3-{[5-(4-amino-phenyl)-pyridin-3-ylamino]-methyl}-phenol | 821784-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-{[5-(4-amino-phenyl)-pyridin-3-ylamino]-methyl}-phenol
• 英文别名: Phenol, 3-[[[5-(4-aminophenyl)-3-pyridinyl]amino]methyl]-；3-[[[5-(4-aminophenyl)pyridin-3-yl]amino]methyl]phenol
• CAS: 821784-50-3
• 化学式: C₁₈H₁₇N₃O
• 分子量: 291.352
• InChiKey: RQYNWWQMPILBBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  71.2
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Compounds Which Bind to the Active Site of Protein Kinase Enzymes
  申请人：Birault Veronique

  公开号：US20090163515A1

  公开（公告）日：2009-06-25

  The present invention relates to a compound and a group of compounds which are inhibitors of Rho kinase (ROK, ROCK). In addition, the invention relates to methods of treatment and use of the compounds in the manufacture of a medicament for application to a number of therapeutic indications including cardiovascular disease (coronary vasospasm, hypertensive disease, arteriosclerosis), stroke, cancer, erectile dysfunction, asthma, osteoporosis, glaucoma and AIDS. The compounds can be used in screening programmes against protein kinases. The invention also provides methods for making compounds and libraries that include these compounds.