4,7-dimethyl-2H-isoindole | 70187-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4,7-dimethyl-2H-isoindole
• 英文别名: 2H-Isoindole, 4,7-dimethyl-；4,7-dimethyl-2H-isoindole
• CAS: 70187-62-1
• 化学式: C₁₀H₁₁N
• mdl: MFCD19218582
• 分子量: 145.204
• InChiKey: CFFSDFXMZAJNOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  4,7-dimethyl-2H-isoindole 、 dimethyl azodicarboxylate 以70%的产率得到methyl N-(4,7-dimethyl-2H-isoindol-1-yl)-N-(methoxycarbonylamino)carbamate
  参考文献：
  名称：

  2H-异吲哚多酚偶氮-对羟基苯并二氢呋喃酮（Reaktionen von 2H-isoindolen mit aktivierten azo-verbindungen）

  摘要：

  已经研究了烷基取代的2H-异吲哚对偶氮二羧酸二烷基酯的化学行为，并阐明了所形成的1：1-和1：2-加合物的结构。邻醌类戊烯与活化的亲二烯体的反应可以被认为是迈克尔加成反应。

  DOI：

  10.1016/s0040-4039(00)78717-x
• 作为产物：
  描述：

  4,7-Dimethyl-2-prop-2-ynyl-2,3-dihydro-1H-isoindole 生成 4,7-dimethyl-2H-isoindole
  参考文献：
  名称：

  Kreher, Richard P.; Kohl, Norbert, Angewandte Chemie, 1984, vol. 96, # 7, p. 507 - 508

  摘要：

  DOI：

文献信息

• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• METHOD FOR AMPLIFYING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2218716A1

  公开（公告）日：2010-08-18

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided. A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar1, R1, R2, R3, R4, R5, R6 and R7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.

  本研究提供了一种造血干细胞和/或造血祖细胞扩增剂，可提高基因转移到造血干细胞中的效率，用于治疗各种造血疾病的基因治疗。 一种扩增造血干细胞和/或造血祖细胞的方法，包括在由式(I)代表的化合物（其中X、Y、X、Ar1、R1、R2、R3、R4、R5、R6和R7在描述中定义）、该化合物的同系物或药学上可接受的盐或其溶液存在下，体外培养造血干细胞和/或造血祖细胞。
• CYCLOPARA(HETERO)ARYLENE COMPOUND AND METHOD FOR PRODUCING SAME
  申请人：Kyoto University

  公开号：EP2484656A1

  公开（公告）日：2012-08-08

  Provided are a cyclopara(hetero)arylene compound and a method for producing the same. More specifically, provided is a cycloparaphenylene compound represented by Formula (I): wherein Ar1, Ar2, Ar3, and Ar4 are the same or different, and represent an optionally substituted divalent aromatic group or an optionally substituted divalent heteroaromatic group, and n1, n2, n3, and n4 are the same or different, and represent an integer of 1 or more.

  本发明提供了一种环(杂)芳基烯化合物及其生产方法。更具体地说，提供了一种由式（I）表示的环联苯化合物： 其中 Ar1、Ar2、Ar3 和 Ar4 相同或不同，代表任选取代的二价芳香族基团或任选取代的二价杂芳香族基团，以及 n1、n2、n3 和 n4 相同或不同，且代表 1 或更大的整数。
• METHOD FOR PRODUCING POLYISOTHIANAPHTHENE ELECTROCONDUCTIVE POLYMER
  申请人：Showa Denko K.K.

  公开号：EP3564290A1

  公开（公告）日：2019-11-06

  The present invention relates to (i) a method of producing a conductive polymer, comprising polymerizing at least one of compounds (A1) represented by the formula (1) disclosed in the specification in the presence of a compound (B) having sulfo group; (ii) a method of producing a conductive polymer, comprising polymerizing at least one compound selected from a group consisting of at least one compound (A2) represented by the formula (2); and (iii) a method of producing a conductive polymer, comprising copolymerizing at least one compound (A1) and at least one compound selected from a group consisting of at least one compound (A2). The method of the present invention is a method for producing a one-liquid type conductive polymer in which it is possible to easily adjust the solvent affinity, the solubility, and other such aspects of performance according to the purpose.

  本发明涉及(i)生产导电聚合物的方法，包括在具有磺基的化合物(B)存在下聚合至少一种由说明书中公开的式(1)代表的化合物(A1)；(iii) 一种生产导电聚合物的方法，包括将至少一种化合物(A1)和至少一种选自至少 一种化合物(A2)的化合物共聚。本发明的方法是一种生产单液型导电聚合物的方法，在这种方法中，可以根据目的轻松调整溶剂亲和性、溶解性和其他性能方面。
• METHOD FOR MANUFACTURING SOLID ELECTROLYTIC CAPACITOR
  申请人：Showa Denko K.K.

  公开号：EP3564976A1

  公开（公告）日：2019-11-06

  The present invention relates to a method of producing a solid electrolytic capacitor, comprising a step of forming a dielectric film on the surface of the valve-acting metal having fine pores and a step of forming a solid electrolyte layer containing a conductive polymer on the dielectric film; wherein the solid electrolyte layer containing the conductive polymer is formed without using an oxidizing agent by: (i) a method of polymerizing at least one of the compounds (A1) represented by the formula (1) disclosed in the description in the presence of a compound (B) having sulfo group; (ii) a method of copolymerizing at least one compound (A2) represented by the formula (2); and (iii) a method of polymerizing at least one of the compounds (A1) represented by the formula (1) and at least one of the compounds (A2) represented by the formula (2). According to the present invention, it is possible to form a solid electrolyte film containing a conductive polymer on the dielectric film on the surface of valve-acting metal having fine pores by simple steps without employing a cumbersome polymerization step, film-formation step, or a purification step; and to provide a solid electrolytic capacitor having a low ESR, a high capacity achievement rate, and excellent low leakage current characteristics.

  本发明涉及一种生产固体电解电容器的方法，包括在具有细孔的阀动金属表面上形成电介质膜的步骤和在电介质膜上形成含有导电聚合物的固体电解质层的步骤；其中，含有导电聚合物的固体电解质层是在不使用氧化剂的情况下通过以下方法形成的： (i) 在具有磺基的化合物(B)存在下聚合至少一种由描述中公开的式(1)代表的化合物 (A1)的方法； (ii) 至少一种由式(2)表示的化合物(A2)的共聚合方法；和 (iii) 至少一种由式(1)代表的化合物(A1)和至少一种由式(2)代表的化合物(A2)聚合的方法。根据本发明，可以通过简单的步骤在具有细孔的阀动金属表面的电介质膜上形成含有导电聚合物的固体电解质膜，而无需采用繁琐的聚合步骤、成膜步骤或纯化步骤；并提供具有低 ESR、高容量实现率和优异的低漏电流特性的固体电解电容器。