(1,2,3,4-tetrahydronaphthalen-1-yl)methyl acetate | 70755-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (1,2,3,4-tetrahydronaphthalen-1-yl)methyl acetate
• 英文别名: Essigsaeure-<1,2,3,4-tetrahydro-<1>naphthylmethylester>；acetic acid-(1,2,3,4-tetrahydro-[1]naphthylmethyl ester)；Essigsaeure-(1,2,3,4-tetrahydro-[1]naphthylmethylester)；(+/-)-1-Acetoxymethyl-1.2.3.4-tetrahydro-naphthalin；(+/-)-1-Acetoxymethyl-tetralin；1,2,3,4-tetrahydronaphthalen-1-ylmethyl acetate
• CAS: 70755-03-2
• 化学式: C₁₃H₁₆O₂
• 分子量: 204.269
• InChiKey: DBLBFKHCLPPYRH-UHFFFAOYSA-N

物化性质

• 沸点：
  294.8±9.0 °C(Predicted)
• 密度：
  1.053±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (1,2,3,4-tetrahydronaphthalen-1-yl)methyl acetate 在 lipase from C_. rugosa 、 potassium carbonate 作用下， 以 甲醇 、 正己烷 为溶剂， 反应 4.0h， 生成 (S)-1-hydroxymethyl-1,2,3,4-tetrahydronaphthalene
  参考文献：
  名称：

  利用顺序脂肪酶催化的反应来获得对映体纯的手性伯醇†

  摘要：

  用乙酸乙烯酯对含苯并稠合的环烷烃的伯醇进行脂肪酶催化的对映选择性乙酰化，并分离出对映纯的醇。洋葱，南美白对虾，南极南美白对虾，萤光假单胞菌，圆柱状对虾和小黑背对虾的脂肪酶对这些醇的乙酰化显示出显着的活性，从而提供了具有高转化率的相应乙酸酯。由于对伯醇的高脂肪酶活性，对映选择性低。为了解决这个问题，采用对映体互补脂肪酶进行顺序动力学拆分，得到对映体纯的伯醇。该方法代表了一种获得带有环体系的手性结构单元的新方法，例如茚满，苯并二氢吡喃和四氢萘。

  DOI：

  10.1039/c5ra06469d
• 作为产物：
  描述：

  1-萘甲醛 、 溶剂黄146 在 Co catalyst 锌 作用下， 以 水 为溶剂， 生成 (1,2,3,4-tetrahydronaphthalen-1-yl)methyl acetate
  参考文献：
  名称：

  钴（I）丙氨酰胺作为催化剂第4部分。还原α，β-不饱和腈

  摘要：

  钴（I）阿拉明作为催化剂。4.沟通。还原α，β-不饱和腈

  DOI：

  10.1002/hlca.19790620327

文献信息

• The slippery slope of constructivism
  作者：Terry Brumley Northcut、Nina Rovinelli Heller

  DOI：10.1080/00377310209517656

  日期：2002.3

  While constructivism as both a philosophy and a clinical practice is being embraced by many individual and family practitioners, it remains controversial. This paper examines the difficulties one encounters in trying to balance the client's "relative truths" with those around them, including that of the therapist. Through the use of clinical vignettes, the authors demonstrate the difficulties inherent in dealing with ambiguities in the clinical situation, balancing the client's perspective, with that of a predominant culture or biological "fact," and considering the issue of the client's "veracity." Particular attention is paid to the difficulties involved in work with trauma survivors, whose own recollections of events may be ambiguous. Finally, the authors discuss the implications that constructivism holds for research and social action and advocacy. In sum, the authors recognize significant promise in the constructivist perspective, but caution clinicians to consider the inherent difficulties in a theory that relies on the relativity of truth.
• Cob (I)alamin als Katalysator 4. Mitteilung. Reduktion von ?,?-unges�ttigten Nitrilen
  作者：Albert Fischli

  DOI：10.1002/hlca.19790620327

  日期：1979.4.20

  Cob(I)alamin as Catalyst. 4. Communication. Reduction of α,β-Unsaturated Nitriles

  钴（I）阿拉明作为催化剂。4.沟通。还原α，β-不饱和腈
• Exploiting sequential lipase-catalyzed reactions to achieve enantiomerically pure chiral primary alcohols
  作者：Rodrigo S. Martins、Anees Ahmad、Luiz F. Silva、Leandro H. Andrade

  DOI：10.1039/c5ra06469d

  日期：——

  cycloalkane-containing primary alcohols with vinyl acetate was performed and allowed the isolation of enantiopure alcohols. Lipases from P. cepacia, C. rugosa, C. antarctica, P. fluorescens, C. cylindracea and M. miehei exhibited remarkable activity towards acetylation of these alcohols, affording the corresponding acetates with high conversion. Due to the high lipase activity toward primary alcohols, the enantioselectivity

  用乙酸乙烯酯对含苯并稠合的环烷烃的伯醇进行脂肪酶催化的对映选择性乙酰化，并分离出对映纯的醇。洋葱，南美白对虾，南极南美白对虾，萤光假单胞菌，圆柱状对虾和小黑背对虾的脂肪酶对这些醇的乙酰化显示出显着的活性，从而提供了具有高转化率的相应乙酸酯。由于对伯醇的高脂肪酶活性，对映选择性低。为了解决这个问题，采用对映体互补脂肪酶进行顺序动力学拆分，得到对映体纯的伯醇。该方法代表了一种获得带有环体系的手性结构单元的新方法，例如茚满，苯并二氢吡喃和四氢萘。