3-(二甲氨基)-4-苯基丁烷-2-酮 | 61039-20-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(二甲氨基)-4-苯基丁烷-2-酮
• 英文名称: 3-dimethylamino-4-phenylbutan-2-one
• 英文别名: 3-dimethylamino-4-phenyl-butan-2-one；3-Dimethylamino-4-phenyl-butan-2-on；2-Butanone, 3-(dimethylamino)-4-phenyl-；3-(dimethylamino)-4-phenylbutan-2-one
• CAS: 61039-20-1
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: SDTLLOXEQAFNRQ-UHFFFAOYSA-N

物化性质

• 沸点：
  105-106 °C(Press: 3 Torr)
• 密度：
  0.990±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(二甲氨基)-4-苯基丁烷-2-酮 、 乙基溴化镁 以65%的产率得到
  参考文献：
  名称：

  VOSKANYAN, V. S.;KOCHARYAN, S. T.;BABAYAN, A. T., ARM. XIM. ZH., 1984, 37, N 9, 596-599

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydroxide 作用下， 生成 3-(二甲氨基)-4-苯基丁烷-2-酮
  参考文献：
  名称：

  Stevens et al., Journal of the Chemical Society, 1930, p. 2119,2123

  摘要：

  DOI：

文献信息

• AKT PROTEIN KINASE INHIBITORS
  申请人：Array BioPharma, Inc.

  公开号：US20140148436A1

  公开（公告）日：2014-05-29

  The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

  本发明提供了化合物，包括已分离的对映体、非对映异构体、溶剂化物和药学上可接受的盐，其化学式为A-L-CR，其中CR是一个环状核心基团，L是一个连接基团，A如本文所定义。本发明还提供了使用该化合物作为AKT蛋白激酶抑制剂和用于治疗高增殖性疾病，如癌症的方法。
• [EN] LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE<br/>[FR] CONJUGUÉS PEPTIDIQUES DOUBLE GIP/GLP-1 À ACTION PROLONGÉE ET PROCÉDÉS D'UTILISATION
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2022257979A1

  公开（公告）日：2022-12-15

  Provided herein are peptides and peptide conjugates comprising a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. The peptides may be used for blood glucose management and treating conditions such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH).

  本文提供了含有双重葡萄糖依赖性胰岛素促泌肽（GIP）和GLP-1受体激动剂的肽和肽共轭物。这些肽可以用于血糖管理和治疗糖尿病、肥胖症、非酒精性脂肪肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）等疾病。
• Halomethyl-1,3,5-triazines containing a photoinitiator moiety
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0361682A1

  公开（公告）日：1990-04-04

  This invention relates to photosensitive compounds, more particularly, derivatives of halomethyl-1,3,5-triazines. Halomethyl-1,3,5-triazines are known to be initiators for a number of photochemical reactions. Mixed initiators have been disclosed for use with polymerizable monomers. It would be desirable to combine a halomethyl-1,3,5-triazine with a second photoinitiator in the same molecule to provide an improved photoinitiator. This invention provides radiation-sensitive organo-halogen compounds having a photo-labile halomethyl-1,3,5-triazine moiety and at least one photoinitator moiety within one molecule. The compounds of this invention are good photoinitiators, and compositions containing them can be used in printing, duplicating, copying, and other imaging systems. The compounds of this invention eliminate the need for a combination of photoinitiators in a photocurable or photopolymerizable composition.

  本发明涉及光敏化合物，特别是卤代甲基-1,3,5-三嗪的衍生物。 卤代甲基-1,3,5-三嗪是许多光化学反应的已知引发剂。混合引发剂已被公开用于可聚合单体。将卤代甲基-1,3,5-三嗪与第二种光引发剂结合在同一分子中，以提供一种改良的光引发剂是可取的。 本发明提供了对辐射敏感的有机卤素化合物，该化合物在一个分子中具有一个光致弱的卤代甲基-1,3,5-三嗪分子和至少一个光引发剂分子。本发明的化合物是良好的光引发剂，含有它们的组合物可用于印刷、复制、复印和其他成像系统。本发明化合物无需在光固化或光聚合组合物中结合使用光引发剂。
• Polymers containing halomethyl-1,3,5-triazine moieties
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0441524A2

  公开（公告）日：1991-08-14

  The present invention relates to photosensitive compounds, more particularly polymers containing halomethyl-1,3,5-triazine moieties and to radiation-sensitive compositions and elements utilizing these polymers. Migration typically occurs in photopolymerizable compositions containing low molecular weight monomers and plasticizers, which tend to diffuse between layers, carrying along other ingredients such as the photoinitiator. This invention provides radiation-sensitive organo-halogen compounds that have a photo-labile halomethyl-1,3,5-triazine moiety and a polymeric moiety within the same molecule. The compounds of this invention are comprised of a polymeric moiety having attached or incorporated within its structure at least one 1,3,5-triazine nucleus, said triazine nucleus having at least one halomethyl substituent attached to a carbon atom of the triazine nucleus. These compounds are capable of being stimulated by actinic radiation at wavelengths of from about 250 to about 900 nanometers to generate free radicals and/or acids. The compounds of this invention are useful as photoinitiators in free radical polymerization reactions, oxidation-reduction reactions, or reactions sensitive to acid, and they also exhibit the capability to crosslink upon exposure to light. The polymers of this invention are less susceptible to migration on account of the anchoring or ballasting of the halomethyl-1,3,5-triazine.

  本发明涉及光敏化合物，特别是含有卤代甲基-1,3,5-三嗪分子的聚合物，以及利用这些聚合物的辐射敏感组合物和元件。迁移通常发生在含有低分子量单体和增塑剂的可光聚合组合物中，这些单体和增塑剂容易在层间扩散，并携带光引发剂等其他成分。本发明提供了对辐射敏感的有机卤素化合物，这些化合物在同一分子中具有光敏卤甲基-1,3,5-三嗪分子和聚合分子。本发明的化合物由聚合分子组成，聚合分子的结构中连接或包含至少一个 1,3,5-三嗪核，所述三嗪核的碳原子上连接有至少一个卤代甲基。这些化合物能够在波长为 250 纳米到 900 纳米的光辐射刺激下生成自由基和/或酸。本发明的化合物在自由基聚合反应、氧化还原反应或对酸敏感的反应中可用作光引发剂，它们还能在光照下交联。由于卤甲基-1,3,5-三嗪的锚定或压载作用，本发明的聚合物不易迁移。
• Fourneau; Barrelet, Bulletin de la Societe Chimique de France, 1930, vol. <4> 47, p. 72,77
  作者：Fourneau、Barrelet

  DOI：——

  日期：——