[Co(o-phenylenediamine)2Cl2] | 68264-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Co(o-phenylenediamine)2Cl2]
• 英文别名: Benzene-1,2-diamine;cobalt(2+);dichloride
• CAS: 68264-83-5
• 化学式: C₁₂H₁₆Cl₂CoN₄
• 分子量: 346.185
• InChiKey: PZZGSXKUTASHQO-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.29
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  [Co(o-phenylenediamine)2Cl2] 、 邻苯二甲醛 以 甲醇 为溶剂， 以65%的产率得到dichloro[3,4,7,8,11,12,15,16-tetrabenzo-2,5,10,13-tetraazacyclohexadecane-1,5,9,13-tetraene]cobalt(II)
  参考文献：
  名称：

  Metal ion-directed synthesis of 16-membered tetraazamacrocyclic complexes and their physico-chemical studies

  摘要：

  Complexes of Co(II), Ni(II), Cu(II) and Zn(II) containing macrocyclic tetradentate nitrogen donor (N-4) ligand have been synthesized from the template condensation reaction between o-phthalaldehyde and o-phenylenediamine. The newly synthesized ligand and its complexes have been characterized on the basis of results of elemental analysis, molar conductance, magnetic susceptibility measurements, FT-IR, electronic, H-1 FT NMR spectral data and Job's method. Their thermal behaviour has been studied by the thermogravimetric analysis. An octahedral geometry has been proposed for all of these complexes except the copper complexes, which show distorted octahedral geometry. The low conductivity data suggest their non-ionic nature. The biological activities of the metal complexes have also been studied against different bacteria. (c) 2005 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2005.07.050
• 作为产物：
  描述：

  cobalt(II) chloride hexahydrate 、 邻苯二胺 以 甲醇 为溶剂， 生成 [Co(o-phenylenediamine)2Cl2]
  参考文献：
  名称：

  Synthesis, Spectral Characterization and Biological Evaluation of Glutaric acid based Macrocyclic Complexes

  摘要：

  在二价过渡金属离子以氯化物形式存在的情况下，利用戊二酸和邻苯二胺设计并合成了一系列独特的大环配合物。利用紫外-可见光、红外光谱、ESR 和 ESI-MS 光谱方法分析了这些新设计的配合物。为了评估它们的热行为，还采用了 TGA 分析法。生成的配合物的通式为 [M(L)X2]（L = 配体，X = Cl-，M = Co2+、Ni2+ 和 Cu2+）。中心金属离子被八面体环境包围。测试了这些大环复合物对所选细菌菌株（金黄色葡萄球菌、枯草芽孢杆菌、绿脓杆菌和大肠杆菌）以及真菌菌株（黑曲霉和白色念珠菌）的抗菌效果，并分别将其药效与标准药物链霉素和伊曲康唑进行了比较。此外，还使用 DPPH 法评估了大环复合物的抗氧化活性。

  DOI：

  10.14233/ajchem.2023.28087

文献信息

• Metal ion-directed synthesis of 16-membered tetraazamacrocyclic complexes and their physico-chemical studies
  作者：Mohammad Shakir、Hamida-Tun-Nisa Chishti、Poonam Chingsubam

  DOI：10.1016/j.saa.2005.07.050

  日期：2006.5

  Complexes of Co(II), Ni(II), Cu(II) and Zn(II) containing macrocyclic tetradentate nitrogen donor (N-4) ligand have been synthesized from the template condensation reaction between o-phthalaldehyde and o-phenylenediamine. The newly synthesized ligand and its complexes have been characterized on the basis of results of elemental analysis, molar conductance, magnetic susceptibility measurements, FT-IR, electronic, H-1 FT NMR spectral data and Job's method. Their thermal behaviour has been studied by the thermogravimetric analysis. An octahedral geometry has been proposed for all of these complexes except the copper complexes, which show distorted octahedral geometry. The low conductivity data suggest their non-ionic nature. The biological activities of the metal complexes have also been studied against different bacteria. (c) 2005 Elsevier B.V. All rights reserved.
• Synthesis, Spectral Characterization and Biological Evaluation of Glutaric acid based Macrocyclic Complexes
  作者：Rajrani Gulia Rajrani gulia、Vikas Sangwan Vikas Sangwan、Anshul Singh Anshul

  DOI：10.14233/ajchem.2023.28087

  日期：——

  In the presence of divalent transition metal ions in their chloride forms, glutaric acid and o-phenylenediamine were used to design and synthesize a unique series of macrocyclic complexes. The UV-Visible, IR, ESR, and ESI-MS spectroscopy methods were used to analyze these newly designed complexes. In order to evaluate their thermal behavior, TGA analysis was employed. The intended general formula for the produced complexes was [M(L)X2] (L = ligand, X = Cl- and M = Co2+, Ni2+ and Cu2+). The central metal ions are  surrounded by octahedral environment. These macrocyclic complexes were tested for their antimicrobial effectiveness against the  selected bacterial strains (Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Escherichia coli), as well as fungi strains  (Aspergillus niger and Candida albicans) and their efficacy was compared to that of standard drugs Streptomycin and Itraconazole respectively. Moreover, the antioxidant activity of the macrocyclic complexes were also assessed using the DPPH assay. 

  在二价过渡金属离子以氯化物形式存在的情况下，利用戊二酸和邻苯二胺设计并合成了一系列独特的大环配合物。利用紫外-可见光、红外光谱、ESR 和 ESI-MS 光谱方法分析了这些新设计的配合物。为了评估它们的热行为，还采用了 TGA 分析法。生成的配合物的通式为 [M(L)X2]（L = 配体，X = Cl-，M = Co2+、Ni2+ 和 Cu2+）。中心金属离子被八面体环境包围。测试了这些大环复合物对所选细菌菌株（金黄色葡萄球菌、枯草芽孢杆菌、绿脓杆菌和大肠杆菌）以及真菌菌株（黑曲霉和白色念珠菌）的抗菌效果，并分别将其药效与标准药物链霉素和伊曲康唑进行了比较。此外，还使用 DPPH 法评估了大环复合物的抗氧化活性。