Benzamide, 4-chloro-N-(4-mercaptophenyl)- | 178671-47-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzamide, 4-chloro-N-(4-mercaptophenyl)-
• 英文别名: 4-chloro-N-(4-sulfanylphenyl)benzamide
• CAS: 178671-47-1
• 化学式: C₁₃H₁₀ClNOS
• 分子量: 263.74
• InChiKey: QZKCSEJIUOKBRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• 2,2-DICHLORALKANCARBONSÄUREN, VERFAHREN ZU IHRER HERSTELLUNG DIESE ENTHALTENDE ARZNEIMITTEL, UND IHRE VERWENDUNG ZUR BEHANDLUNG DER INSULINRESISTENZ
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0790824A1

  公开（公告）日：1997-08-27
• US5968982A
  申请人：——

  公开号：US5968982A

  公开（公告）日：1999-10-19
• [DE] 2,2-DICHLORALKANCARBONSÄUREN, VERFAHREN ZU IHRER HERSTELLUNG DIESE ENTHALTENDE ARZNEIMITTEL, UND IHRE VERWENDUNG ZUR BEHANDLUNG DER INSULINRESISTENZ<br/>[EN] 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE<br/>[FR] ACIDES 2,2-DICHLOROALCANECARBOXYLIQUES, LEUR PROCEDE DE PREPARATION, MEDICAMENTS LES CONTENANT, ET LEUR UTILISATION DANS LE TRAITEMENT DE LA RESISTANCE INSULINIQUE
  申请人：——

  公开号：WO1996015784A2

  公开（公告）日：1996-05-30

  [EN] A medicament for the treatment of diabetes mellitus contains as active substance a compound having the formula (I), in which A, B, A' and W have the meanings given in the description. Also disclosed are new compounds having the formula (I) and a process for preparing the same.
  [FR] L'invention concerne un médicament de traitement du diabète sucré qui contient comme principe actif un composé ayant la formule (I), dans laquelle A, B, A' et W ont la notation donnée dans les revendications, de nouveaux composés ayant la formule (I) et leur procédé de préparation.
  [DE] Arzneimittel zur Behandlung des Diabetes mellitus, die als Wirkstoff eine Verbindung der Formel (I) enthalten in der A, B, A' und W die in den Ansprüchen angegebene Bedeutung haben, neue Verbindungen der Formel (I) sowie Verfahren zu ihrer Herstellung.
• [EN] 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIC ACID DERIVATES<br/>[FR] DERIVES D'ACIDE 3-ARYLSULFONYL-2-HYDROXY-2-METHYLPROPANOIQUE
  申请人：PHARMACIA & UPJOHN SPA

  公开号：WO2002006215A1

  公开（公告）日：2002-01-24

  A compound which is an arylsulfonyl propanoic acid derivative of formula (I) : CH2R1 XC(O)-C(OH)-SO2-C6H4-N(R2)COA (I) wherein X is HO-NH- or HO- , R1 is selected from -O-Ph, -S-Ph, -S-Het, -Hyd or -CH2-Hyd, wherein Ph is a phenyl group; Het is a heterocyclic ring and Hyd is a substituted hydantoin-3-yl ring; A is a phenyl group or Het as defined above, or a condensed phenyl ring; and R2 is either hydrogen or methyl; or R2 represents a methylene (-CH2-) bridge connecting the N atom to the ortho position of said A to form a 5-membered lactam; or a salt or an oral prodrug thereof.The compounds are inhibitors of matrix metallo-proteinases (MMPs) and are therefore useful in the prevention, control and treatment of diseases in which MMPs are involved.