2-(4-chloro-phenyl)-2-methoxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide | 374726-54-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-chloro-phenyl)-2-methoxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide
• 英文别名: 2-(4-chlorophenyl)-2-methoxy-N-[2-(3-methoxy-4-prop-2-ynoxyphenyl)ethyl]acetamide
• CAS: 374726-54-2
• 化学式: C₂₁H₂₂ClNO₄
• 分子量: 387.863
• InChiKey: OUKGFOGAFSLWLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(4-chlorophenyl)-2-hydroxy-N-[2-(3-methoxy-4-(prop-2-ynyloxy)phenyl)ethyl]acetamide 、 碘甲烷 在 sodium hydride 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 3.5h， 生成 2-(4-chloro-phenyl)-2-methoxy-N-[2-(3-methoxy-4-prop-2-ynyloxy-phenyl)-ethyl]-acetamide
  参考文献：
  名称：

  Phenyl-propargylether derivatives

  摘要：

  该发明涉及一般式I的苯基-丙炔醚衍生物，包括其光学异构体和这些异构体的混合物，其中 R1为氢、烷基、环烷基或可选择取代的芳基， R2和R3分别独立为氢或烷基， R4为烷基、烯基或炔基， R5、R6、R7和R8分别独立为氢或烷基， R9为氢、可选择取代的烷基、可选择取代的烯基或可选择取代的炔基， R10为可选择取代的芳基或可选择取代的杂环芳基，以及 Z为卤素、可选择取代的芳氧基、可选择取代的烷氧基、可选择取代的烯氧基、可选择取代的炔氧基、可选择取代的芳硫基、可选择取代的烷硫基、可选择取代的烯硫基、可选择取代的炔硫基、可选择取代的烷亚砜基、可选择取代的烯亚砜基、可选择取代的炔亚砜基、可选择取代的烷砜基、可选择取代的烯砜基或可选择取代的炔砜基。这些化合物具有有用的植物保护性能，并可有利地用于农业实践中，用于控制或预防植物受植物病原微生物，特别是真菌的侵害。

  公开号：

  US06683211B1

文献信息

• Novel n-p-propargyloxyphenethyl-thioacetic acid amides
  申请人：——

  公开号：US20040127739A1

  公开（公告）日：2004-07-01

  The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R 1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R 2 and R 3 are each independently hydrogen or alkyl, R 4 is alkyl, alkenyl or alkynyl, R 5 , R 6 , R 7 and R 8 are each independently hydrogen or alkyl, R 9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R 10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is hydroxy, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenysulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl, optionally substituted alkynylsulfonyl or a group —O—CO—R 11 , —O—CO—O—R 11 or —O—CO—CO—O—R 11 wherein R 11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. 1

  本发明涉及一般式（I）的N-丙炔氧基-苯乙硫酸酰胺衍生物，包括其光学异构体和混合物，其中R1是氢、烷基、环烷基或可选取代芳基，R2和R3各自独立地是氢或烷基，R4是烷基、烯基或炔基，R5、R6、R7和R8各自独立地是氢或烷基，R9是氢、可选取代烷基、可选取代烯基或可选取代炔基，R10是可选取代芳基或可选取代杂环芳基，Z是羟基、可选取代芳氧基、可选取代烷氧基、可选取代炔基氧基、可选取代芳硫基、可选取代烷硫基、可选取代炔基硫基、可选取代烷基亚砜基、可选取代烯基亚砜基、可选取代炔基亚砜基、可选取代烷基磺酰基、可选取代烯基磺酰基、可选取代炔基磺酰基或基团—O—CO—R11，—O—CO—O—R11或—O—CO—CO—O—R11，其中R11是氢、可选取代烷基、可选取代环烷基、可选取代芳基或可选取代杂环芳基。这些化合物具有有用的植物保护特性，并可优势地用于农业实践中控制或预防植物受植物病原微生物（尤其是真菌）侵害。
• Novel phenyl-propargylether derivatives
  申请人：Zeller Martin

  公开号：US20050026785A1

  公开（公告）日：2005-02-03

  The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such osimers, wherein R 1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R 2 and R 3 are each independently hydrogen or alkyl, R 4 is alkyl, alkenal or alkynyl, R 5 , R 6 , R 7 , and R 8 are each independently hydrogen or alkal, R 9 is hydrogen, optionally substituted alkyl, optionnaly substituted alkenyl or optionally substituted alkynyl, R 10 is optionally substituted aryl or optionaly substituted heteroaryl, and Z is optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy or optionally substituted alkynyloxy. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

  本发明涉及一般式I的苯基丙炔醚衍生物，包括其光学异构体和这些异构体的混合物，其中R1为氢、烷基、环烷基或可选取代芳基，R2和R3各自独立地为氢或烷基，R4为烷基、烯醛或炔基，R5、R6、R7和R8各自独立地为氢或烷基，R9为氢、可选取代烷基、可选取代烯基或可选取代炔基，R10为可选取代芳基或可选取代杂环芳基，Z为可选取代芳氧基、可选取代烷氧基、可选取代烯氧基或可选取代炔氧基。这些化合物具有有用的植物保护性能，可以优势地用于农业实践中控制或预防植物受到植物病原微生物，特别是真菌的侵害。
• N-p-propargyloxyphenethyl-thioacetic acid amides
  申请人：Syngenta Crop Protection, Inc.

  公开号：US07105545B2

  公开（公告）日：2006-09-12

  The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7 and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is hydroxy, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenysulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl, optionally substituted alkynylsulfonyl or a group —O—CO—R11, —O—CO—O—R11 or —O—CO—CO—O—R11 wherein R11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi

  本发明涉及一般式（I）的N-丙炔氧基苯乙基硫代乙酸酰胺衍生物，包括其光学异构体和混合物，其中R1为氢、烷基、环烷基或可选取代芳基，R2和R3各自独立地为氢或烷基，R4为烷基、烯基或炔基，R5、R6、R7和R8各自独立地为氢或烷基，R9为氢、可选取代烷基、可选取代烯基或可选取代炔基，R10为可选取代芳基或可选取代杂环芳基，Z为羟基、可选取代芳氧基、可选取代烷氧基、可选取代炔氧基、可选取代芳硫基、可选取代烷硫基、可选取代炔硫基、可选取代烷基亚砜基、可选取代烯基亚砜基、可选取代炔基亚砜基、可选取代烷基磺酰基、可选取代烯基磺酰基、可选取代炔基磺酰基或基团-O-CO-R11，-O-CO-O-R11或-O-CO-CO-O-R11，其中R11为氢、可选取代烷基、可选取代环烷基、可选取代芳基或可选取代杂环芳基。这些化合物具有有用的植物保护性能，可以优势地用于农业实践中，用于控制或预防植物受植物病原微生物，特别是真菌的侵害。
• Pesticide composition comprising fosetyl-aluminium and an insecticide active substance
  申请人：Bayer CropScience AG

  公开号：EP2245937A1

  公开（公告）日：2010-11-03

  The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of treatment using the said composition. More precisely, the subject of the present invention is a pesticide composition based on fosetyl-Al, an insecticide active substance and optionally a further fungicide active substance.

  本发明涉及一种用于保护植物、农作物或种子免受植物病原真菌或有害昆虫危害的农药组合物，以及使用上述组合物的相应处理方法。更确切地说，本发明的主题是一种基于磷脂酰-Al、杀虫剂活性物质和可选的另一种杀真菌剂活性物质的杀虫剂组合物。
• Pesticde composition comprising fosetyl-aluminium and an insecticide active substance
  申请人：Bayer CropScience AG

  公开号：EP2250899A2

  公开（公告）日：2010-11-17

  The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of treatment using the said composition. More precisely, the subject of the present invention is a pesticide composition based on fosetyl-Al, an insecticide active substance and optionally a further fungicide active substance.

  本发明涉及一种用于保护植物、农作物或种子免受植物病原真菌或有害昆虫危害的农药组合物，以及使用上述组合物的相应处理方法。更确切地说，本发明的主题是一种基于磷脂酰-Al、杀虫剂活性物质和可选的另一种杀真菌剂活性物质的杀虫剂组合物。