5 H）-呋喃酮。约2（5 H已经发现，如此制备的呋喃酮衍生物在体外对NCI三细胞系面板表现出显着的细胞毒性活性，但是对NCI人肿瘤60细胞系面板的细胞毒性有限。（©Wiley-VCH Verlag GmbH＆Co.KGaA，69451 Weinheim，Germany，2003）
• Total synthesis of rubrolide M and some of its unnatural congeners
  作者：Fabio Bellina、Chiara Anselmi、Renzo Rossi

  DOI：10.1016/s0040-4039(02)00202-2

  日期：2002.3

  Two protocols have been developed for the Pd-catalyzed regioselective synthesis of 4-aryl-3-chloro-2(5H)-furanones starting from 3,4-dichloro-2(5H)-furanone. These monochloro derivatives have then been used as precursors to (Z)-4-aryl-5-[1-(aryl)methylidene]-3-chloro-2(5H)-furanones including naturally-occurring rubrolide M.

  已经开发了用于从3,4-二氯-2（5 H）-呋喃酮开始Pd催化的4-芳基-3-氯2（5 H）-呋喃酮的区域选择性合成的两种方案。这些一氯衍生物随后被用作（Z）-4-芳基-5- [1-（芳基）亚甲基] -3-氯-2（5 H）-呋喃酮的前体，包括天然存在的罗布洛尔M。
• Regioselective halogenation of biphenyls for preparation of valuable polyhydroxylated biphenyls and diquinones
  作者：Paolo Bovicelli、Roberto Antonioletti、Antonella Onori、Giovanna Delogu、Davide Fabbri、Maria Antonietta Dettori

  DOI：10.1016/j.tet.2005.10.009

  日期：2006.1

  Electron-rich biphenyls were selectively oxyfunctionalised through a halogenation-methoxylation sequence. The obtained biphenyl methyl ethers were then oxidised to the corresponding quinones. This strategy transforms commercially available biphenyls into both natural and bioactive oxidised compounds. (c) 2005 Elsevier Ltd. All rights reserved.
• Polymer Electrolyte, Membrane/Electrode Assembly, and Fuel Cell
  申请人：Itou Takayuki

  公开号：US20070231652A1

  公开（公告）日：2007-10-04

  A polymer electrolyte having a repetitive structure represented by the following formula (1): wherein B represents a single bond or a bivalent group, A represents a bivalent aromatic group, Y represents —SO 2 —, —SO— or —CO—, R 1 represents a substituent, n1 represents an integer of from 0 to 3, L represents a perfluoroalkylene group, and M represents an ionic group.
• US7947406B2
  申请人：——

  公开号：US7947406B2

  公开（公告）日：2011-05-24