Benzenemethanesulfonamide, N-3-butynyl-2-(trifluoromethyl)- | 828283-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzenemethanesulfonamide, N-3-butynyl-2-(trifluoromethyl)-
• 英文别名: N-but-3-ynyl-1-[2-(trifluoromethyl)phenyl]methanesulfonamide
• CAS: 828283-27-8
• 化学式: C₁₂H₁₂F₃NO₂S
• 分子量: 291.29
• InChiKey: UYPFHTYEUQXMQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors
  申请人：Michalak S. Ronald

  公开号：US20060041005A1

  公开（公告）日：2006-02-23

  The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.

  本发明提供了制备化合物的方法，其化学式为1：包括以下步骤：将化合物的化学式为2和3反应，得到化合物的化学式为4：其中R1、R2、R3、R4和R5的定义如本文所述。化合物的化学式为4然后转化为化合物的化学式为1。本发明还包括化学式为3和4的化合物以及制备化学式为3和4的方法。
• Advanced route for the synthesis of cPLA2 inhibitors
  申请人：Wu Yanzhong

  公开号：US20050020858A1

  公开（公告）日：2005-01-27

  A process for making a compound of formula (I) in which process the compound HC≡C—(CH 2 ) n —NH 2 is reacted with the compound R 1 —SO 2 Cl to produce an intermediate compound, which intermediate compound is then reacted with the compound of formula to produce the compound of formula (I), and compounds produced by the process of this invention. The terms R 1 , R 2 , R 3 , R 4 and n have the definitions set forth in the specification.

  一种制备式(I)化合物的方法，其中化合物HC≡C—(CH2)n—NH2与化合物R1—SO2Cl反应，生成中间体化合物，然后将该中间体化合物与式的化合物反应，从而产生式(I)的化合物，以及该发明的方法产生的化合物。术语R1、R2、R3、R4和n的定义在规范中说明。
• [EN] PROCESS FOR THE SYNTHESIS C-2, C-3 SUBSTITUTED N-ALKYLATED INDOLES USEFUL AS CPLA2 INHIBITORS<br/>[FR] PROCEDE DE SYNTHESE D'INDOLES N-ALKYLES SUBSTITUES EN C-2, C-3 UTILES COMME INHIBITEURS DE LA CPLA2
  申请人：WYETH CORP

  公开号：WO2006023611A1

  公开（公告）日：2006-03-02

  The present invention provides method for making a compound of formula (1) comprising the steps of reacting compounds of formulas (2) and (3) to produce a compound of formula (4) wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula (4) is then converted to the compound of formula (1). The invention further comprises compounds of formula (3) and (4) and methods for making compounds of formulae (3) and (4).

  本发明提供了一种制备化合物（1）的方法，包括以下步骤：反应化合物（2）和（3）的化合物，以产生化合物（4），其中R1、R2、R3、R4和R5如本文所述。然后将化合物（4）转化为化合物（1）。本发明还涉及化合物（3）和（4）以及制备化合物（3）和（4）的方法。
• Process for the Synthesis of C-2, C-3 Substituted N-Alkylated Indoles Useful as cPLA2 Inhibitors
  申请人：Michalak Ronald S.

  公开号：US20090306428A1

  公开（公告）日：2009-12-10

  The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R 1 , R 2 , R 3 , R 4 and R 5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.

  本发明提供了一种制备公式1化合物的方法，包括以下步骤：反应公式2和3的化合物，以产生公式4的化合物，其中R1、R2、R3、R4和R5的定义如本文所述。然后将公式4的化合物转化为公式1的化合物。本发明还包括公式3和4的化合物以及制备公式3和4的方法。
• Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As CPLA2 Inhibitors
  申请人：Michalak Ronald S.

  公开号：US20110054189A1

  公开（公告）日：2011-03-03

  The present invention provides a compound of formula 1: wherein R 1 is CF 3 , R 2 is H, R 3 is H, and R 4 is H.

  本发明提供了一种化合物，其化学式为1：其中R1为CF3，R2为H，R3为H，R4为H。