N-[2-(6-bromoimidazo[1,2-a]pyridin-2-yl)ethyl]-3-methoxybenzamide | 1403658-78-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: N-[2-(6-bromoimidazo[1,2-a]pyridin-2-yl)ethyl]-3-methoxybenzamide
• CAS: 1403658-78-5
• 化学式: C₁₇H₁₆BrN₃O₂
• 分子量: 374.237
• InChiKey: KPSGBUIUGMGDRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[2-(6-bromoimidazo[1,2-a]pyridin-2-yl)ethyl]-3-methoxybenzamide 在 三氯氧磷 作用下， 反应 48.0h， 以54%的产率得到8-bromo-1-(3-methoxyphenyl)-3,4-dihydrodipyrido[1,2-a;4’,3’-d]imidazole dihydrochloride
  参考文献：
  名称：

  Methodology to Access Tetrahydrodipyridoimidazole Derivatives

  摘要：

  While the synthesis of beta and gamma-carboline derivatives were well described in the literature, the preparation of their aza-analogs such as tetrahydrodipyridoimidazole derivatives were less explored. In our laboratory we developed various methods to access to these compounds using Bischler-Napieralski as well as Pictet-Spengler reactions.

  DOI：

  10.3987/com-12-12447
• 作为产物：
  描述：

  2-[2-(6-bromoimidazo[1,2-a]pyridin-2-yl)ethyl]-1Hisoindole-1,3(2H)-dione 在 potassium carbonate 、 一水合肼 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 6.0h， 生成 N-[2-(6-bromoimidazo[1,2-a]pyridin-2-yl)ethyl]-3-methoxybenzamide
  参考文献：
  名称：

  Methodology to Access Tetrahydrodipyridoimidazole Derivatives

  摘要：

  While the synthesis of beta and gamma-carboline derivatives were well described in the literature, the preparation of their aza-analogs such as tetrahydrodipyridoimidazole derivatives were less explored. In our laboratory we developed various methods to access to these compounds using Bischler-Napieralski as well as Pictet-Spengler reactions.

  DOI：

  10.3987/com-12-12447