N-(3-aminopropyl)-N-[1-(3-benzyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-2-yl)propyl]-4-bromobenzamide | 866611-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: N-(3-aminopropyl)-N-[1-(3-benzyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-2-yl)propyl]-4-bromobenzamide
• 英文别名: N-(3-aminopropyl)-N-[1-(3-benzyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-2-yl)propyl]-4-bromobenzamide
• CAS: 866611-03-2
• 化学式: C₂₈H₃₃BrN₄O₂
• 分子量: 537.5
• InChiKey: ZBJDITQFBYJTLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  35
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  79
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  tert-butyl 3-[[1-(3-benzyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-2-yl)propyl](4-bromobenzoyl)amino]propylcarbamate 以 三氟乙酸 、 二氯甲烷 为溶剂， 反应 2.0h， 以yielding 0.0058 g (0.01, 50%) of N-(3-aminopropyl)-N-[1-(3-benzyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-2-yl)propyl]-4-bromobenzamide (1) as a white solid的产率得到N-(3-aminopropyl)-N-[1-(3-benzyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-2-yl)propyl]-4-bromobenzamide
  参考文献：
  名称：

  Mitotic Kinesin Inhibitors

  摘要：

  本发明涉及用于治疗细胞增殖性疾病、治疗至少部分由KSP介导的疾病以及抑制KSP的化合物。本发明还涉及包含这些化合物的制药组合物，通过给予这些组合物治疗癌症的方法，以及制备这些化合物的方法。本发明的化合物具有以下式子：式子（I）。

  公开号：

  US20080249112A1

文献信息

• Mitotic kinesin inhibitors
  申请人：Wang Weibo

  公开号：US20050228002A1

  公开（公告）日：2005-10-13

  The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The invention also related to pharmaceutical compositions comprising such compounds, methods of treating cancer by the administration of such compositions, and processes for the preparation of the compounds. Compounds of the invention have the following formula:

  本发明涉及用于治疗细胞增殖性疾病，治疗至少部分由KSP介导的疾病以及抑制KSP的化合物。本发明还涉及包含这种化合物的制药组合物，通过给予这种组合物治疗癌症的方法，以及制备这种化合物的方法。本发明的化合物具有以下结构式：
• MITOTIC KINESIN INHIBITORS
  申请人：Wang Weibo

  公开号：US20090171082A1

  公开（公告）日：2009-07-02

  The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The invention also related to pharmaceutical compositions comprising such compounds, methods of treating cancer by the administration of such compositions, and processes for the preparation of the compounds. Compounds of the invention have the following formula:

  本发明涉及用于治疗细胞增殖性疾病、治疗至少部分由KSP介导的疾病以及抑制KSP的化合物。本发明还涉及包含这些化合物的药物组合物、通过给予这些组合物治疗癌症的方法，以及制备这些化合物的过程。本发明的化合物具有以下结构式：
• US7504405B2
  申请人：——

  公开号：US7504405B2

  公开（公告）日：2009-03-17
• [EN] MITOTIC KINESIN INHIBITORS<br/>[FR] INHIBITEURS DE LA KINESINE MITOTIQUE
  申请人：CHIRON CORP

  公开号：WO2005100357A1

  公开（公告）日：2005-10-27

  The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The invention also related to pharmaceutical compositions comprising such compounds, methods of treating cancer by the administration of such compositions, and processes for the preparation of the compounds. Compounds of the invention have the following formula : formula (I).
• Mitotic Kinesin Inhibitors
  申请人：Wang Weibo

  公开号：US20080249112A1

  公开（公告）日：2008-10-09

  The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The invention also related to pharmaceutical compositions comprising such compounds, methods of treating cancer by the administration of such compositions, and processes for the preparation of the compounds. Compounds of the invention have the following formula: formula (I).

  本发明涉及用于治疗细胞增殖性疾病、治疗至少部分由KSP介导的疾病以及抑制KSP的化合物。本发明还涉及包含这些化合物的制药组合物，通过给予这些组合物治疗癌症的方法，以及制备这些化合物的方法。本发明的化合物具有以下式子：式子（I）。