methyl (2R)-2-[(3R)-2-methyloctan-3-yl]oxy-2-phenylacetate | 144297-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (2R)-2-[(3R)-2-methyloctan-3-yl]oxy-2-phenylacetate
• CAS: 144297-12-1
• 化学式: C₁₈H₂₈O₃
• 分子量: 292.419
• InChiKey: MMFBOUSTXRTICI-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  重氮甲烷 、 Isopropylkupfer 、 trans-2-pentyl-5-phenyl-1,3-dioxolan-4-one 生成 methyl (2R)-2-[(3R)-2-methyloctan-3-yl]oxy-2-phenylacetate 、
  参考文献：
  名称：

  Nucleophilic substitution at the acetalic center of mandelate 1,3-dioxolan-4-ones using magnesio-copper reagents: Application to the synthesis of chiral secondary alcohols.

  摘要：

  Ethereal magnesio-copper reagents, in contrast to lithio-copper reagents, add stereoselectively to mandelic acid derived 1,3-dioxolan-4-ones to afford optically active secondary alcohols after removal of the chiral auxiliary.

  DOI：

  10.1016/s0040-4039(00)79132-5

文献信息

• Nucleophilic substitution at the acetalic center of mandelate 1,3-dioxolan-4-ones using magnesio-copper reagents: Application to the synthesis of chiral secondary alcohols.
  作者：Bertrand Heckmann、Charles Mioskowski、Jurong Yu、J.R. Falck

  DOI：10.1016/s0040-4039(00)79132-5

  日期：1992.9

  Ethereal magnesio-copper reagents, in contrast to lithio-copper reagents, add stereoselectively to mandelic acid derived 1,3-dioxolan-4-ones to afford optically active secondary alcohols after removal of the chiral auxiliary.