3-(三氟甲基)-[1,1-联苯]-4-羧酸 | 1214370-72-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(三氟甲基)-[1,1-联苯]-4-羧酸
• 英文名称: 3-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid
• 英文别名: 4-phenyl-2-(trifluoromethyl)benzoic acid
• CAS: 1214370-72-5
• 化学式: C₁₄H₉F₃O₂
• 分子量: 266.21
• InChiKey: FNUZPUYKDLEJNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE
  申请人：Barbosa Joseph

  公开号：US20100081691A1

  公开（公告）日：2010-04-01

  This invention relates to multicyclic compounds, pharmaceutical compositions comprising them, and methods of their use in, for example, the treatment of cognitive disorders.

  本发明涉及多环化合物、包含它们的药物组合物以及它们在治疗认知障碍等方面的使用方法。
• PYRROLIDINE OXADIAZOLE- AND THIADIAZOLE OXIME DERIVATIVES BEING OXYTOCIN RECEPTOR ANTAGONISTS.
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1444225A2

  公开（公告）日：2004-08-11
• US8772291B2
  申请人：——

  公开号：US8772291B2

  公开（公告）日：2014-07-08
• [EN] PYRROLIDINE OXADIAZOLE- AND THIADIAZOLE DERIVATIVES<br/>[FR] DERIVES DE PYRROLIDINE OXADIAZOLES ET THIADIAZOLES
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2002102799A2

  公开（公告）日：2002-12-27

  The present invention is related to pyrrolidine oxadiazole and thiadiazole derivatives for use as pharmaceutically active compounds, as well as pharmaceutical formulations containing such pyrrolidine oxadiazole derivatives. Said pyrrolidine derivatives are useful in the treatment and/or prevention of preterm labor, premature birth and dysmenorrhea. In particular, the present invention is related to pyrrolidine derivatives displaying a substantial modulatory, notably an antagonist activity of the oxytocin receptor. More preferably, said compounds are useful in the treatment and/or prevention of disease states mediated by oxytocin, including preterm labor, premature birth and dysmenorrhea. The present invention is furthermore related to novel pyrrolidine derivatives as well as to methods of their preparation. (I) B is a oxadiazole or thiadiazole group.