1-[(E)-1,2-bis(4-methoxyphenyl)ethenyl]sulfonyl-4-methylbenzene | 1563173-89-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-[(E)-1,2-bis(4-methoxyphenyl)ethenyl]sulfonyl-4-methylbenzene
• CAS: 1563173-89-6
• 化学式: C₂₃H₂₂O₄S
• 分子量: 394.491
• InChiKey: KIIUARLEPDBCDY-XQNSMLJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[(E)-1,2-bis(4-methoxyphenyl)ethenyl]sulfonyl-4-methylbenzene 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以66%的产率得到林可霉素 2,7-二乙酸酯
  参考文献：
  名称：

  One-pot synthesis of sulfonyl (E)-stilbenes by nitrobenzene-mediated dimerizative desulfonation of benzylic sulfones

  摘要：

  A facile one-pot synthetic route for preparing sulfonyl (E)-stilbenes 4 is developed. The efficient route is realized by a nitrobenzene (PhNO2)-mediated dimerizative desulfonation of benzylic sulfones 3 in the presence of sodium hydride (NaH) in good yields. Some synthetic investigations of sulfonyl stilbenes 4 are also examined. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.045
• 作为产物：
  描述：

  1-methoxy-4-(tosylmethyl)benzene 在 sodium hydride 、 硝基苯 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 3.0h， 以72%的产率得到1-[(E)-1,2-bis(4-methoxyphenyl)ethenyl]sulfonyl-4-methylbenzene
  参考文献：
  名称：

  One-pot synthesis of sulfonyl (E)-stilbenes by nitrobenzene-mediated dimerizative desulfonation of benzylic sulfones

  摘要：

  A facile one-pot synthetic route for preparing sulfonyl (E)-stilbenes 4 is developed. The efficient route is realized by a nitrobenzene (PhNO2)-mediated dimerizative desulfonation of benzylic sulfones 3 in the presence of sodium hydride (NaH) in good yields. Some synthetic investigations of sulfonyl stilbenes 4 are also examined. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.045

文献信息

• One-pot synthesis of sulfonyl (E)-stilbenes by nitrobenzene-mediated dimerizative desulfonation of benzylic sulfones
  作者：Meng-Yang Chang、Yi-Chia Chen、Shin-Ying Lin、Chieh-Kai Chan

  DOI：10.1016/j.tet.2014.01.045

  日期：2014.3

  A facile one-pot synthetic route for preparing sulfonyl (E)-stilbenes 4 is developed. The efficient route is realized by a nitrobenzene (PhNO2)-mediated dimerizative desulfonation of benzylic sulfones 3 in the presence of sodium hydride (NaH) in good yields. Some synthetic investigations of sulfonyl stilbenes 4 are also examined. (C) 2014 Elsevier Ltd. All rights reserved.