(Z)-2-methylcyclohexanone oxime | 49805-43-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (Z)-2-methylcyclohexanone oxime
• 英文别名: 2-methylcyclohexanone syn-oxime；syn-2-methylcyclohexanone oxime；2-methylcyclohexanone oxime；2-Methyl-cyclohexanon-Z-oxim；2-Methyl-cyclohexanon-oxim；Z-2-Methylcyclohexanonoxim；(1Z)-2-methylcyclohexanone oxime；(NZ)-N-(2-methylcyclohexylidene)hydroxylamine
• CAS: 49805-43-8
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: MDIFHVYPHRHKLB-FPLPWBNLSA-N

物化性质

• 沸点：
  218.1±9.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  32.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-2-methylcyclohexanone oxime 在 三氟过氧乙酸 作用下， 生成 cis-1-nitro-2-phenylcyclohexanone
  参考文献：
  名称：

  Bowman, W. Russ; Golding, Bernard T.; Watson, William P., journal of the chemical society-perkin transactions 2, 1980, p. 731 - 736

  摘要：

  DOI：
• 作为产物：
  描述：

  环己酮肟 、 碘甲烷 生成 (Z)-2-methylcyclohexanone oxime
  参考文献：
  名称：

  肟双阴离子的反应：烷基化反应中的立体特异性

  摘要：

  DOI：

  10.1016/s0040-4039(00)71277-9

文献信息

• PREPARATION OF CHIRAL AMIDES AND AMINES
  申请人：Zhao Hang

  公开号：US20090149549A1

  公开（公告）日：2009-06-11

  This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.

  这项发明提供了一种方便的方法，将肟转化为烯酰胺。该过程不需要使用金属试剂。因此，它能够产生所需化合物，而不会伴随产生大量金属废物。烯酰胺是酰胺和胺的有用前体。该发明提供了将一个原生手性烯酰胺转化为相应手性酰胺的过程。在一个示范过程中，通过使用手性氢化催化剂，在氢化过程中引入了手性氨基中心。在选定的实施例中，该发明提供了制备酰胺和胺的方法，其中包括1,2,3,4-四氢-N-烷基-1-萘胺或1,2,3,4-四氢-1-萘胺亚结构。
• REGIOSELECTIVE SULFENYLATION OF OXIME DIANIONS. A NOVEL AND USEFUL METHOD FOR THE REGIOSELECTIVE RING CLEAVAGE
  作者：Kunio Hiroi、Masahiko Otsuka、Shuko Sato

  DOI：10.1246/cl.1985.1907

  日期：1985.12.5

  Treatment of the dianions of cyclic ketoximes with diphenyl disulfide underwent a regioselective sulfenylation at the syn α-carbons. Regioselective alkylation of cyclic ketoxime dianions, followed by sulfenylation with diphenyl disulfide, produced α-alkyl-α′-phenylsulfenyl ketoximes. A Beckmann fragmentation of these sulfenylated ketoximes gave ring cleaved products. This procedure provides a synthetically

  用二苯基二硫化物处理环状酮肟的二价阴离子在顺α-碳上发生区域选择性亚磺酰化。环状酮肟双阴离子的区域选择性烷基化，然后用二苯基二硫化物进行亚磺酰化，产生 α-烷基-α'-苯基亚磺酰基酮肟。这些磺基化酮肟的贝克曼断裂得到环裂解产物。该过程为区域选择性环裂解提供了一种综合有用的方法，保留了有价值的功能。
• [EN] 1,2,4-TRIOXOLANE ANTIMALARIALS<br/>[FR] ANTIPALUDIQUES A BASE DE 1,2,4-TRIOXOLANE
  申请人：MEDICINES MALARIA VENTURE MMV

  公开号：WO2003000676A1

  公开（公告）日：2003-01-03

  A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.

  本发明涉及使用螺环或双螺环1,2,4-三噁烷治疗疟疾、血吸虫病和癌症的方法和手段。首选的1,2,4-三噁烷包括一个螺环戊烷基团位于三噁烷基团的一侧，以及一个螺环己基位于三噁烷基团的另一侧，其中螺环己环在4位处优选被取代。与青蒿素半合成衍生物相比，本发明的化合物结构简单，易于合成，无毒，并且对疟原虫具有很强的杀灭作用。
• FUNGICIDAL HETEROCYCLIC COMPOUNDS
  申请人：E. I. DU PONT DE NEMOURS AND COMPANY

  公开号：US20150336985A1

  公开（公告）日：2015-11-26

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, tautomers, N-oxides, and salts thereof, wherein E, X, Y, G, Z and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  本发明涉及一种公式1的化合物，包括所有几何和立体异构体、互变异构体、N-氧化物和其盐，其中E、X、Y、G、Z和Q如本文所定义。本发明还涉及含有公式1化合物的组合物以及用该发明的化合物或组合物施用的方法，以控制由真菌病原体引起的植物病害。
• Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates
  申请人：Merck & Co., Inc.

  公开号：EP0046291A2

  公开（公告）日：1982-02-24

  The invention retates to caprolactam derivatives of the formula wherein R and R are hydroxy, lower alkoxy, lower alkenoxy. aryloxy, difoweralkylamino lower alkoxy, acylamino lower alkoxy, acyloxy lower alkoxy arloweralkoxy. hydroxy lower all oxy. dihydroxy lower alkoxy, amino, hydroxyamino; R is hydrogen. alkyl of from 1 to 12 carbon atoms substituted loweralkyl, arloweralkyl, arloweralkenyl, heteroarlower alkyl or heteroarlower alkenyl, substituted arloweralkyl or substituted heteroarlower alkyl; R2 is hydrogen, lower alkyl, cyclic lower alkyl, amino, aminolower alkyl, alkylaminoloweralkyl, hydroxyalkyl, acylaminoloweralkyl, dialkylaminoloweralkyl, arlower alkyl, aryl, substituted aryl, heteroaryl, heteroarlower alkyl; R3 is hydrogen, lower alkyl, phenyl, phenyl lower alkyl, hydroxyphenyl lower alkyl, hydroxy lower alkyl, amino lower alkyl, acylamino lower aikyl, guanidino lower alkyl, imidazolyl lower alkyl, indolyl lower alkyl, mercapto lower alkyl or lower alkyl thio lower alkyl; and R3 is hydrogen or lower alkyl. These compounds are useful as angiotensin converting enzyme inhibitors and as antihypertensives. The invention relates also to a process for preparing these compounds.

  本发明涉及式如下的己内酰胺衍生物 式中 R和R是羟基、低级烷氧基、低级烯氧基、芳氧基、二低级烷基氨基低级烷氧基、酰氨基低级烷氧基、酰氧基低级烷氧基、羟基低级烷氧基、二羟基低级烷氧基、氨基、羟基氨基； R2 是氢、1 至 12 个碳原子的烷基、取代的低级烷基、低级烷基、低级烯基、杂低级烷基或杂低级烯基、取代的低级烷基或取代的杂低级烷基； R2 是氢、低级烷基、环低级烷基、氨基、氨低级烷基、烷基氨基低级烷基、羟基烷基、酰基氨基低级烷基、二烷基氨基低级烷基、芳基、取代芳基、杂芳基、杂低级烷基； R3 是氢、低级烷基、苯基、苯基低级烷基、羟基苯基低级烷基、羟基低级烷基、氨基低级烷基、酰氨基低级烷基、胍基低级烷基、咪唑基低级烷基、吲哚基低级烷基、巯基低级烷基或硫代低级烷基；和 R3 是氢或低级烷基。 这些化合物可用作血管紧张素转换酶抑制剂和降压药。本发明还涉及制备这些化合物的工艺。