7-chloro-N-[2-(ethylamino)ethyl]-2-hydroxy-4-oxopyrido[1,2-a]pyrimidine-3-carboxamide | 1132649-61-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 7-chloro-N-[2-(ethylamino)ethyl]-2-hydroxy-4-oxopyrido[1,2-a]pyrimidine-3-carboxamide
• CAS: 1132649-61-6
• 化学式: C₁₃H₁₅ClN₄O₃
• 分子量: 310.74
• InChiKey: INXALDPJETVQGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  94
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-乙基乙二胺 、 ethyl 7-chloro-2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylate 以 乙醇 为溶剂， 反应 10.0h， 以85%的产率得到7-chloro-N-[2-(ethylamino)ethyl]-2-hydroxy-4-oxopyrido[1,2-a]pyrimidine-3-carboxamide
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids

  摘要：

  Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.

  DOI：

  10.1007/s10593-008-0012-x

文献信息

• 4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids
  作者：I. V. Ukrainets、N. L. Bereznyakova、I. A. Turaibei

  DOI：10.1007/s10593-008-0012-x

  日期：2008.1

  Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been studied. Results are given of the investigation of cytotoxicity and antiviral activity in relation to type 1 herpes virus and coronavirus.