2-(4-Nitrophenoxycarbonyl)amino-5-phenylthiazole | 497177-64-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-Nitrophenoxycarbonyl)amino-5-phenylthiazole
• 英文别名: (4-nitrophenyl) N-(5-phenyl-1,3-thiazol-2-yl)carbamate
• CAS: 497177-64-7
• 化学式: C16H11N3O4S
• 分子量: 341.3
• InChiKey: IDUZYDNEVJIGLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(4-Nitrophenoxycarbonyl)amino-5-phenylthiazole 、 N-(5-phenylthiazol-2-yl)-N'-[4-(pyrrolidinocarbonylmethyl)piperazin-1-yl]-urea 以117 mg (0.59 mmol) of 1-(pyrrolidinocarbonylmethyl)piperazine was obtained 12 as an amorphous white powder after lyophilization的产率得到1-(吡咯烷基羰基甲基)哌嗪
  参考文献：
  名称：

  Tyrosine kinase inhibitors

  摘要：

  本发明涉及抑制、调节和/或调节酪氨酸激酶信号转导的化合物、含有这些化合物的组合物以及使用它们治疗哺乳动物中的酪氨酸激酶依赖性疾病和病况的方法，例如血管生成、癌症、肿瘤生长、动脉粥样硬化、年龄相关性黄斑变性、糖尿病视网膜病变、炎症性疾病等。

  公开号：

  US07265134B2

文献信息

• US7265134B2
  申请人：——

  公开号：US7265134B2

  公开（公告）日：2007-09-04
• [EN] TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINES KINASES
  申请人：MERCK & CO INC

  公开号：WO2003015717A2

  公开（公告）日：2003-02-27

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
• [EN] TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASE
  申请人：MERCK & CO INC

  公开号：WO2003015778A1

  公开（公告）日：2003-02-27

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
• Tyrosine kinase inhibitors
  申请人：——

  公开号：US20040192926A1

  公开（公告）日：2004-09-30

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

  本发明涉及抑制、调节和/或调节酪氨酸激酶信号转导的化合物，含有这些化合物的组合物，以及使用它们治疗哺乳动物中的酪氨酸激酶依赖性疾病和病状的方法，如血管生成、癌症、肿瘤生长、动脉硬化、年龄相关性黄斑变性、糖尿病性视网膜病变、炎症性疾病等。