2-(N-methyl-N-prop-2-enyl)pyridine | 501031-16-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(N-methyl-N-prop-2-enyl)pyridine
• 英文别名: N-methyl-N-prop-2-enylpyridin-2-amine
• CAS: 501031-16-9
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: DEBKICBZBNKXIL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (S)-2-pyrrol-1-yl-3-[(4-trifluoromethanesulfonyloxy)phenyl]propionic acid methyl ester 、 2-(N-methyl-N-prop-2-enyl)pyridine 在 palladium diacetate 三乙胺 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 28.0h， 以60%的产率得到(S)-3-{4-[(E)-3-(methyl-pyridin-2-yl-amino)-propenyl]phenyl}-2-pyrrol-1-yl-propionic acid methyl ester
  参考文献：
  名称：

  Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

  摘要：

  A new series of alpha-aryl or alpha-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the commonly used ether moiety that joins the central phenyl ring with the lipophilic tail. The effect of these modi. cations in the binding and activation of PPAR alpha and PPAR gamma was first evaluated in vitro. Compounds possessing suitable profiles were then evaluated in the ob/ob mouse model of type 2 diabetes. The propylene derivative 40 and the propyl derivative 53 demonstrated robust plasma glucose lowering activity in this model. Compound 53 was also evaluated in male Zucker diabetic fatty rats and was found to achieve normalization of glucose, triglycerides, and insulin levels. An X-ray crystal structure of the complex of 53 with the PPAR gamma-ligand-binding domain was obtained and discussed in this report. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.043
• 作为产物：
  描述：

  2-(甲氨基)吡啶 、 3-溴丙烯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以80%的产率得到2-(N-methyl-N-prop-2-enyl)pyridine
  参考文献：
  名称：

  Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies

  摘要：

  A new series of alpha-aryl or alpha-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the commonly used ether moiety that joins the central phenyl ring with the lipophilic tail. The effect of these modi. cations in the binding and activation of PPAR alpha and PPAR gamma was first evaluated in vitro. Compounds possessing suitable profiles were then evaluated in the ob/ob mouse model of type 2 diabetes. The propylene derivative 40 and the propyl derivative 53 demonstrated robust plasma glucose lowering activity in this model. Compound 53 was also evaluated in male Zucker diabetic fatty rats and was found to achieve normalization of glucose, triglycerides, and insulin levels. An X-ray crystal structure of the complex of 53 with the PPAR gamma-ligand-binding domain was obtained and discussed in this report. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.03.043

文献信息

• Process for producing fluorinated isocyanates and carbamates
  申请人：REPSOL YPF S.A.

  公开号：EP2036884A1

  公开（公告）日：2009-03-18

  The invention relates to a process for producing fluorinated carbamates comprising the reaction between an amine or polyamine and a fluorinated carbonate, in the presence of a catalyst which does not contain metals and comprises at least one tertiary amine group. The process can also comprise an additional step in which the carbamates are transformed into the corresponding isocyanates.

  该发明涉及一种生产氟化碳酸酯的方法，包括胺或多胺与氟化碳酸酯在不含金属的催化剂存在下反应，所述催化剂至少包含一个三级胺基团。该方法还可以包括一个额外步骤，将碳酸酯转化为相应的异氰酸酯。
• Process for producing fluorinated carbamates and isocyanates
  申请人：Polo Ana Padilla

  公开号：US20090082588A1

  公开（公告）日：2009-03-26

  The invention relates to a process for producing fluorinated carbamates comprising the reaction between an amine or polyamine and a fluorinated carbonate, in the presence of a catalyst which does not contain metals and comprises at least one tertiary amine group. The process can also comprise an additional step in which the carbamates are transformed into the corresponding isocyanates.

  该发明涉及一种制备氟化碳酸酯的方法，包括胺或多胺与氟化碳酸酯在不含金属的催化剂存在下发生反应，所述催化剂包含至少一个三级胺基团。该方法还可以包括一个额外步骤，其中碳酸酯转化为相应的异氰酸酯。
• Organic electroluminescence devices
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0517542A1

  公开（公告）日：1992-12-09

  An organic electroluminescence device comprising: a luminous layer containing a luminous material and a hole transport material, or a luminous layer containing a luminous material and a hole transport layer containing a hole transport material, between a pair of electrodes at least one of which is transparent or translucent, characterized in that the hole transport material contains an aromatic amine selected from the group consisting of compounds represented by the formulae (1) to (4) wherein each of Ar₁, Ar₂, Ar₃, Ar₄, Ar₅ and Ar₆ independently represents an aromatic hydrocarbon ring group having six or more carbon atoms or an aromatically heterocyclic compound group having four or more carbon atoms, x represents an integer of 2 or more, and each of A₁, A₂, A₃, A₄, A₅, A₆, A₇, A₈, A₉, A₁₀ and A₁₁ independently represents a group selected from the following formulae (5) to (13) (plural A₁₁s may be the same or different); wherein each of R₁ to R₇, R₉ to R₁₁ and R₁₃ to R₁₈ independently represents a member selected from the group consisting of C₁-C₁₂ alkyl and alkoxy groups, C₆-C₁₄ aryl and aryloxy groups, a nitro group and heterocyclic compound groups; when one benzene ring or pyridine ring has plural substituents, they are selected independently; each of R₈ and R₁₂ independently represents a member selected from the group consisting of a hydrogen atom and C₁-C₁₂ alkyl groups; and a, b, c, d, e, f, g, h, i, j, k, l, m, n, o and p represent integers of 0 ≦ a, b, g ≦ 5, 0 ≦ c, d, e, f, h, i, k, m, o, p ≦ 4 and 0 ≦ j, l, n ≦ 3.

  一种有机电致发光器件，包括：在一对电极（其中至少有一个是透明或半透明的）之间的发光层，该发光层含有发光材料和空穴传输材料，或发光层含有发光材料，空穴传输层含有空穴传输材料，其特征在于空穴传输材料含有选自由式（1）至（4）表示的化合物组成的组的芳香胺 其中 Ar₁、Ar₂、Ar₃、Ar₄、Ar₅ 和 Ar₆ 各自独立地代表具有六个或六个以上碳原子的芳香烃环基或具有四个或四个以上碳原子的芳香杂环化合物基团、A₁₀ 和 A₁₁ 独立地代表选自下式 (5) 至 (13) 的基团（复数 A₁₁ 可以相同或不同）； 其中 R₁ 至 R₇、R₉ 至 R₁₁ 和 R₁₃ 至 R₁₈ 各自独立地代表选自由 C₁-C₁₂ 烷基和烷氧基组成的组的成员、C₆-C₁₄芳基和芳氧基、硝基和杂环化合物基团；当一个苯环或吡啶环上有多个取代基时，它们是独立选择的；R₈ 和 R₁₂ 各自独立地代表选自氢原子和 C₁-C₁₂ 烷基的成员；和 a、b、c、d、e、f、g、h、i、j、k、l、m、n、o 和 p 代表 0 ≦ a、b、g ≦ 5、0 ≦ c、d、e、f、h、i、k、m、o、p ≦ 4 和 0 ≦ j、l、n ≦ 3 的整数。
• US7271172B2
  申请人：——

  公开号：US7271172B2

  公开（公告）日：2007-09-18
• Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARα/γ dual agonists, and X-ray crystallographic studies
  作者：Agustin Casimiro-Garcia、Christopher F. Bigge、Jo Ann Davis、Teresa Padalino、James Pulaski、Jeffrey F. Ohren、Patrick McConnell、Christopher D. Kane、Lori J. Royer、Kimberly A. Stevens、Bruce J. Auerbach、Wendy T. Collard、Christine McGregor、Stephen A. Fakhoury、Robert P. Schaum、Hairong Zhou

  DOI：10.1016/j.bmc.2008.03.043

  日期：2008.5

  A new series of alpha-aryl or alpha-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the commonly used ether moiety that joins the central phenyl ring with the lipophilic tail. The effect of these modi. cations in the binding and activation of PPAR alpha and PPAR gamma was first evaluated in vitro. Compounds possessing suitable profiles were then evaluated in the ob/ob mouse model of type 2 diabetes. The propylene derivative 40 and the propyl derivative 53 demonstrated robust plasma glucose lowering activity in this model. Compound 53 was also evaluated in male Zucker diabetic fatty rats and was found to achieve normalization of glucose, triglycerides, and insulin levels. An X-ray crystal structure of the complex of 53 with the PPAR gamma-ligand-binding domain was obtained and discussed in this report. (c) 2008 Elsevier Ltd. All rights reserved.