2-Chloro-N-p-tolyl-thiobenzamide | 518068-00-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloro-N-p-tolyl-thiobenzamide
• 英文别名: Benzenecarbothioamide, 2-chloro-N-(4-methylphenyl)-；2-chloro-N-(4-methylphenyl)benzenecarbothioamide
• CAS: 518068-00-3
• 化学式: C₁₄H₁₂ClNS
• 分子量: 261.775
• InChiKey: CIJHINKBGLIFAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  44.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Chloro-N-p-tolyl-thiobenzamide 在 Oxone 作用下， 反应 0.33h， 以82%的产率得到2-氯-N-(4-甲基苯基)苯甲酰胺
  参考文献：
  名称：

  在无溶剂条件下使用 Oxone 将硫代羰基化合物转化为其氧代衍生物的一种方便且廉价的方法

  摘要：

  摘要 一系列硫代酰胺、硫脲和硫酯在固相条件下与 oxone 一起转化为相应的羰基化合物，产率良好至极好，而硫酮在这些条件下保持不变。

  DOI：

  10.1081/scc-120016359

文献信息

• A Convenient and Inexpensive Method for Conversion of Thiocarbonyl Compounds to Their Oxo Derivatives Using Oxone Under Solvent-Free Conditions
  作者：Iraj Mohammadpoor-Baltork、Majid M. Sadeghi、Karim Esmayilpour

  DOI：10.1081/scc-120016359

  日期：2003.1.4

  Abstract A series of thioamides, thioureas and thioesters are transformed to their corresponding carbonyl compounds in good to excellent yields with oxone under solid phase conditions, while thioketones remained unchanged under these conditions.

  摘要 一系列硫代酰胺、硫脲和硫酯在固相条件下与 oxone 一起转化为相应的羰基化合物，产率良好至极好，而硫酮在这些条件下保持不变。
• Bismuth(III) nitrate pentahydrate: a convenient and selective reagent for conversion of thiocarbonyls to their carbonyl compounds
  作者：Iraj Mohammadpoor-Baltork、Mohammad Mehdi Khodaei、Kobra Nikoofar

  DOI：10.1016/s0040-4039(02)02516-9

  日期：2003.1

  A variety of thioamides and thioureas are rapidly transformed to their oxo derivatives with Bi(NO3)3·5H2O in excellent yields. However, thiono esters and thioketones are converted to their corresponding carbonyl compounds in only poor yields. Bi(NO3)3·5H2O is relatively non-toxic, insensitive to air and inexpensive. These features coupled with the selective deprotection of thioamides and thioureas

  各种硫代酰胺和硫脲可通过Bi（NO 3）3 ·5H 2 O迅速转化为它们的oxo衍生物，收率很高。然而，硫代酸酯和硫代酮仅以低收率转化为它们相应的羰基化合物。Bi（NO 3）3 ·5H 2 O相对无毒，对空气不敏感且价格便宜。这些特征与在硫代酸酯和硫代酮的存在下硫代酰胺和硫脲的选择性脱保护相结合，使得该方法成为现有的脱硫羰基化合物脱保护途径的有吸引力的替代方法。
• A Facile and Convenient Method for Deprotection of Thiocarbonyls to Their Carbonyl Compounds Using Oxone Under Aprotic and Nonaqueous Conditions
  作者：I. Mohammadpoor-Baltork、M. M. Sadeghi、K. Esmayilpour

  DOI：10.1080/10426500307781

  日期：2003.1.1

  The reaction of oxone as an inexpensive, stable, and commercially available reagent with thiocarbonyl compounds in refluxing acetonitrile has been studied. Primary, secondary, and tertiary thioamides and thioureas are converted to their oxo analogues efficiently. Thiono esters also are transformed to their corresponding esters, while thioketones remained intact under these conditions.
• Mohammadpoor-Baltork, Iraj; Sadeghi, Majid M. M.; Esmayilpour, Karim, Journal of Chemical Research - Part S, 2003, # 6, p. 348 - 350
  作者：Mohammadpoor-Baltork, Iraj、Sadeghi, Majid M. M.、Esmayilpour, Karim

  DOI：——

  日期：——
• Tajbakhsh; Mohammadpoor-Baltork; Alimohammadi, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 10, p. 2638 - 2640
  作者：Tajbakhsh、Mohammadpoor-Baltork、Alimohammadi

  DOI：——

  日期：——