3-(二乙基膦)丙酸 | 3095-96-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 3-(二乙基膦)丙酸
• 中文别名: 3-(二乙氧基氧膦基)丙酸
• 英文名称: β-diethoxyphosphorylpropionic acid
• 英文别名: 3-(Diethoxyphosphoryl)propionic acid；3-(diethoxyphosphinyl)propionic acid；3-(diethoxyphosphoryl)propanoic acid；3-(diethylphosphono)propanoic acid；3-(diethylphosphono)propionic acid；3-diethoxyphosphorylpropanoic acid
• CAS: 3095-96-3
• 化学式: C₇H₁₅O₅P
• mdl: MFCD00466707
• 分子量: 210.167
• InChiKey: YLIOJOOKMJEHJM-UHFFFAOYSA-N

物化性质

• 熔点：
  >15°C
• 沸点：
  334.4±25.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)
• 闪点：
  >110°C
• 溶解度：
  可溶于氯仿（少许）、DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xi
• 危险类别码：
  R36/37/38
• 海关编码：
  2931900090
• 安全说明：
  S26,S36/37/39

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3-(Diethylphosphono)propanoic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3-(Diethylphosphono)propanoic acid
CAS number: 3095-96-3

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C7H15O5P
Molecular weight: 210.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-(二乙基膦)丙酸 在 吡啶 、 草酰氯 、 sodium hydride 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 5.0h， 生成 3-(Diethoxyphosphoryl)methylcoumarin
  参考文献：
  名称：

  A Convenient Horner-Emmons Approach to the Synthesis of Substituted Ethyl 1,3-Butadiene-2-carboxylates, and Related Compounds

  摘要：

  烯丙基膦酸酯3与醛的霍纳-埃蒙斯反应以令人满意的收率得到取代的1,3-丁二烯-2-羧酸酯12。通过对反应物进行适当的改性，可以以高几何选择性制备多种3-烯基-2(5H)呋喃酮13和3-烯基香豆素14。

  DOI：

  10.1055/s-1989-27301
• 作为产物：
  描述：

  3-膦酰丙酸三乙脂 在 盐酸 、 水 作用下， 以 丙酮 为溶剂， 生成 3-(二乙基膦)丙酸
  参考文献：
  名称：

  用于纳米医学的仿生肽修饰磷灰石纳米粒子的一锅法合成

  摘要：

  混合有机-无机仿生磷灰石纳米粒子（NP）对于生物医学应用，尤其是纳米医学领域具有吸引力。不幸的是，它们在纳米医学中的应用受到其宽粒度分布和由于其多步骤合成过程而导致的载药量不受控制的限制。此外，很少有人尝试将生物活性肽暴露在磷灰石纳米颗粒上。在这项工作中，报道了一种原始的一锅法合成明确的生物活性杂化纳米粒子，该纳米粒子由受生物活性肽有机冠包围的仿生磷灰石矿物核心组成。制备双稳定生物活性剂——磷酸化聚乙二醇-肽缀合物，并在磷灰石沉淀过程中直接使用 i) 在磷灰石沉淀过程中形成有机冠，通过胶体稳定作用驱动所得杂化纳米粒子的大小和形状，以及 ii) 暴露肽在纳米颗粒外围添加部分（RGD 或 YIGSR 序列），以赋予额外的表面特性以增强其与细胞的相互作用。在这里，这种方法的成功得到了证明，功能化的纳米颗粒通过傅里叶变换红外、拉曼、X射线衍射、固态和液态核磁共振、透射电子显微镜和动态光散射以及它们

  DOI：

  10.1002/smll.202306358

文献信息

• [EN] NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS<br/>[FR] NOUVELLES AMIDINES DE THIOPHENE, COMPOSITIONS DE CES AMIDINES ET PROCEDE POUR TRAITER DES MALADIES ET DES ETATS MEDIES PAR LE COMPLEMENT
  申请人：DIMENSIONAL PHARM INC

  公开号：WO2003099805A1

  公开（公告）日：2003-12-04

  Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.

  揭示了一种治疗急性或慢性疾病症状的方法，该方法通过补体级联的经典途径介导，包括向需要此类治疗的哺乳动物施用化合物I的治疗有效量或其溶剂化合物、水合物或药用可接受盐；其中规范中定义了R1、R2、R3、R4和R7，Z为SO或SO2，Ar为本规范中定义的芳香族或杂环芳基。
• Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20040009995A1

  公开（公告）日：2004-01-15

  Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I 1 or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R 1 , R 2 , R 3 , R 4 and R 7 are defined in the specification, Z is SO or SO 2 , and Ar is an aromatic or heteroaromatic group as defined herein.

  揭示了一种治疗急性或慢性疾病症状的方法，该方法通过补体级联的经典途径介导，包括向需要此类治疗的哺乳动物施用公式I的化合物的治疗有效量或其溶剂化合物、水合物或药用可接受盐；其中在规范中定义了R1、R2、R3、R4和R7，Z为SO或SO2，Ar为本文中定义的芳香族或杂环芳基。
• GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS WITH IMPROVED SOLUBILITY
  申请人：Rafai Far Adel

  公开号：US20120149632A1

  公开（公告）日：2012-06-14

  The invention relates to derivatives of glycopeptide and lipoglycopeptide antibiotics possessing an altered ionization state with respect to the parent glycopeptide or lipoglycopeptide antibiotic, and having the ability to be regenerated as the parent glycopeptide or lipoglycopeptide antibiotic under physiological conditions. These compounds are useful as antibiotics for the prevention and/or the treatment of bacterial infections.

  这项发明涉及具有与母体糖肽或脂质糖肽抗生素相比具有改变的电离状态的糖肽和脂质糖肽抗生素衍生物，并且具有在生理条件下能够再生为母体糖肽或脂质糖肽抗生素的能力。这些化合物可用作预防和/或治疗细菌感染的抗生素。
• Synthesis of Photodegradable Surface Modifiers Based on Phosphonic Acid for Introducing Functional Groups onto a Substrate and Application for Patterned Deposition of Gold Nano-Particulate Ink
  作者：Takuma Igari、Kana Imamura、Kenta Yasumura、Tomoki Iwasa、Kazuki Sakakibara、Kazuo Yamaguchi

  DOI：10.1246/bcsj.20180391

  日期：2019.5.15

  Techniques for selective deposition of conductive inks, in particular metal nano-particulate inks, by using self-assembling monolayers (SAMs) mostly involve control of wettability with highly hydro...

  通过使用自组装单分子层 (SAM) 选择性沉积导电油墨，特别是金属纳米颗粒油墨的技术主要涉及用高水...
• 化合物、表面処理剤、及び表面処理方法
  申请人：学校法人神奈川大学

  公开号：JP2016210778A

  公开（公告）日：2016-12-15

  【課題】表面処理剤としての使用に適した安定性の高い新規な化合物、該化合物を含有する表面処理剤及び表面処理方法の提供。【解決手段】下記式（Ｉ）で表される化合物。（Ｒ１〜Ｒ４はそれぞれ独立にＨ、アルキル基、又は置換基としてパーフルオロアルキル基を有してもよいアルコキシ基；Ｒ５はＨ又は置換基としてハロゲン原子を有してもよいＣ１〜６アルキル基；Ｘは−ＯＣＯＮＨ−、−ＯＣＯＳ−、−ＯＣＯＯ−、−ＮＨ−、−Ｓ−、−Ｏ−、−ＯＣＯ−のいずれかで表される基；Ｒ６はＸが−ＯＣＯ−以外である場合アルキレン基であり、Ｘが−ＯＣＯ−である場合単結合又はアルキレン基である。）【選択図】図１

  提供一种适用于作为表面处理剂的稳定性高的新化合物，包括该化合物的表面处理剂和表面处理方法。所述化合物由下式（I）表示。（R1-R4分别独立地为H、烷基或可取代的全氟烷基的醚基；R5为H或可取代的含卤素原子的C1-6烷基；X表示基团，可为-OCONH-、-OCOS-、-OCOO-、-NH-、-S-、-O-、-OCO-中的任意一种；R6为亚烷基基团，当X不为-OCONH-时，或者为单键或亚烷基基团，当X为-OCONH-时。）【选定图】图1