4-cyano-N-[(2R)-2-piperazin-1-ylpropyl]-N-pyridin-2-ylbenzamide | 865411-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-cyano-N-[(2R)-2-piperazin-1-ylpropyl]-N-pyridin-2-ylbenzamide
• CAS: 865411-01-4
• 化学式: C₂₀H₂₃N₅O
• 分子量: 349.4
• InChiKey: XZBZCEPDEKZETC-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  72.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PHARMACEUTICAL DOSAGE FORMS AND COMPOSITIONS OF 5-HT1A RECEPTOR ANTAGONISTS
  申请人：Wyeth

  公开号：EP1730139A2

  公开（公告）日：2006-12-13
• PHARMACEUTICAL DOSAGE FORMS AND COMPOSITIONS COMPRISING LECOZTAN
  申请人：Wyeth

  公开号：EP1928863A2

  公开（公告）日：2008-06-11
• Pharmaceutical dosage forms and compositions
  申请人：Ghosh Krishnendu

  公开号：US20050215561A1

  公开（公告）日：2005-09-29

  This invention relates to, for example, novel formulations and methods for the delivery of 4-cyano-N-(2R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5yl)-piperazin-1-yl]-propyl}-N-pyridin-2-yl-benzamide, pharmaceutically acceptable salts thereof, structurally related compounds and/or metabolites; as well as to use of these formulations and methods for treating disease.
• [EN] PHARMACEUTICAL DOSAGE FORMS AND COMPOSITIONS<br/>[FR] FORMES POSOLOGIQUES PHARMACEUTIQUES ET COMPOSITIONS
  申请人：WYETH CORP

  公开号：WO2005092307A2

  公开（公告）日：2005-10-06

  This invention relates to, for example, novel formulations and methods for the delivery of 4-­cyano-N- (2R)-2-[4-(2,3-dihydro-benzo[1,4]dioxin-5 yl)-piperazin-l-yl]-propyl}-N-pyridin-2-yl­benzamide, pharmaceutically acceptable salts thereof, structurally related compounds and/or metabolites; as well as to use of these formulations and methods for treating disease.
• [EN] PHARMACEUTICAL DOSAGE FORMS AND COMPOSITIONS<br/>[FR] FORMES DOSIFIEES PHARMACEUTIQUES ET COMPOSITIONS ASSOCIEES
  申请人：WYETH CORP

  公开号：WO2007030589A2

  公开（公告）日：2007-03-15

  [EN] The invention relates to, for example, novel formulations and methods for the delivery of 4-cyano-N-(2R)-2-[4-(2,3-dihydro-benzo[l ,4]dioxin-5-yl)-piperazin-l -yl]-propyl}-N- pyridin-2-yl-benzamide, pharmaceutically acceptable salts thereof, structurally related compounds and/or metabolites; as well as to use of these formulations and methods for treating disease.
  [FR] L'invention concerne, par exemple de nouvelles formulations et de nouvelles méthodes pour distribuer du 4-cyano-N-(2R)-2-[4-(2,3-dihydro-benzo[l,4]dioxin-5-yl)-piperazin-l -yl]-propyl}-N- pyridin-2-yl-benzamide, des sels pharmaceutiquement acceptables de celui-ci, des composés structurellement associés à celui-ci et/ou des métabolites structurellement associés à celui-ci. L'invention concerne également l'utilisation de ces formulations et de ces méthodes pour traiter des maladies.