1,4-Benzenediamine, N-(3-methoxyphenyl)-N-methyl- | 246864-36-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4-Benzenediamine, N-(3-methoxyphenyl)-N-methyl-
• 英文别名: 4-N-(3-methoxyphenyl)-4-N-methylbenzene-1,4-diamine
• CAS: 246864-36-8
• 化学式: C₁₄H₁₆N₂O
• mdl: MFCD15494178
• 分子量: 228.294
• InChiKey: QFGFQZCBBIIQKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  38.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丙酰氯 、 1,4-Benzenediamine, N-(3-methoxyphenyl)-N-methyl- 在 4-二甲氨基吡啶 、 TEA 作用下， 以 二氯甲烷 为溶剂， 生成 N-{4-[(3-Methoxy-phenyl)-methyl-amino]-phenyl}-propionamide
  参考文献：
  名称：

  4-Substituted anilides as selective melatonin MT 2 receptor agonists

  摘要：

  A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT2 binding affinity and MT2 selectivity of at least 70-fold over the MT1 receptor. Compound 26 demonstrated full agonism at the MT2 receptor. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.030
• 作为产物：
  描述：

  4-Nitro-3'-methoxy-diphenyl-amin 在 palladium on activated charcoal 氢氧化钾 、 氢气 作用下， 以 四氢呋喃 为溶剂， 生成 1,4-Benzenediamine, N-(3-methoxyphenyl)-N-methyl-
  参考文献：
  名称：

  4-Substituted anilides as selective melatonin MT 2 receptor agonists

  摘要：

  A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT2 binding affinity and MT2 selectivity of at least 70-fold over the MT1 receptor. Compound 26 demonstrated full agonism at the MT2 receptor. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.030

文献信息

• DETERMINATION OF NON-HDL CHOLESTEROL IN BLOOD
  申请人：Axis-Shield AS

  公开号：EP3435089A1

  公开（公告）日：2019-01-30

  The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component. The method includes: i) diluting the sample with a reagent mixture; ii) substantially removing blood cells; iii) using a reagent which to temporarily prevent reaction of the second component, to generate a blocked second component; iv) causing the selective reaction of a constituent of each analyte to directly or indirectly generate detectable reaction products, where one of the analytes is the first component; v) monitoring the detectable reaction product or products; vi) relating an amount of the detectable product or products and/or a rate of formation of the detectable product or products to the concentration of each analyte, where the concentration of at least the first component is related to a corresponding detectable reaction product by means of estimating an un-measurable (fictive) endpoint. Step iii) may be carried out at any stage up to and including step iv) but before steps v) or vi). The reagent of step iii) may be applied to the sample separately or may be included in a reagent mixture during steps i) or iv). A corresponding kit is also provided.

  本发明提供了一种酶解方法，用于测量血液衍生样本血浆部分中一种或多种分析物的浓度，该样本含有第一和第二成分，其中所述第二成分会干扰所述第一成分的测量。该方法包括 i) 用试剂混合物稀释样品； ii) 基本去除血细胞 iii) 使用一种试剂暂时阻止第二种成分的反应，以产生被阻断的第二种成分； iv) 使每种分析物的一种成分发生选择性反应，直接或间接生成可检测的反应产物，其中一种分析物是第一成分 v) 监测可检测反应产物 vi) 将可检测产物的量和/或可检测产物的形成率与各被分析物的浓度相关联，其中至少第一成分的浓度与相应的可检测反应产物相关联，方法是估计一个不可测量的（虚构的）终点。 步骤 iii) 可以在步骤 iv) 之前的任何阶段进行，但必须在步骤 v) 或 vi) 之前进行。步骤 iii) 的试剂可单独应用于样品，也可在步骤 i) 或 iv) 期间加入试剂混合物中。还提供了相应的试剂盒。
• Blood sample assay method
  申请人：AXIS-SHIELD AS

  公开号：US11085066B2

  公开（公告）日：2021-08-10

  The invention provides an enzymatic method for measuring the concentration of one or more analytes in the plasma portion of a blood derived sample, containing a first and a second component, where said second component interferes with the measurement of said first component. The method includes: i) diluting the sample with a reagent mixture; ii) substantially removing blood cells; iii) using a reagent which serves to temporarily prevent reaction of the second component, to generate a blocked second component; iv) causing the selective reaction of a constituent of each analyte to directly or indirectly generate detectable reaction products, where one of the analytes is the first component; v) monitoring the detectable reaction product or products; vi) relating an amount of the detectable product or products and/or a rate of formation of the detectable product or products to the concentration of each analyte, where the concentration of at least the first component is related to a corresponding detectable reaction product by means of estimating an un-measurable (fictive) endpoint. Step iii) may be carried out at any stage up to and including step iv) but before steps v) or vi). The reagent of step iii) may be applied to the sample separately or may be included in a reagent mixture during steps i) or iv). A corresponding kit is also provided.

  本发明提供了一种酶解方法，用于测量血液衍生样本血浆部分中一种或多种分析物的浓度，该样本含有第一和第二成分，其中所述第二成分会干扰所述第一成分的测量。该方法包括i) 用试剂混合物稀释样品； ii) 基本去除血细胞； iii) 使用一种试剂暂时阻止第二种成分的反应，生成被阻断的第二种成分； iv) 使每种分析物的一种成分发生选择性反应，直接或间接生成可检测的反应产物，其中一种分析物是第一种成分；v) 监测可检测反应产物； vi) 将可检测产物的量和/或可检测产物的形成率与各被分析物的浓度相关联，其中至少第一成分的浓度与相应的可检测反应产物相关联，方法是估计不可测量（虚构）终点。步骤 iii) 可以在步骤 iv) 之前的任何阶段进行，但必须在步骤 v) 或 vi) 之前进行。步骤 iii) 的试剂可单独应用于样品，也可在步骤 i) 或 iv) 期间加入试剂混合物中。还提供了相应的试剂盒。
• METHOD TO DETERMINE LIPIDS
  申请人：Axis-Shield Asa

  公开号：EP2235543A1

  公开（公告）日：2010-10-06
• BLOOD SAMPLE ASSAY METHOD
  申请人：Axis-Shield AS

  公开号：EP2751575B1

  公开（公告）日：2018-09-12
• US5972294A
  申请人：——

  公开号：US5972294A

  公开（公告）日：1999-10-26