9-<(1-hydroxy-2(S)-butoxy)methyl>guanine | 117039-95-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-<(1-hydroxy-2(S)-butoxy)methyl>guanine
• 英文别名: 9-[(1-hydroxy-2(S)-butoxy)methyl]guanine；2-amino-9-[[(1S)-1-(hydroxymethyl)propoxy]methyl]-1H-purin-6-one；2-amino-9-[[(2S)-1-hydroxybutan-2-yl]oxymethyl]-1H-purin-6-one
• CAS: 117039-95-9
• 化学式: C₁₀H₁₅N₅O₃
• 分子量: 253.261
• InChiKey: HNZUVOSJSMIACT-LURJTMIESA-N

物化性质

• 密度：
  1.59±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-6-氯嘌呤 在 palladium dihydroxide 硫酸氢铵 、 sodium hydroxide 、 氰化汞 、 六甲基二硅氮烷 、 环己烯 作用下， 以 甲醇 、 乙醇 、 水 为溶剂， 反应 7.5h， 生成 9-<(1-hydroxy-2(S)-butoxy)methyl>guanine
  参考文献：
  名称：

  1'，2'-癸二脱氧核苷可作为潜在的抗HIV药物。

  摘要：

  由（R）-苄基缩水甘油制备1'，2'-seco-2'，3'-二脱氧胞苷（12），-鸟苷（14），-腺苷（16）和-肌苷（18）作为潜在的抗HIV抗体代理商。当与ddAdo相比在保护ATH8细胞方面被发现是无活性的。

  DOI：

  10.1021/jm00121a016

文献信息

• FUNCTIONAL MOLECULE, FUNCTIONAL MOLECULE SYNTHESIZING AMIDITE AND TARGET SUBSTANCE ANALYSIS METHOD
  申请人：FUJIHARA Tsuyoshi

  公开号：US20090053710A1

  公开（公告）日：2009-02-26

  To provide a functional molecule including a modified nucleotide unit having a substituent introduced to a base thereof, wherein the substituent is removably introduced to the base; a functional molecule synthesizing amidite that has a substituent removably introduced to its base and that is used for the manufacture of the functional molecule; and a target substance analysis method including: preparing a random pool of functional molecules using a functional molecule synthesizing amidite; screening a functional molecule having affinity for a target substance from the random pool; amplifying the functional molecules having affinity for the target substance, wherein the method further comprises, prior to the amplification step, removing a substituent from the functional molecule having affinity for the target substance.

  提供一种功能分子，其中包括具有引入取代基的修饰核苷酸单元，其中取代基可被移除，以及用于制造该功能分子的功能分子合成酰胺；还提供一种目标物分析方法，包括：使用功能分子合成酰胺制备随机池的功能分子；从随机池筛选出具有亲和力的功能分子；扩增具有亲和力的功能分子，其中该方法还包括，在扩增步骤之前，从具有亲和力的功能分子中去除取代基。
• PHOTOCLEAVABLE LABELED NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN DNA SEQUENCING
  申请人：Wu Weidong

  公开号：US20090081686A1

  公开（公告）日：2009-03-26

  Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker to a photocleavable terminating group. The photocleavable-fluorescent group is designed to terminate DNA synthesis as well as be cleaved so that DNA oligomers can be sequenced efficiently in a parallel format. The design of such rapidly cleavable fluorescent groups on nucleotides and nucleosides can enhance the speed and accuracy of sequencing of large oligomers of DNA in parallel, to allow rapid whole genome sequencing, and the identification of polymorphisms and other valuable genetic information, as well as allowing further manipulation and analysis of nucleic acid molecules in their native state following cleavage of the fluorescent group.

  本文介绍了一些新型的核苷酸、核苷和它们的衍生物，可以用于DNA测序技术和其他类型的DNA分析。在一个实施例中，带有未保护的3'-OH基团的核苷酸或核苷在核碱基处衍生化，包括通过连接剂连接的荧光染料和光解终止基团。光解荧光基团旨在终止DNA合成，同时被裂解，以便在并行格式中高效地测序DNA寡聚物。在核苷酸和核苷上设计这种快速可裂解的荧光基团可以增强大型DNA寡聚物并行测序的速度和准确性，以实现快速的全基因组测序，并识别多态性和其他有价值的遗传信息，同时在裂解荧光基团后允许进一步操作和分析核酸分子的自然状态。
• US7964352B2
  申请人：——

  公开号：US7964352B2

  公开（公告）日：2011-06-21
• 1',2'-seco-Dideoxynucleosides as potential anti-HIV agents
  作者：Elie Abushanab、Mallela S. P. Sarma

  DOI：10.1021/jm00121a016

  日期：1989.1

  1',2'-seco-2',3'-Dideoxycytidine (12), -guanosine (14), -adenosine (16), and -inosine (18) were prepared from (R)-benzylglycidol as potential anti-HIV agents. When compared to ddAdo in protecting ATH8 cells, they were found to be inactive.

  由（R）-苄基缩水甘油制备1'，2'-seco-2'，3'-二脱氧胞苷（12），-鸟苷（14），-腺苷（16）和-肌苷（18）作为潜在的抗HIV抗体代理商。当与ddAdo相比在保护ATH8细胞方面被发现是无活性的。