[1,1':4',1''-Terphenyl]-3-carboxamide, 6-chloro-N-pyrazinyl- | 877609-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1,1':4',1''-Terphenyl]-3-carboxamide, 6-chloro-N-pyrazinyl-
• 英文别名: 4-chloro-3-(4-phenylphenyl)-N-pyrazin-2-ylbenzamide
• CAS: 877609-28-4
• 化学式: C₂₃H₁₆ClN₃O
• 分子量: 385.8
• InChiKey: UIMRUKFBTILVAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compositions and their use as anti-tumor agents
  申请人：Kanne David

  公开号：US20090018145A1

  公开（公告）日：2009-01-15

  The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreating carcinomas) and mesotheliomas.

  本发明提供了新型化合物及其药物组合物，以及使用这些化合物和药物组合物治疗肿瘤的方法。这些化合物可能用于治疗的具体肿瘤类型包括但不限于肉瘤、黑色素瘤、神经母细胞瘤、癌瘤（包括但不限于肺癌、肾细胞癌、卵巢癌、肝癌、膀胱癌和胰腺癌）以及间皮瘤。
• Topoisomerase inhibitors
  申请人：Murphy A. Martin

  公开号：US20070004701A1

  公开（公告）日：2007-01-04

  The present invention provides compounds that are effective against inhibiting topoisomerase (i.e., topoisomerase I and/or topoisomerase II). These compounds are used for treating cell-proliferative disorders. In some instances, these compounds have anticancer activity, e.g., against multi-drug resistant cancers.

  本发明提供了一些化合物，这些化合物有效地抑制拓扑异构酶（即拓扑异构酶I和/或拓扑异构酶II）。这些化合物被用于治疗细胞增殖性疾病。在某些情况下，这些化合物具有抗癌活性，例如对多药耐药癌症。
• Compositions and Their Use as Anti-Tumor Agents
  申请人：Kanne David

  公开号：US20110178087A1

  公开（公告）日：2011-07-21

  The present invention provides novel compounds and pharmaceutical compositions thereof, as well as methods for using the compounds and pharmaceutical compositions for treating tumors. Examples of specific tumor types that the compounds may be used to treat include, but are not limited to sarcomas, melanomas, neuroblastomas, carcinomas (including but not limited to lung, renal cell, ovarian, liver, bladder, and pancreatic carcinomas), and mesotheliomas.

  本发明提供了新型化合物及其制药组合物，以及使用这些化合物和制药组合物治疗肿瘤的方法。这些化合物可用于治疗特定类型的肿瘤，包括但不限于肉瘤、黑色素瘤、神经母细胞瘤、癌瘤（包括但不限于肺癌、肾细胞癌、卵巢癌、肝癌、膀胱癌和胰腺癌）以及间皮瘤。
• ARYLCARBOXAMIDES AND THEIR USE AS ANTI-TUMOR AGENTS
  申请人：Compass Pharmaceuticals LLC

  公开号：EP1802606B1

  公开（公告）日：2011-03-16
• US7683097B2
  申请人：——

  公开号：US7683097B2

  公开（公告）日：2010-03-23